Eric de Hoog
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View article: Arc mediates intercellular tau transmission via extracellular vesicles
Arc mediates intercellular tau transmission via extracellular vesicles Open
Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau relea…
View article: Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System
Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System Open
Retinoic acid, the active metabolite of Vitamin A, is important for the appropriate development of the nervous system (e.g., neurite outgrowth) as well as for cognition (e.g., memory formation) in the adult brain. We have shown that many o…
View article: The role of retinoic acid in the formation and modulation of invertebrate central synapses
The role of retinoic acid in the formation and modulation of invertebrate central synapses Open
Trophic factors can influence many aspects of nervous system function, such as neurite outgrowth, synapse formation, and synapse modulation. The vitamin A metabolite, retinoic acid, can exert trophic effects to promote neuronal survival an…