Eric Y. Chang
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View article: Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study
Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study Open
This study aims to demonstrate the feasibility of ultrashort echo time (UTE)-based susceptibility source separation for musculoskeletal (MSK) imaging, enabling discrimination between diamagnetic and paramagnetic tissue components, with a p…
View article: Comprehensive zonal assessment of meniscal degeneration using quantitative UTE MRI
Comprehensive zonal assessment of meniscal degeneration using quantitative UTE MRI Open
The study highlights the potential of UTE measurements to differentiate normal meniscal zonal composition and detect early changes due to degeneration, offering a promising tool for comprehensive knee-OA assessment and treatment monitoring.
View article: Assessment of White Matter Changes Using Quantitative T1ρ Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI)
Assessment of White Matter Changes Using Quantitative T1ρ Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI) Open
Blast-induced mild traumatic brain injury (mTBI) occurs when shock waves travel through blood vessels and cerebrospinal fluid, leading to cerebral demyelination, which results in cognitive impairments and neuropsychiatric issues that impac…
View article: Diffusion Tensor Imaging of Rat Rotator Cuff Muscle With Histopathological Correlation: An Exploratory Study
Diffusion Tensor Imaging of Rat Rotator Cuff Muscle With Histopathological Correlation: An Exploratory Study Open
The purpose of this exploratory study was to quantify the relationship between scalar‐based measures of diffusion tensor imaging (DTI) and histologically derived microstructural measurements in precisely colocalized rat rotator cuff muscle…
View article: 0557 Effects of a Cannabidiol/Terpene Formulation on Sleep in Individuals with Insomnia: A Double-Blind, Placebo-Controlled, Randomized, Crossover Study
0557 Effects of a Cannabidiol/Terpene Formulation on Sleep in Individuals with Insomnia: A Double-Blind, Placebo-Controlled, Randomized, Crossover Study Open
Introduction Cannabidiol (CBD) is increasingly used as a health supplement, though few clinical studies have demonstrated benefits. The primary objective of this study was to evaluate the effects of an oral CBD-terpene formulation on sleep…
View article: Novel fat suppression technique for ultrashort echo time MRI using single-point Dixon phase modeling
Novel fat suppression technique for ultrashort echo time MRI using single-point Dixon phase modeling Open
Our novel fat suppression technique has been shown to provide a fast, time-saving, and robust fat suppression for UTE imaging without the need for additional scans.
View article: UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study
UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study Open
Mild traumatic brain injury (mTBI) is a leading cause of long-term disability. Following mTBI, secondary chemical cascades and neuroinflammation can result in myelin damage, significantly impairing cognitive function. This study aims to as…
View article: UTE MRI technical developments and applications in osteoporosis: a review
UTE MRI technical developments and applications in osteoporosis: a review Open
Osteoporosis (OP) is a metabolic bone disease that affects more than 10 million people in the USA and leads to over two million fractures every year. The disease results in serious long-term disability and death in a large number of patien…
View article: Evaluation of the Femoral Condyle Radius of Curvature at the Chondral Surface Shows Significant Correlation With the Anterior-Posterior Length
Evaluation of the Femoral Condyle Radius of Curvature at the Chondral Surface Shows Significant Correlation With the Anterior-Posterior Length Open
Background Accurate donor-recipient matching of the femoral condyle radius of curvature (ROC) in osteochondral allograft (OCA) transplantation may aid in minimizing articular surface incongruities. Matching linear femorotibial dimensions, …
View article: A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice
A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice Open
Background Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays a critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability of its mRNA transcript, determined in par…
View article: Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury
Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury Open
Background and Purpose This study aims to assess the potential of ultrashort echo time imaging‐based magnetization transfer ratio (UTE‐MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open‐field …
View article: Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A D2O Exchange and Freeze-Drying Study
Are Collagen Protons Visible with the Zero Echo Time (ZTE) Magnetic Resonance Imaging Sequence: A D2O Exchange and Freeze-Drying Study Open
It is known that ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequences can detect signals from water protons but not collagen protons in short T2 species such as cortical bone and tendons. However, whether collagen protons …
View article: What Is the Prevalence of Hip Abductor Pathology in Patients Undergoing Total Hip Arthroplasty?
What Is the Prevalence of Hip Abductor Pathology in Patients Undergoing Total Hip Arthroplasty? Open
There is a high prevalence of hip abductor pathology in patients presenting for THA. Clinicians should evaluate patients for signs of abductor tendon pathology when presenting for consideration of THA. Careful examination and MRI may be he…
View article: Influences of Variability in Attenuation Compensation on the Estimation of Backscatter Coefficient of Median Nerves in Vivo
Influences of Variability in Attenuation Compensation on the Estimation of Backscatter Coefficient of Median Nerves in Vivo Open
Objective Peripheral nerves remain a challenging target for medical imaging, given their size, anatomical complexity, and structural heterogeneity. Quantitative ultrasound (QUS) applies a set of techniques to estimate tissue acoustic param…
View article: Longitudinal Imaging of Injured Spinal Cord Myelin and White Matter with 3D Ultrashort Echo Time Magnetization Transfer (UTE-MT) and Diffusion MRI
Longitudinal Imaging of Injured Spinal Cord Myelin and White Matter with 3D Ultrashort Echo Time Magnetization Transfer (UTE-MT) and Diffusion MRI Open
Quantitative MRI techniques could be helpful to noninvasively and longitudinally monitor dynamic changes in spinal cord white matter following injury, but imaging and postprocessing techniques in small animals remain lacking. Unilateral C5…
View article: Quantitative ultrashort echo time MR imaging of knee osteochondral junction: An ex vivo feasibility study
Quantitative ultrashort echo time MR imaging of knee osteochondral junction: An ex vivo feasibility study Open
Compositional changes can occur in the osteochondral junction (OCJ) during the early stages and progressive disease evolution of knee osteoarthritis (OA). However, conventional magnetic resonance imaging (MRI) sequences are not able to ima…
View article: Qualitative and Quantitative <scp>MR</scp> Imaging of the Cartilaginous Endplate: A Review
Qualitative and Quantitative <span>MR</span> Imaging of the Cartilaginous Endplate: A Review Open
The cartilaginous endplate (CEP) plays a pivotal role in facilitating the supply of nutrients and, transport of metabolic waste, as well as providing mechanical support for the intervertebral disc (IVD). Recent technological advances have …
View article: Significant age‐related differences between lower leg muscles of older and younger female subjects detected by ultrashort echo time magnetization transfer modeling
Significant age‐related differences between lower leg muscles of older and younger female subjects detected by ultrashort echo time magnetization transfer modeling Open
Magnetization transfer (MT) magnetic resonance imaging (MRI) can be used to estimate the fraction of water and macromolecular proton pools in tissues. MT modeling paired with ultrashort echo time acquisition (UTE‐MT modeling) has been prop…
View article: Ultrashort Echo Time, MRI porosity index, and suppression ratio correlate with the cortical bone microstructural and mechanical properties
Ultrashort Echo Time, MRI porosity index, and suppression ratio correlate with the cortical bone microstructural and mechanical properties Open
The cortical bone porous microstructure can be evaluated using ultrashort echo time (UTE) MRI. UTE-MRI-based evaluation of bone has been underutilized partly due to the high cost and time demands of MRI in general. The porosity index (PI) …
View article: Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative
Infrapatellar fat pad size and subcutaneous fat in knee osteoarthritis radiographic progression: data from the osteoarthritis initiative Open
Objectives Adipose tissue has been associated with knee osteoarthritis (KOA) pathogenesis, but the longitudinal changes in adipose tissue with KOA progression have not been carefully evaluated. This study aimed to determine if longitudinal…
View article: Extrapulmonary hyalinizing granuloma: a rare case with intra-articular and tenosynovial involvement
Extrapulmonary hyalinizing granuloma: a rare case with intra-articular and tenosynovial involvement Open
Extrapulmonary hyalinizing granuloma (EPHG) is a notably rare condition, representing an exaggerated chronic immune response to antigenic stimuli. This report presents the first documented case of intra-articular and tenosynovial EPHG with…
View article: Shoulder Bone Segmentation with DeepLab and U-Net
Shoulder Bone Segmentation with DeepLab and U-Net Open
Evaluation of the 3D bone morphology of the glenohumeral joint is necessary for pre-surgical planning. Zero echo time (ZTE) magnetic resonance imaging (MRI) provides excellent bone contrast and can potentially be used in the place of compu…
View article: 3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice
3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice Open
Purpose To test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model. Methods Non-aqueous myelin protons have ultrashort T 2 s and are “invisibl…
View article: Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis
Ultrashort echo time MRI detects significantly lower collagen but higher pore water in the tibial cortex of female patients with osteopenia and osteoporosis Open
Ultrashort echo time (UTE) MRI can quantify the major proton pool densities in cortical bone, including total (TWPD), bound (BWPD), and pore water (PWPD) proton densities, as well as the macromolecular proton density (MMPD), associated wit…