Eric Fabian
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View article: Análises filogenéticas microbianas utilizando dados moleculares: uma revisão
Análises filogenéticas microbianas utilizando dados moleculares: uma revisão Open
A ideia de desenhar e esquematizar a evolução biológica por meio de árvores filogenéticas provavelmente teve como ponto de partida o desenvolvimento do sistema de classificação por Linnaeus, no século 18, dando origem a filogenia. O estudo…
View article: Effects of live yeast and starch supplementation on in vitro fermentation and methane production of tropical grass
Effects of live yeast and starch supplementation on in vitro fermentation and methane production of tropical grass Open
This study aimed to evaluate the effects of supplementation of live yeast (LY) associated with starch levels (SL) on the in vitro kinetic parameters of the gas production (GP), in vitro neutral detergent fiber digestibility (IVNDFD), volat…
View article: Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA)
Minimum information for reporting on the TEER (trans-epithelial/endothelial electrical resistance) assay (MIRTA) Open
Standard information reporting helps to ensure that assay conditions and data are consistently reported and to facilitate inter-laboratory comparisons. Here, we present recommendations on minimum information for reporting on the TEER (tran…
View article: Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment
Development and validation of PBPK models for genistein and daidzein for use in a next-generation risk assessment Open
Introduction All cosmetic ingredients must be evaluated for their safety to consumers. In the absence of in vivo data, systemic concentrations of ingredients can be predicted using Physiologically based Pharmacokinetic (PBPK) models. Howev…
View article: Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full‐thickness skin model
Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full‐thickness skin model Open
In a read‐across assessment of the safety of genistein and daidzein in cosmetic products, additional information was required to account for differences in their systemic exposure after topical application in a typical body lotion formulat…
View article: Characterization of the in vitro penetration and first‐pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full‐thickness skin models
Characterization of the in vitro penetration and first‐pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full‐thickness skin models Open
OECD test guideline compliant skin penetration studies, which also comply with the SCCS basic criteria, are lacking for genistein and daidzein. Therefore, we have measured their penetration and metabolism using ex vivo explants of fresh (i…
View article: Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion
Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion Open
Introduction: We performed an exposure-based Next Generation Risk Assessment case read-across study using New Approach Methodologies (NAMs) to determine the highest safe concentration of daidzein in a body lotion, based on its similarities…
View article: Toward Realistic Dosimetry <i>In Vitro</i>: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an <i>In Silico</i> Mass Balance Model
Toward Realistic Dosimetry <i>In Vitro</i>: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an <i>In Silico</i> Mass Balance Model Open
Nominal concentrations (CNom) in cell culture media are routinely used to define concentration–effect relationships in the in vitro toxicology. The actual concentration in the medium (CMedium) can be affected by adsorption processes, evapo…
View article: Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione
Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione Open
Methyl acrylate (MA) and ethyl acrylate (EA) had previously tested positive for mutagenicity in vitro, but in vivo studies were negative. One of the metabolism pathways of alkyl acrylates is conjugation with glutathione. The glutathione av…
View article: Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data Open
The goal of the present study was to assess the predictive performance of a generic human physiologically based kinetic (PBK) model based on in vitro and in silico input data and the effect of using different input approaches for chemical …
View article: Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on <i>In Vitro</i> and <i>In Silico</i> Input Data
Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on <i>In Vitro</i> and <i>In Silico</i> Input Data Open
The goal of the present study was to assess the predictive performance of a minimal generic rat physiologically based kinetic (PBK) model based on in vitro and in silico input data to predict peak plasma concentrations (Cmax) upon single o…
View article: Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat
Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat Open
View article: Cosmetics Europe evaluation of 6 in silico skin penetration models
Cosmetics Europe evaluation of 6 in silico skin penetration models Open
The ADME TF aims to develop in silico skin penetration models using in vitro human skin penetration data for 25 chemicals solubilized in wataer. Since there are widely differing opinions on different in silico models, we evaluated 3 open s…
View article: Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models Open
Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the impact of chain structure on skin and liver metabolism. Incubations with primary human hepatocyt…
View article: Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide
Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide Open
View article: Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol Open
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm 2 ) of chemicals was measured over 24 hours. The dermal delivery (DD)…
View article: Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models Open
The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the organism, is crucial for inhaled compounds entering this organ intentionally (e.g. drugs) and unintentionally (e.g. work place and environmental compoun…
View article: In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds
In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds Open
While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay concentrations may misrepresent potential in vivo effects and do not provide dose-response data which can be used for a risk assessment. We used revers…
View article: Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies
Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies Open
For regulatory purposes prenatal developmental toxicity (OECD No. 414) studies are routinely performed in our laboratories. The suitability of metabolomics as technology to identify maternal toxicity in such studies was investigated. Plasm…
View article: Correction to: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
Correction to: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Open
View article: Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Open
Studies on the metabolic fate of medical drugs, skin care products, cosmetics and other chemicals intentionally or accidently applied to the human skin have become increasingly important in order to ascertain pharmacological effectiveness …
View article: Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data
Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data Open
View article: Intrinsic Xenobiotic Metabolizing Enzyme Activities in Early Life Stages of Zebrafish (Danio rerio)
Intrinsic Xenobiotic Metabolizing Enzyme Activities in Early Life Stages of Zebrafish (Danio rerio) Open
Early life stages of zebrafish (Danio rerio, zf) are gaining attention as an alternative invivo test system for drug discovery, early developmental toxicity screenings and chemical testing in ecotoxicological and toxicological testing stra…
View article: Metabolomics as read-across tool: A case study with phenoxy herbicides
Metabolomics as read-across tool: A case study with phenoxy herbicides Open
New technologies, such as metabolomics, can address chemical grouping and read across from a biological perspective. In a virtual case study, we selected MCPP as target substance and MCPA and 2,4-DP as source substances with the goal to wa…
View article: Using in vitro/in silico data for consumer safety assessment of feed flavoring additives – A feasibility study using piperine
Using in vitro/in silico data for consumer safety assessment of feed flavoring additives – A feasibility study using piperine Open
Consumer health risk assessment for feed additives is based on the estimated human exposure to the additive that may occur in livestock edible tissues compared to its hazard. We present an approach using alternative methods for consumer he…
View article: Land Use/Land Cover Change Assessment of Dane County, Wisconsin : Contemporary Trend and Future Projections
Land Use/Land Cover Change Assessment of Dane County, Wisconsin : Contemporary Trend and Future Projections Open