Eric D. Spitzer
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View article: A Prospective Cohort Longitudinal Study of Human Acute Babesiosis: Quality of Life and Severity of Symptoms Through 1-Year Follow-up
A Prospective Cohort Longitudinal Study of Human Acute Babesiosis: Quality of Life and Severity of Symptoms Through 1-Year Follow-up Open
Background Babesiosis, caused by the parasitic blood-borne piroplasm Babesia microti, is emerging in the Northern hemisphere. We aimed to study long-term symptoms of patients with B microti infection in New York. Methods A prospective long…
View article: Cover crop potential of pea lines derived from crosses with nodulation mutants
Cover crop potential of pea lines derived from crosses with nodulation mutants Open
Over the past century, numerous studies have addressed the physiology and genetics of biological nitrogen fixation (BNF) in legumes—targeting improvements through screening of existing germplasm, hybridization, and mutagenesis. Although th…
View article: P-1325. Quality of Life and Severity of Symptoms in 1-year Follow Up of Patients Presenting with Acute Babesiosis: A Prospective Cohort Study with Validated Questionnaire
P-1325. Quality of Life and Severity of Symptoms in 1-year Follow Up of Patients Presenting with Acute Babesiosis: A Prospective Cohort Study with Validated Questionnaire Open
Background Tick-borne diseases are a growing public health concern in the US, particularly in New York. Babesia microti, a parasitic blood-borne piroplasm, causes the disease Babesiosis in humans. The aim of this prospective cohort study i…
View article: P-1850. Acute <i>Babesia microti</i> Infection in Humans Is Associated With Marked Changes In The Expression Of Peripheral Blood Coding And Noncoding RNA
P-1850. Acute <i>Babesia microti</i> Infection in Humans Is Associated With Marked Changes In The Expression Of Peripheral Blood Coding And Noncoding RNA Open
Background Babesiosis is a potentially life-threatening disease transmitted by ticks. However, host and parasite determinants of human babesiosis are completely unknown. In the current study we evaluated the impact of B. microti infection,…
View article: 270. RhD negative Blood Type is Associated with Higher Levels of <i>Babesia microti</i> Parasitemia and May Be a Useful Point-of-Care Biomarker in Human Babesiosis
270. RhD negative Blood Type is Associated with Higher Levels of <i>Babesia microti</i> Parasitemia and May Be a Useful Point-of-Care Biomarker in Human Babesiosis Open
Background There is a growing need to identify novel point-of-care biomarkers that correlate with clinical presentation in the study of babesiosis. Recently, Jajosky et al (2023, PMID: 36696414) demonstrated that in patients with babesiosi…
View article: 1788. High Ferritin Levels in Hospitalized Patients with Acute Babesiosis in a Tertiary Medical Center in Long Island, NY (2014-2022)
1788. High Ferritin Levels in Hospitalized Patients with Acute Babesiosis in a Tertiary Medical Center in Long Island, NY (2014-2022) Open
Background Babesiosis, an intra-erythrocytic protozoan disease caused by Babesia spp, is an emerging zoonotic parasitic disease worldwide. Our group have recently described the utility of biomarkers such as lipid profile and procalcitonin …
View article: Neurologic Manifestations of Tick-Borne Diseases Transmitted by Deer Ticks (Ixodes scapularis) in the USA
Neurologic Manifestations of Tick-Borne Diseases Transmitted by Deer Ticks (Ixodes scapularis) in the USA Open
Purpose of Review This article aims to review the relevant updates in pathogenesis, diagnostics, clinical manifestations, and treatments of tick-borne diseases involving the nervous system, with special emphasis on emerging viral and bacte…
View article: Reduced Cholesterol Levels during Acute Human Babesiosis
Reduced Cholesterol Levels during Acute Human Babesiosis Open
Background: Babesiosis, an intra-erythrocytic protozoan disease, is an emerging zoonotic parasitic disease worldwide. Cholesterol levels are correlated with severe infections, such as sepsis and COVID-19, and anecdotal reports suggest that…
View article: False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021 Open
Cases of rocky mountain spotted fever (RMSF) are increasingly reported every year in Long Island, New York. In clinical practice, an uncommonly high number of referrals with a positive RMSF IgG test result have been seen in our tick-borne …
View article: 367. Procalcitonin as a Potential Biomarker in the Study of Human Babesiosis
367. Procalcitonin as a Potential Biomarker in the Study of Human Babesiosis Open
Background Procalcitonin (Pct) has been gaining momentum as a potential biomarker during parasitic infections as studies have demonstrated that Pct levels are significantly elevated during certain forms of protozoal sepsis. Given this, the…
View article: 507. Peripheral blood RNA signatures associated with human babesiosis, quality of life and neurological symptoms
507. Peripheral blood RNA signatures associated with human babesiosis, quality of life and neurological symptoms Open
Background Human babesiosis is an emerging tick-borne disease in the US that is primarily caused by the protozoan Babesia microti (Bm). Although Babesiosis can cause life-threatening infections, the pathophysiology including host and paras…
View article: Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused by B. microti
Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused by B. microti Open
Procalcitonin is gaining momentum in the study of protozoal sepsis, but its utility as a biomarker has yet to be fully discovered in human babesiosis. A total of 33 cases of acute babesiosis dating between 2012 and 2019 were retrospectivel…
View article: A Short Series of Case Reports of COVID-19 in Immunocompromised Patients
A Short Series of Case Reports of COVID-19 in Immunocompromised Patients Open
Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants of SARS-CoV-2. Nonetheless, limited data are av…
View article: 734. Abnormal Lipid Profiles in Human Babesiosis
734. Abnormal Lipid Profiles in Human Babesiosis Open
Background Babesiosis has gained attention as an emerging protozoal zoonotic disease with an expanding known incidence and geographical range in the US. The infection is caused by Babesia microti in the US and is transmitted by the bite of…
View article: Prevalence of IgM and IgG antibodies to SARS-CoV-2 in health care workers at a tertiary care New York hospital during the Spring COVID-19 surge
Prevalence of IgM and IgG antibodies to SARS-CoV-2 in health care workers at a tertiary care New York hospital during the Spring COVID-19 surge Open
Background Health care workers (HCW) such as anesthesiologists, surgeons, and intensivists face high rates of exposure to SARS-CoV-2 through direct contact with COVID-19 patients. While there are initial reports of the prevalence of COVID-…
View article: Multidisciplinary Response to Nosocomial Influenza
Multidisciplinary Response to Nosocomial Influenza Open
Background: Nosocomial influenza infections can be caused by direct patient-to-patient transmission, as well as bidirectionally between patient and healthcare workers (HCWs). Lapses in infection control practices (droplet precautions), and…
View article: Review of Viral Testing (Polymerase Chain Reaction) and Antibody/Serology Testing for Severe Acute Respiratory Syndrome-Coronavirus-2 for the Intensivist
Review of Viral Testing (Polymerase Chain Reaction) and Antibody/Serology Testing for Severe Acute Respiratory Syndrome-Coronavirus-2 for the Intensivist Open
Objective: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management. To describe to clinicians how each assay is performed, what…
View article: 214. Comparison of Clinical and Laboratory Findings of Human Monocytic Ehrlichiosis (HME) and Human Granulocytic Anaplasmosis (HGA) in Long Island, New York.
214. Comparison of Clinical and Laboratory Findings of Human Monocytic Ehrlichiosis (HME) and Human Granulocytic Anaplasmosis (HGA) in Long Island, New York. Open
Background Suffolk County reports to the Department of Health the highest absolute number of cases of tick-borne diseases (TBD) for NY State. While Lyme disease and Babesiosis are the most common TBD in this county with more than 600 and 1…
View article: 2799. Inability to Locally Differentiate Rhinovirus/Enterovirus Results Impacts Infection Control Practices
2799. Inability to Locally Differentiate Rhinovirus/Enterovirus Results Impacts Infection Control Practices Open
Background Rhinoviruses and Enteroviruses are closely related members of the family picornavirideae; however, they have distinct clinical manifestations. Rhinoviruses cause respiratory infections while Enteroviruses often present as nonspe…
View article: External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program
External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program Open
To the Editor.—We agree with Chandler et al1 that platelet function assays present a unique challenge for proficiency testing because the tests require fresh blood containing functional platelets with limited stability. Laboratories are re…
View article: 665. Key Clinical and Laboratory Features in Early Diagnosis of Ehrlichiosis in an Endemic Area of Long Island, New York
665. Key Clinical and Laboratory Features in Early Diagnosis of Ehrlichiosis in an Endemic Area of Long Island, New York Open
Background Human monocytic ehrlichiosis (HME) is a tick-borne disease caused by Ehrlichia chafeensis in the northeast United States. Suffolk County, New York has the highest amount of HME cases in NY (176 from 2010 to 2014). Our aim is to …
View article: 667. An Emerging Tick-Borne Disease in Long Island, New York: Relapsing Fever Caused by Borrelia miyamotoi
667. An Emerging Tick-Borne Disease in Long Island, New York: Relapsing Fever Caused by Borrelia miyamotoi Open
Background Suffolk County (Long Island, New York) reports annually the highest absolute number of tick-borne diseases in New York. A new Borrelia species, Borrelia miyamotoi which causes a relapsing fever, has been reported in New York rec…
View article: <i>Mycobacterium orygis</i> Lymphadenitis in New York, USA
<i>Mycobacterium orygis</i> Lymphadenitis in New York, USA Open
We report a case of lymphadenitis caused by Mycobacterium orygis in an immunocompetent person in Stony Brook, New York, USA. Initial real-time PCR assay failed to provide a final subspecies identification within the M. tuberculosis complex…
View article: Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone Open
Symptomatic babesiosis is still rare even in endemic regions. Recommended treatment regimen is well tolerated and effective. Compared to historical controls we observed a lower overall mortality.
View article: MRSA Causing Infections in Hospitals in Greater Metropolitan New York: Major Shift in the Dominant Clonal Type between 1996 and 2014
MRSA Causing Infections in Hospitals in Greater Metropolitan New York: Major Shift in the Dominant Clonal Type between 1996 and 2014 Open
A surveillance study in 1996 identified the USA100 clone (ST5/SCCmecII)–also known as the “New York/Japan” clone—as the most prevalent MRSA causing infections in 12 New York City hospitals. Here we update the epidemiology of MRSA in seven …
View article: Repeat<i>Clostridium difficile</i>PCR Testing After a Negative ResultThe Authors’ Reply
Repeat<i>Clostridium difficile</i>PCR Testing After a Negative ResultThe Authors’ Reply Open
In their study of the short-term risk of acquisition of Clostridium difficile in hospitalized patients, Aldrete et al1 observed that 30 of 1,500 patients who had repeat C difficile polymerase chain reaction (PCR) tests within 14 days conve…