Explanipedia

Practice Patterns Regarding Quality Assurance Measures in Gynecologic Cytology: Survey Results of Laboratories Participating in the 2022 College of American Pathologists PAP Education Program Open

Abha Goyal, Diane D. Davey, Rhona J. Souers, Janie Roberson, Michael Henry , et al. · 2025

Context.— Though numerous quality assurance (QA) measures are in place for the practice of gynecologic cytopathology, many of them are not clearly defined and may be variably used by laboratories worldwide. Objective.— To assess current pr…

Gender Inclusion in the Cytopathology Laboratory: Review of Current Practice and Call to Action Open

Suzanne Crumley, Tatjana Antic, Donna K. Russell, Kaitlin E. Sundling, Eric C. Huang , et al. · 2025

Context.— Ensuring equitable laboratory patient care within diverse populations is a priority. The cytopathology laboratory has an important role in providing gender-inclusive care, particularly with regard to screening and prevention of h…

Risk of malignancy associated with indeterminate categories in the Milan System for reporting pediatric salivary gland cytopathology: a multi-institutional study Open

Huiying Wang, Vivian Weiß, Melissa Straub Hogan, Oscar Lin, Sara E. Monaco , et al. · 2025

The MSRSGC is an effective method for risk stratification of indeterminate salivary gland FNAs in pediatric patients. Each indeterminate MSRSGC category was associated with a specific range of ROM which was higher for AUS and SM in childre…

A Fatal Cascade Following Endoscopic Retrograde Cholangiopancreaticography (ERCP) Complicated by Pancreatitis, Duodenal Perforation, Gastrointestinal Hemorrhage, and Multi-organ Failure Open

Sharath Rajagopalan, Vikash Kumar, Bharath Bhushan, Leonard R Maier, Eric C. Huang · 2025

TI‐RADS and Bethesda Classification System Correlate With Predicting Pediatric Papillary Thyroid Carcinoma Open

Shaunak N. Amin, Megan Branson, J. Nathaniel Perkins, Xing Wang, Eric C. Huang , et al. · 2025

Objective Our study objectives were to evaluate the relationship between Thyroid Imaging Reporting and Data System (TI‐RADS) and Bethesda classification and to compare both TI‐RADS and Bethesda classification for the diagnosis of papillary…

Clozapine-Induced Acute Pericarditis and Cardiac Tamponade: Early Recognition Improves Clinical Outcomes Open

Muhammad Waqar Elahi, David E. Shi, Eric C. Huang, Bharath Bhushan · 2025

Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer Open

Heather A. Hartmann, Matthew A Loberg, George J Xu, Anna Schwarzkopf, Sheau‐Chiann Chen , et al. · 2025

Tenascin-C (TNC) is a secreted extracellular matrix protein that is highly expressed during embryonic development and re-expressed during wound healing, inflammation, and neoplasia. Studies in developmental models suggest that TNC may regu…

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations Open

Matthew A. Loberg, George Xu, Sheau‐Chiann Chen, Hua‐Chang Chen, Claudia C. Wahoski , et al. · 2025

Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic thyroid carcinoma is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an inte…

Tenascin-C potentiates Wnt signaling in thyroid cancer Open

Heather A. Hartmann, Matthew A Loberg, George J Xu, Anna Schwarzkopf, Sheau‐Chiann Chen , et al. · 2024

Tenascin-C (TNC) is a secreted extracellular matrix protein that is highly expressed during embryonic development and re-expressed during wound healing, inflammation, and neoplasia. Studies in developmental models suggest that TNC may regu…

Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction Open

George Xu, Matthew A. Loberg, Jean‐Nicolas Gallant, Quanhu Sheng, Sheau‐Chiann Chen , et al. · 2023

Genomic and transcriptomic analysis has furthered our understanding of many tumors. Yet, thyroid cancer management is largely guided by staging and histology, with few molecular prognostic and treatment biomarkers. Here, we utilize a large…

Simulated fine-needle aspiration diagnosis of follicular thyroid nodules by hyperspectral Raman microscopy and chemometric analysis Open

Marcos A. Soares de Oliveira, Michael J. Campbell, Alaa Afify, Eric C. Huang, James W. Chan · 2022

Our findings indicate that hyperspectral Raman microscopy can potentially be developed into an ancillary test for analyzing single cells from thyroid FNA biopsies to better stratify "indeterminate" nodules and other cytologically challengi…

Validating cell‐free DNA from supernatant for molecular diagnostics on cytology specimens Open

Marie Perrone, Rebeca Alvarez, Tawnie Vo, Moon‐Wook Chung, David C. Chhieng , et al. · 2021

Background Cytology specimens are often used for biomarker testing in the setting of neoplasia. On occasion, formalin‐fixed paraffin‐embedded (FFPE) cell blocks unfortunately may not yield sufficient material for testing. Recent studies ha…

Raman-based cytopathology: an approach to improve diagnostic accuracy in medullary thyroid carcinoma Open

Marcos A. Soares de Oliveira, Michael J. Campbell, Alaa Afify, Eric C. Huang, James W. Chan · 2020

Medullary thyroid carcinoma (MTC) is a rare form of thyroid malignancy that can be diagnostically challenging on fine needle aspiration (FNA) cytology. Ancillary tests such as elevated serum or immunohistochemical positive calcitonin have …

Hyperspectral Raman microscopy can accurately differentiate single cells of different human thyroid nodules Open

Marcos A. Soares de Oliveira, Michael J. Campbell, Alaa Afify, Eric C. Huang, James W. Chan · 2019

We report on the use of line-scan hyperspectral Raman microscopy in combination with multivariate statistical analyses for identifying and classifying single cells isolated from clinical samples of human thyroid nodules based on their intr…

Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis Open

Yanhong Zhang, Xiuli Feng, Jin Zhang, Minyi Chen, Eric C. Huang , et al. · 2019

Front Matter: Volume 10881 Open

Dániel Farkas, Attila Tárnok, James Leary Editors, Ian Khaw, Abraham Thomas , et al. · 2019

Genetic Ablation of <i>Rbm38</i> Promotes Lymphomagenesis in the Context of Mutant p53 by Downregulating PTEN Open

Jin Zhang, Enshun Xu, Cong Ren, Hee Jung Yang, Yanhong Zhang , et al. · 2018

Mutant p53 exerts gain-of-function effects that drive metastatic progression and therapeutic resistance, but the basis for these effects remain obscure. The RNA binding protein RBM38 limits translation of mutant p53 and is often altered in…

87 Cytologic Characterization of Lymphomas in Body Fluids: A Retrospective Study at a Single Institution Open

Elham Vali Betts, Mingyi Chen, Eric C. Huang, Alaa Afify · 2018

Body cavities can be involved by lymphomas. Cytology not only provides a rapid preliminary diagnosis, but in conjunction with ancillary tests can also offer significant information on classification and prognosis of lymphomas. The objectiv…

Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner Open

Hee Jung Yang, Jin Zhang, Wensheng Yan, Seong-Jun Cho, Christopher A. Lucchesi , et al. · 2017

Significance Nerve injury-induced protein 1 (Ninj1), a p53 target, forms a feedback loop with p53 by repressing p53 translation. Here, we show that cell growth was enhanced by Ninj1 deficiency in cells carrying a mutant p53, but inhibited …

The Use of Endometrial Cancer Patient-Derived Organoid Culture for Drug Sensitivity Testing Is Feasible Open

Eugenia Girda, Gary S. Leiserowitz, Lloyd H. Smith, Eric C. Huang · 2017

The use of endometrial cancer PDO cultures for development of drug sensitivity testing for individual patient tumors is feasible. The potential value of the PDO model for clinical decision making will require clinical trial evaluation.

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2 Open

Yanhong Zhang, Yingjuan Qian, Jin Zhang, Wensheng Yan, Yong-Sam Jung , et al. · 2017

Ferredoxin reductase (FDXR), a target of p53, modulates p53-dependent apoptosis and is necessary for steroidogenesis and biogenesis of iron–sulfur clusters. To determine the biological function of FDXR, we generated a Fdxr -deficient mouse…

Integrin Alpha 9 Blockade Suppresses Lymphatic Valve Formation and Promotes Transplant Survival Open

Gyeong Jin Kang, Tan Truong, Eric C. Huang, Valerie L. Su, Shaokui Ge , et al. · 2016

Lymphatic valvulogenesis is critically involved in transplant rejection. Itga-9 targeting may offer a new and effective strategy to interfere with the immune responses and promote graft survival.

Abnormal placentation in caesarean scar ectopic pregnancy Open

Melissa J. Chen, Eric C. Huang, Melody Y. Hou · 2016

A multiparous woman aged 34 years with a prior low transverse caesarean delivery presented at 12 weeks gestation for nuchal translucency screening. She had an unremarkable ultrasound study at 8 weeks gestation. Although asymptomatic at her…

Integrin alpha 9 blockade promotes corneal transplant survival Open

Gyeong Jin Kang, Tan N. Truong, Eric C. Huang, Valerie L. Su, Shaokui Ge , et al. · 2016

p16ink4 and cytokeratin 7 immunostaining in predicting HSIL outcome for low-grade squamous intraepithelial lesions: a case series, literature review and commentary Open

Eric C. Huang, Mary Tomic, Suchanan Hanamornroongruang, Emily E. Meserve, Michaël Herfs , et al. · 2016

Pleural fluid metastases of myoepithelial carcinoma: A case report and review of the literature Open

Alicia Calderon Bhambra, Yanhong Zhang, Eric C. Huang, John W. Bishop, Mahan Matin , et al. · 2016

Myoepithelial carcinoma (MECA) is one of the rarest salivary gland neoplasms, which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The tumor occurs mainly in the parotid gland followe…

Histologic and clinical follow‐up of thyroid fine‐needle aspirates in pediatric patients Open

Kristen Partyka, Eric C. Huang, Harvey Cramer, Shaoxiong Chen, Howard H. Wu · 2016

BACKGROUND Although fine‐needle aspiration (FNA) has an important role in evaluating thyroid nodules in adults, there is little published information regarding its utility in the pediatric population. METHODS A retrospective analysis of th…

Synchronous uterine adenocarcinoma and leiomyosarcoma: A rare case report causing a clinical conundrum Open

Katie K. Crean, Eric C. Huang, Edwin Alvarez · 2016

BT-02 * FUNCTIONALLY-DEFINED THERAPEUTIC TARGETS IN DIFFUSE INTRINSIC PONTINE GLIOMA Open

C. S. Grasso, Yujie Tang, Nathalène Truffaux, Noah Berlow, Li Liu , et al. · 2015

Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal childhood cancer. Here, we performed a chemical screen in patient-derived DIPG cell cultures along with RNAseq expression analysis and integrated computational modeling to iden…

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