Eric Chapuy
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View article: 5‐ <scp>HT</scp> <sub>6</sub> Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5‐ <scp>HT</scp> <sub>6</sub> Receptor Constitutive Activity
5‐ <span>HT</span> <sub>6</sub> Receptor Inverse Agonists Modulate Diabetic Neuropathic Pain in Female Rats: Evidence for 5‐ <span>HT</span> <sub>6</sub> Receptor Constitutive Activity Open
Painful neuropathy is one of the most common complications of diabetes. First‐line therapeutic agents such as tricyclic antidepressants, dual serotonin/noradrenaline reuptake inhibitors, and alpha2‐delta ligands of calcium channels (i.e., …
View article: Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine
Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine Open
Blood biomarkers, including neurofilament light chain (NfL), have garnered attention as potential indicators for chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting adverse effect of neurotoxic anticancer drugs. However, no …
View article: The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats
The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats Open
Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and assoc…
View article: Analgesic and preventive effects of donepezil in animal models of chemotherapy-induced peripheral neuropathy: Involvement of spinal muscarinic acetylcholine M2 receptors
Analgesic and preventive effects of donepezil in animal models of chemotherapy-induced peripheral neuropathy: Involvement of spinal muscarinic acetylcholine M2 receptors Open
View article: TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects
TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects Open
Background and Purpose Opioids are effective painkillers. However, their risk–benefit ratio is dampened by numerous adverse effects and opioid misuse has led to a public health crisis. Safer alternatives are required, but isolating the ant…
View article: mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment
mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment Open
View article: Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity
Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity Open
Recent studies have revealed gender differences in cold perception, and pointed to a possible direct action of testosterone (TST) on the cold‐activated TRPM8 (Transient Receptor Potential Melastatin Member 8) channel. However, the mechanis…
View article: Development of\nthe First Two-Pore Domain Potassium\nChannel TWIK-Related K<sup>+</sup> Channel 1‑Selective Agonist\nPossessing in Vivo Antinociceptive Activity
Development of\nthe First Two-Pore Domain Potassium\nChannel TWIK-Related K<sup>+</sup> Channel 1‑Selective Agonist\nPossessing in Vivo Antinociceptive Activity Open
The\nTWIK-related K+ channel, TREK-1, has recently emerged\nas an attractive therapeutic target for the development of a novel\nclass of analgesic drugs, suggesting that activation of TREK-1 could\nresult in pain inhibition. Her…
View article: The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia
The Nav1.9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia Open