Eric Denkers
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View article: Influence of MyD88 and αβ T cells on mesenteric lymph node innate lymphoid cell populations during Toxoplasma gondii infection
Influence of MyD88 and αβ T cells on mesenteric lymph node innate lymphoid cell populations during Toxoplasma gondii infection Open
First encounter of Toxoplasma with the host immune system occurs within tissues of the intestine, including the intestinal mucosa and draining lymph nodes. In this study, we focused on the mesenteric lymph node compartment, the central hub…
View article: T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by <i>Toxoplasma gondii</i> GRA24
T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by <i>Toxoplasma gondii</i> GRA24 Open
As a model organism in the study of immunity to infection, Toxoplasma gondii has been instrumental in establishing key principles of host anti-microbial defense and its regulation. Here, we employed an attenuated uracil auxotroph strain of…
View article: Impact of MyD88, Microbiota, and Location on Type 1 and Type 3 Innate Lymphoid Cells during <i>Toxoplasma gondii</i> Infection
Impact of MyD88, Microbiota, and Location on Type 1 and Type 3 Innate Lymphoid Cells during <i>Toxoplasma gondii</i> Infection Open
Toxoplasma gondii induces strong IFN-γ–based immunity. Innate lymphoid cells (ILC), in particular ILC1, are an important innate source of this protective cytokine during infection. Our objective was to determine how MyD88-dependent signali…
View article: Impact of IFN‐y and CD40 signalling on <i>Toxoplasma gondii</i> cyst formation in differentiated Neuro‐2a neuroblastoma cells
Impact of IFN‐y and CD40 signalling on <i>Toxoplasma gondii</i> cyst formation in differentiated Neuro‐2a neuroblastoma cells Open
Signalling by IFN‐y and CD40 is known to trigger anti‐microbial activity in macrophages infected with Toxoplasma gondii , but their effects on infected neurons are less well known. Here, we compared how stimulation with IFN‐y and an agonis…
View article: Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade
Induction of IL-12p40 and type 1 immunity by Toxoplasma gondii in the absence of the TLR-MyD88 signaling cascade Open
Toxoplasma gondii is an orally acquired pathogen that induces strong IFN-γ based immunity conferring protection but that can also be the cause of immunopathology. The response in mice is driven in part by well-characterized MyD88-dependent…
View article: From Initiators to Effectors: Roadmap Through the Intestine During Encounter of Toxoplasma gondii With the Mucosal Immune System
From Initiators to Effectors: Roadmap Through the Intestine During Encounter of Toxoplasma gondii With the Mucosal Immune System Open
The gastrointestinal tract is a major portal of entry for many pathogens, including the protozoan parasite Toxoplasma gondii . Billions of people worldwide have acquired T. gondii at some point in their life, and for the vast majority this…
View article: Additional file 12 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88
Additional file 12 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88 Open
Additional file 12 Complete list of differentially expressed Toxoplasma gondii genes. The first tab corresponds to wild type RH versus wild type PTG. The second tab corresponds to Myd88KO RH versus Myd88KO PTG. The third tab lists the diff…
View article: Additional file 6 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88
Additional file 6 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88 Open
Additional file 6. Complete list of differentially regulated mouse protein-coding genes in MyD88+/+ and MyD88−/− BMDM. Each tab in the spreadsheet corresponds to a specific pairwise comparison (e.g., RH vs. uninfected). Transcript name, Ge…
View article: Additional file 7 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88
Additional file 7 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88 Open
Additional file 7. Functional analysis of differentially expressed protein-coding genes. Each tab in the spreadsheet corresponds to a specific pairwise comparison (e.g., RH vs. uninfected). Results were obtained using g:Profiler. Gene Onto…
View article: Additional file 10 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88
Additional file 10 of Transcriptomics analysis of Toxoplasma gondii-infected mouse macrophages reveals coding and noncoding signatures in the presence and absence of MyD88 Open
Additional file 10. Complete list of differentially expressed mouse non-coding genes. Each tab in the spreadsheet corresponds to a specific pairwise comparison (e.g., RH vs. uninfected). Transcript name, Gene IDs, raw values, normalized va…
View article: CCR2 and CD44 Promote Inflammatory Cell Recruitment during Fatty Liver Formation in a Lithogenic Diet Fed Mouse Model
CCR2 and CD44 Promote Inflammatory Cell Recruitment during Fatty Liver Formation in a Lithogenic Diet Fed Mouse Model Open
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a spectrum of presentations. The current study utilized a lithogenic diet model of NAFLD. The diet was fed to mice that are either resistant (AKR) or susceptible (BALB/c an…
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Aims and scope.Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our un…
View article: Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity
Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity Open
The apicomplexan Toxoplasma gondii induces strong protective immunity dependent upon recognition by Toll-like receptors (TLR)11 and 12 operating in conjunction with MyD88 in the murine host. However, TLR11 and 12 proteins are not present i…
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Aims and scope.Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our un…
View article: Impact of Toxoplasma gondii Infection on Host Non-coding RNA Responses
Impact of Toxoplasma gondii Infection on Host Non-coding RNA Responses Open
As an intracellular microbe, Toxoplasma gondii must establish a highly intimate relationship with its host to ensure success as a parasite. Many studies over the last decade-and-a-half have highlighted how the host reshapes its immunoprote…
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Blood Rectum Control 1 UC patient 2Aims and scope.Clinical and Experimental Immunology is a top ranking, international journal publishing biologically signifi cant studies that have clinical relevance.The Journal is focused on Translationa…
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Issue Information Open
Aims and scope. Clinical and ExperimentalImmunology is a top ranking, international journal publishing biologically signifi cant studies that have clinical relevance.The Journal is focused on Translational Immunology and is amongst the for…
View article: Issue Information
Issue Information Open
Aims and scope. Clinical and ExperimentalImmunology is a top ranking, international journal publishing biologically signifi cant studies that have clinical relevance.The Journal is focused on Translational Immunology and is amongst the for…
View article: Issue Information
Issue Information Open
Aims and scope. Clinical and ExperimentalImmunology is a top ranking, international journal publishing biologically signifi cant studies that have clinical relevance.The Journal is focused on Translational Immunology and is amongst the for…
View article: Issue Information
Issue Information Open
Aims and scope. Clinical and ExperimentalImmunology is a top ranking, international journal publishing biologically signifi cant studies that have clinical relevance.The Journal is focused on Translational Immunology and is amongst the for…
View article: Epithelial Sel1L is required for the maintenance of intestinal homeostasis
Epithelial Sel1L is required for the maintenance of intestinal homeostasis Open
Inflammatory bowel disease (IBD) is an incurable chronic idiopathic disease that drastically decreases quality of life. Endoplasmic reticulum (ER)–associated degradation (ERAD) is responsible for the clearance of misfolded proteins; howeve…
View article: Impact of <i>Toxoplasma gondii</i> on Dendritic Cell Subset Function in the Intestinal Mucosa
Impact of <i>Toxoplasma gondii</i> on Dendritic Cell Subset Function in the Intestinal Mucosa Open
The function of mucosal dendritic cell (DC) subsets in immunity and inflammation is not well understood. In this study, we define four DC subsets present within the lamina propria and mesenteric lymph node compartments based on expression …