Eric Deprez
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View article: Inhibition of HIV-1 replication by primer RNA packaging inhibitors
Inhibition of HIV-1 replication by primer RNA packaging inhibitors Open
An essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1) is the packaging of tRNA 3 Lys during viral assembly. This step, which requires the assembly of a ternary complex consisting of GagPol, mitochondrial lysyl-…
View article: Breaking Bonds by Light: The Absorbance–Fragmentation Paradox
Breaking Bonds by Light: The Absorbance–Fragmentation Paradox Open
Multi‐branched probes based on 2‐hydroxymethylene 8‐dimethylaminoquinoline (8‐DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near‐infrared two‐photon (2P) activation conditions. While octupolar (…
View article: Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery
Triphenylamine Sensitized 8‐Dimethylaminoquinoline: An Efficient Two‐Photon Caging Group for Intracellular Delivery Open
Triphenylamine‐sensitized 8‐dimethylaminoquinoline (TAQ) probes showed fair two‐photon absorption and fragmentation cross sections in releasing kainate and GABA ligands. The water‐soluble PEG and TEG‐analogs allowed cell internalization an…
View article: The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection Open
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here…
View article: The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection Open
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here…
View article: Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration Open
Our work highlights the role of HIV-1 unintegrated viral DNA in viral replication. A virus, resistant to strand-transfer inhibitors, has been selected in vitro . This virus highlights a mutation in the 3'PPT region and not in the integrase…
View article: Modulation of Cellular Fate of Vinyl Triarylamines through Structural Fine Tuning: To Stay or Not To Stay in the Mitochondria?
Modulation of Cellular Fate of Vinyl Triarylamines through Structural Fine Tuning: To Stay or Not To Stay in the Mitochondria? Open
Mitochondria are involved in many cellular pathways and dysfunctional mitochondria are linked to various diseases. Hence efforts have been made to design mitochondria‐targeted fluorophores for monitoring the mitochondrial status. However, …
View article: Design of Light-Sensitive Triggers for Endothelial NO-Synthase Activation
Design of Light-Sensitive Triggers for Endothelial NO-Synthase Activation Open
A specific light trigger for activating endothelial Nitric Oxide-Synthase (eNOS) in real time would be of unique value to decipher cellular events associated with eNOS activation or to generate on demand cytotoxic levels of NO at specific …
View article: Interplay between Intrinsic and Innate Immunity during HIV Infection
Interplay between Intrinsic and Innate Immunity during HIV Infection Open
Restriction factors are antiviral components of intrinsic immunity which constitute a first line of defense by blocking different steps of the human immunodeficiency virus (HIV) replication cycle. In immune cells, HIV infection is also sen…
View article: Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance
Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance Open
Our results indicate that the stability of STI IN/DNA complexes is an important parameter that must be taken into account when evaluating dolutegravir resistance. This study confirms that a pathway including N155H can be selected in patien…
View article: Different Pathways Leading to Integrase Inhibitors Resistance
Different Pathways Leading to Integrase Inhibitors Resistance Open
Integrase strand-transfer inhibitors (INSTIs), such as raltegravir (RAL), elvitegravir, or dolutegravir (DTG), are efficient antiretroviral agents used in HIV treatment in order to inhibit retroviral integration. By contrast to RAL treatme…
View article: Triphenylamines Induce Cell Death Upon 2-Photon Excitation
Triphenylamines Induce Cell Death Upon 2-Photon Excitation Open
Photodynamic therapy (PDT) is a promising therapeutic method for several diseases, in particular for cancer. This approach uses a photosensitizer, oxygen, and an external light source to produce reactive oxygen species (ROS) at lethal dose…
View article: Mechanistic insight into cadmium-induced inactivation of the Bloom protein
Mechanistic insight into cadmium-induced inactivation of the Bloom protein Open
Cadmium is a toxic metal that inactivates DNA-repair proteins via multiple mechanisms, including zinc substitution. In this study, we investigated the effect of Cd 2+ on the Bloom protein (BLM), a DNA-repair helicase carrying a zinc-bindin…
View article: The<i>Bacteroides sp. 3_1_23</i>Pif1 protein is a multifunctional helicase
The<i>Bacteroides sp. 3_1_23</i>Pif1 protein is a multifunctional helicase Open
ScPif1 DNA helicase is the prototypical member of a 5'-to-3' helicase superfamily conserved from bacteria to human and plays various roles in the maintenance of genomic homeostasis. While many studies have been performed with eukaryotic Pi…
View article: 353. New Insights of Microbubbles-Cell Interactions During Sonoporation Process
353. New Insights of Microbubbles-Cell Interactions During Sonoporation Process Open
Upon ultrasound (US) exposure, gas microbubbles (MBs) can be expanded, moved and even destroyed. These properties offer the opportunity of site-specific local drug/gene delivery. Activation of MB under specific US beams induces a transient…
View article: How the morphologies of progenitor and mature osteocytes contributes to their mechanotransduction
How the morphologies of progenitor and mature osteocytes contributes to their mechanotransduction Open
A dual experimental and numerical top-down approach is applied to investigate the
\nlink between the osteocyte morphology and their mechanical perception of the environment at
\nthe progenitor and mature stages. The numerical model is base…