Eric C. Freeman
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View article: ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity
ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity Open
Summary Triple-negative breast cancer (TNBC), defined by the lack of estrogen, progesterone, and HER2 receptor expressions, is aggressive and lacks targeted treatment options. Adenosine deaminase acting on RNA 1 (ADAR1) has been shown to c…
View article: Neuron‐Inspired Biomolecular Memcapacitors Formed Using Droplet Interface Bilayer Networks
Neuron‐Inspired Biomolecular Memcapacitors Formed Using Droplet Interface Bilayer Networks Open
Brain‐inspired (or neuromorphic) computing circumvents costly bottlenecks in conventional Von Neumann architectures by collocating memory and processing. This is accomplished through dynamic material architectures, strengthening or weakeni…
View article: Measuring the Transmembrane Registration of Lipid Domains in Droplet Interface Bilayers through Tensiometry
Measuring the Transmembrane Registration of Lipid Domains in Droplet Interface Bilayers through Tensiometry Open
Diverse collections of lipids self-assemble into domains within biological membranes, and these domains are typically organized in both the transverse and lateral directions of the membrane. The ability of the membrane to link these domain…
View article: Enhancing membrane-based soft materials with magnetic reconfiguration events
Enhancing membrane-based soft materials with magnetic reconfiguration events Open
Adaptive and bioinspired droplet-based materials are built using the droplet interface bilayer (DIB) technique, assembling networks of lipid membranes through adhered microdroplets. The properties of these lipid membranes are linked to the…
View article: Characterizing the Structure and Interactions of Model Lipid Membranes Using Electrophysiology
Characterizing the Structure and Interactions of Model Lipid Membranes Using Electrophysiology Open
The cell membrane is a protective barrier whose configuration determines the exchange both between intracellular and extracellular regions and within the cell itself. Consequently, characterizing membrane properties and interactions is ess…
View article: A new approach for investigating the response of lipid membranes to electrocompression by coupling droplet mechanics and membrane biophysics
A new approach for investigating the response of lipid membranes to electrocompression by coupling droplet mechanics and membrane biophysics Open
A new method for quantifying lipid–lipid interactions within biomimetic membranes undergoing electrocompression is demonstrated by coupling droplet mechanics and membrane biophysics. The membrane properties are varied by altering the lipid…
View article: 3174 Tumor suppressors p53 and ARF control oncogenic potential of triple-negative breast cancer cells by regulating RNA editing enzyme ADAR1
3174 Tumor suppressors p53 and ARF control oncogenic potential of triple-negative breast cancer cells by regulating RNA editing enzyme ADAR1 Open
OBJECTIVES/SPECIFIC AIMS: Triple-negative breast cancer (TNBC) accounts for one-fifth of the breast cancer patient population. The heterogeneous nature of TNBC and lack of options for targeted therapy make its treatment a constant challeng…
View article: Supplementary material from "A new approach for investigating the response of lipid membranes to electrocompression by coupling droplet mechanics and membrane biophysics"
Supplementary material from "A new approach for investigating the response of lipid membranes to electrocompression by coupling droplet mechanics and membrane biophysics" Open
A new method for quantifying lipid–lipid interactions within biomimetic membranes undergoing electrocompression is demonstrated by coupling droplet mechanics and membrane biophysics. The membrane properties are varied by altering the lipid…
View article: Recent advances in adaptive and active materials 2017
Recent advances in adaptive and active materials 2017 Open
Author(s): Karami, Amin; Anton, Steve; Nouh, Mostafa; Freeman, Eric; Tummala, Yash; Jovanova, Jovana
View article: Reconfiguring droplet interface bilayer networks through sacrificial membranes
Reconfiguring droplet interface bilayer networks through sacrificial membranes Open
The droplet interface bilayer platform allows for the fabrication of stimuli-responsive microfluidic materials, using phospholipids as an organic surfactant in water-in-oil mixtures. In this approach, lipid-coated droplets are adhered toge…
View article: Encapsulating Networks of Droplet Interface Bilayers in a Thermoreversible Organogel
Encapsulating Networks of Droplet Interface Bilayers in a Thermoreversible Organogel Open
The development of membrane-based materials that exhibit the range and robustness of autonomic functions found in biological systems remains elusive. Droplet interface bilayers (DIBs) have been proposed as building blocks for such material…