Eric Denbaum
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View article: Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants Open
RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target thi…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis
Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis Open
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). A…
View article: Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies Open
The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosphorylation of the necroptotic effector pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by the upstream pr…