Eric E. Irons
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View article: Figure 2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
APE2 conditional transgenic mouse model. A, Schematic diagram of the hAPE2LSL/LSL conditional transgenic mouse model. B, Representative images of APE2 immunofluorescence staining from OHCs of Prestin-CreERT2+/−hAPE2LSL/− mice 7 days after …
View article: Figure S4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure S4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Figure S4
View article: Figure S1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure S1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Figure S1
View article: Supplementary methods from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Supplementary methods from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Supplementary methods
View article: Figure S3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure S3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Figure S3
View article: Figure 1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Cisplatin treatment results in APE2 upregulation and mitochondrial dysmorphology in cochlear hair cells. A, IHC analysis of APE2 and MYH9 expression in cochlear tissues from patients with C-HL (n = 2) and normal donors (n = 1). OHCs are hi…
View article: Figure 5 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 5 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
APE2 knockdown mitigates cisplatin-induced apoptosis in vitro.A, Knockdown of APE2 by transfection of APE2 ASO and GFP ASO as control ASO gapmers in HEI-OC1 cells. B, Flow cytometry dot plots showing Annexin V and propidium iodide staining…
View article: Table 1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Table 1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
LS/MS analyses of APE2 pull-down proteins
View article: Figure 4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
APE2 binds to the MYH9 E853–A922 domain. A, Confocal images of HEI-OC1 cells after treatment with 250 ng/mL cisplatin at indicated time points, with DAPI (blue), APE2 (green), ATP5A (mitochondria, red), and MYH9 (magenta). Areas of condens…
View article: Figure 3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Clinical features of C-HL–like disease in APE2 transgenic mice. A, ABR thresholds, (B) DPOAE amplitudes, and (C) immunofluorescence staining (scale bar, 50 μm). D, Scanning electron microscopy (scale bar, 10 μm) in Prestin-ERT2Cre+/−hAPE2L…
View article: Figure 7 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 7 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
APE2 inhibits p53 signaling and provokes apoptosis. HEI-OC1 cells were transfected with indicated ASO 24 hours prior to further treatments. A, Cells were treated with 1 μg/mL or 5 μg/mL cisplatin for 6 hours prior to collection of total ce…
View article: Figure S2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure S2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Figure S2
View article: Figure 6 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Figure 6 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
APE2 ASO restores mitochondrial respiration impaired by cisplatin treatment. A, Seahorse XF analysis of the mitochondrial OCR in cells transfected with control GFP ASO or APE2 ASO. Key parameters measured include basal respiration, ATP-lin…
View article: Data from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Data from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Cisplatin remains a cornerstone chemotherapy for many solid tumors but is limited by dose-limiting toxicities, including nephrotoxicity, peripheral neuropathy, and ototoxicity—the latter of which disproportionately affects pediatric patien…
View article: Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss Open
Cisplatin remains a cornerstone chemotherapy for many solid tumors but is limited by dose-limiting toxicities, including nephrotoxicity, peripheral neuropathy, and ototoxicity—the latter of which disproportionately affects pediatric patien…
View article: Superwarfarin Rodenticide Poisoning due to Consumption of Exotic Animals: A Case Report
Superwarfarin Rodenticide Poisoning due to Consumption of Exotic Animals: A Case Report Open
Poisoning from superwarfarin rodenticides should be considered in patients with unexplained bleeding due to vitamin K deficiency, with no other history of coagulopathy or anticoagulant use. A 37‐year‐old man originally presented to our hos…
View article: Sialic Acid in the Regulation of Blood Cell Production, Differentiation, and Turnover
Sialic Acid in the Regulation of Blood Cell Production, Differentiation, and Turnover Open
Sialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying stru…
View article: Sialic acid in the regulation of blood cell production, differentiation and turnover
Sialic acid in the regulation of blood cell production, differentiation and turnover Open
Sialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying stru…
View article: Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice
Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice Open
Interactions between the neonate host and its gut microbiome are central to the development of a healthy immune system. However, the mechanisms by which animals alter early colonization of microbiota for their benefit remain unclear. Here,…
View article: Bacterial Colonization and TH17 Immunity are Shaped by Intestinal Sialylation in Neonatal Mice
Bacterial Colonization and TH17 Immunity are Shaped by Intestinal Sialylation in Neonatal Mice Open
Background: Interactions between the neonate host and its gut microbiome are central to the development of a healthy immune system. However, the mechanisms by which animals alter early colonization of microbiota for their benefit remain un…
View article: Bacterial Colonization and Th17 Immunity are Shaped by Intestinal Sialylation in Neonatal Mice
Bacterial Colonization and Th17 Immunity are Shaped by Intestinal Sialylation in Neonatal Mice Open
Background: Interactions between the neonate host and its gut microbiome are central to the development of a healthy immune system. However, the mechanisms by which animals alter early colonization of microbiota for their benefit remain un…
View article: Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells Open
Humoral immunity is an effective but metabolically expensive defense mechanism. It is unclear whether systemic cues exist to communicate the dynamic need for antigen presentation and immunoglobulin production. Here, we report a novel role …
View article: The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage Open
High-dose irradiation poses extreme risk of mortality from acute damage to the hematopoietic compartment and gastrointestinal tract. While bone marrow transplantation can reestablish the hematopoietic compartment, a more imminent risk of d…
View article: B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism
B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism Open
The immune response relies on the integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the marrow during emergency granulopoiesis but return upon restoration of homeostasis. Here we report a no…
View article: B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism
B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism Open
The immune response relies on the timely integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the bone marrow for the emergency generation of granulocytes. However, it is unclear if cross-talk …
View article: Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells
Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells Open
Humoral immunity depends on intrinsic B cell developmental programs guided by systemic signals that convey physiologic needs. Aberrant cues or their improper interpretation can lead to immune insufficiency or a failure of tolerance and aut…
View article: The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis
The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis Open
Responding to systemic demands in producing and replenishing end-effector blood cells is predicated on the appropriate delivery and interpretation of extrinsic signals to the HSPCs. The data presented herein implicate the systemic, extrace…
View article: 13. Functional Role of Adenovirus Penton in Modulating In Vivo Properties of Liver-Targeted and Liver-Detargeted Adenovirus Variants
13. Functional Role of Adenovirus Penton in Modulating In Vivo Properties of Liver-Targeted and Liver-Detargeted Adenovirus Variants Open
Pharmacokinetic studies of adenovirus (Ad) vectors after intravascular delivery demonstrate that the majority of an administered virus dose is rapidly sequestered from the circulation by the liver. The molecular determinants that target Ad…