Explanipedia

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma Open

Daniel Angelov, James P. Nolan, Gráinne Holland, Darragh Nimmo, Molly Davies , et al. · 2025

The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. EZH2 inhibitors provide clinical benefi…

Dominant-negative effects of Weaver syndrome-associated EZH2 variants Open

Orla Deevy, Jingjing Li, Craig Monger, Francesca Matrà, Ellen Tuck , et al. · 2025

Heterozygous missense mutations in EZH2 cause Weaver syndrome (WS), a developmental disorder characterized by intellectual disability and overgrowth. EZH2 encodes the enzymatic subunit of Polycomb repressive complex 2 (PRC2), which mediate…

THE TNF SUPERFAMILY FACTOR TWEAK PROMOTES TRAINED IMMUNITY ASSOCIATED WITH PERSISTENT HISTONE MODIFICATIONS IN INTESTINAL FIBROBLASTS Open

Carlos Pastor‐Vargas, Emma Doyle, Carlos Matellan, Cian Ohlendieck, M Nwaezeigwe , et al. · 2025

INTRODUCTION The ability of innate immune cells to acquire transient memory after an inflammatory insult is an immuno-regulatory mechanism associated to epigenetic regulation and known as trained immunity. Intestinal fibroblasts may acquir…

A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells Open

Rachel McCole, James Nolan, David M Reck, Craig Monger, Samantha Rustichelli , et al. · 2025

Polycomb repressive complex 2 (PRC2), composed of the core subunits EED, SUZ12, and either EZH1 or EZH2, is critical for maintaining cellular identity in multicellular organisms. PRC2 deposits H3K27me3, which is thought to recruit the cano…

Short circuit: Transcription factor addiction as a growing vulnerability in cancer Open

Molly Davies, Maeve Boyce, Eric Conway · 2024

Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants Open

Orla Deevy, Craig Monger, Francesca Matrà, Ellen Tuck, Eric Conway , et al. · 2023

Heterozygous missense mutations in EZH2 cause Weaver syndrome (WS), a developmental disorder characterized by intellectual disability and overgrowth. EZH2 encodes the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which mediate…

Know when to fold ‘em: Polycomb complexes in oncogenic 3D genome regulation Open

Emma J. Doyle, Lluís Morey, Eric Conway · 2022

Chromatin is spatially and temporally regulated through a series of orchestrated processes resulting in the formation of 3D chromatin structures such as topologically associating domains (TADs), loops and Polycomb Bodies. These structures …

BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation Open

Eric Conway, Federico Rossi, Daniel Fernández-Pérez, Eleonora Ponzo, Karin Johanna Ferrari , et al. · 2021

BAP1 activity regulates PcG occupancy and global chromatin condensation counteracting diffuse PCGF3/5-dependent H2AK119ub1 deposition Open

Eric Conway, Federico Rossi, Simone Tamburri, Eleonora Ponzo, Karin Johanna Ferrari , et al. · 2020

BAP1 is recurrently mutated or deleted in a large number of diverse cancer types, including mesothelioma, uveal melanoma and hepatocellular cholangiocarcinoma. BAP1 is the catalytic subunit of the Polycomb Repressive De-Ubiquitination comp…

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression Open

Simone Tamburri, Elisa Lavarone, Daniel Fernández-Pérez, Eric Conway, Marika Zanotti , et al. · 2019

Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. PRC1 and PRC2 e…

PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation Open

Evan Healy, Marlena Mucha, Eleanor Glancy, Darren J. Fitzpatrick, Eric Conway , et al. · 2019

Histone H2AK119 Mono-Ubiquitination is Essential for Polycomb-Mediated Transcriptional Repression Open

Simone Tamburri, Elisa Lavarone, Daniel Fernández-Pérez, Marika Zanotti, Daria Manganaro , et al. · 2019

The major function of Polycomb group proteins (PcG) is to maintain transcriptional repression to preserve cellular identity. This is exerted by two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1…

A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities Open

Eric Conway, Emilia Jerman, Evan Healy, Shinsuke Ito, Daniel Holoch , et al. · 2018

The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells Open

Gundula Streubel, Ariane Watson, Sri Ganesh Jammula, Andrea Scelfo, Darren J. Fitzpatrick , et al. · 2018

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence Open

Gerard L. Brien, Evan Healy, Emilia Jerman, Eric Conway, Elisa Fadda , et al. · 2015

Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such app…

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