Eric Eldering
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View article: Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms
Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms Open
The chemokine receptor CXCR4 is overexpressed in many cancers and contributes to pathogenesis, disease progression, and resistance to therapies. CXCR4 is known to form oligomers, but the potential functional relevance in malignancies remai…
CD40L and IL-4 suppress NK cell-mediated antibody-dependent cellular cytotoxicity through the HLA-E:NKG2A axis Open
Background Anti-CD20 antibodies are first-line treatments for B cell malignancies. Natural killer (NK) cells are important mediators of anti-CD20 antibody efficacy in humans through antibody-dependent cellular cytotoxicity (ADCC). In B cel…
View article: Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms
Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms Open
The chemokine receptor CXCR4 is overexpressed in many cancers and contributes to pathogenesis, disease progression, and resistance to therapies. CXCR4 is known to form oligomers, but the potential functional relevance in malignancies remai…
View article: T-cell dysfunction in CLL is mediated through expression of Siglec-10 ligands CD24 and CD52 on CLL cells
T-cell dysfunction in CLL is mediated through expression of Siglec-10 ligands CD24 and CD52 on CLL cells Open
Autologous T-cell–based therapies, such as chimeric antigen receptor (CAR) T-cell therapy, exhibit low success rates in chronic lymphocytic leukemia (CLL) and correlate with a dysfunctional T-cell phenotype observed in patients. Despite va…
Immunometabolism unveiled: Pioneering breakthroughs in cancer therapeutics Open
The field of immunometabolism cannot be considered ‘emerging’ anymore; it is at the moment one of the most active and rapidly evolving areas of biomedical research. Its hottest zone is cancer immunometabolism. This is partly due to the cli…
View article: Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies
Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies Open
The tumor suppressor p53 has been described to control various aspects of metabolic reprogramming in solid tumors, but in B cell malignancies that role is as yet unknown. We generated pairs of p53 functional and knockout (KO) clones from d…
View article: Metabolic reprogramming in the CLL TME; potential for new therapeutic targets
Metabolic reprogramming in the CLL TME; potential for new therapeutic targets Open
Chronic lymphocytic leukemia (CLL) cells circulate between peripheral (PB) blood and lymph node (LN) compartments, and strictly depend on microenvironmental factors for proliferation, survival and drug resistance. All cancer cells display …
Differential expression pattern of Bcl-2 family members in B and T cells in systemic lupus erythematosus and rheumatoid arthritis Open
Objective This study aimed to evaluate the expression level of anti-apoptotic Bcl-2 family proteins in B and T cells in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in relation to disease activity and the …
In Vitro 3D Spheroid Culture System Displays Sustained T Cell-dependent CLL Proliferation and Survival Open
Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironmental cells and signals. The lymph node (LN) is the critical site of in vivo CLL proliferation and development of resistance to both chemotherapy and targeted ag…
View article: T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia
T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia Open
Acquired T-cell dysfunction is common in chronic B-cell malignancies. Given the strong connection between T-cell metabolism and function, we investigated metabolic alterations as the basis of T-cell dysfunction induced by malignant cells. …
S140: IBRUTINIB SENSITIZES CLL CELLS TO VENETOCLAX BY INTERRUPTING TLR9-INDUCED CD40 UPREGULATION AND PROTEIN TRANSLATION Open
Topic: 5. Chronic lymphocytic leukemia and related disorders - Biology & Translational Research Background: Chronic lymphocytic leukemia (CLL) cells upregulate Bcl-2 proteins within the lymph node (LN) microenvironment. Signaling via B-cel…
View article: P595: DEFECTIVE MITOCHONDRIAL METABOLISM IS AT THE BASIS OF T-CELL DYSFUNCTION IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
P595: DEFECTIVE MITOCHONDRIAL METABOLISM IS AT THE BASIS OF T-CELL DYSFUNCTION IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS Open
Background: Chronic lymphocytic leukemia (CLL) remains incurable despite availability of targeted therapies. Successful autologous cell-based anti-cancer therapies require functionality and longevity of effector cells, features that highly…
View article: P593: T-CELL DYSFUNCTION BY PSEUDOHYPOXIA AND AUTOCRINE PURINERGIC SIGNALING IN CHRONIC LYMPHOCYTIC LEUKEMIA
P593: T-CELL DYSFUNCTION BY PSEUDOHYPOXIA AND AUTOCRINE PURINERGIC SIGNALING IN CHRONIC LYMPHOCYTIC LEUKEMIA Open
Background: Acquired T-cell dysfunction is a prominent feature in chronic B-cell malignancies, such as chronic lymphocytic leukemia (CLL). This is widely assumed to hinder the efficacy of T-cell based immunotherapy. T cells rely on metabol…
View article: Electron transport chain and mTOR inhibition synergistically decrease CD40 signaling and counteract venetoclax resistance in chronic lymphocytic leukemia
Electron transport chain and mTOR inhibition synergistically decrease CD40 signaling and counteract venetoclax resistance in chronic lymphocytic leukemia Open
CD40 signaling upregulates BCL-XL and MCL-1 expression in the chronic lymphocytic leukemia (CLL) lymph node microenvironment (TME), affording resistance to the BCL-2 inhibitor venetoclax (VEN). VEN resistance in the therapeutic setting and…
<i>In vitro</i>lymph node-mimicking 3D model displays long-term T cell-dependent CLL proliferation and survival Open
Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironmental cells and signals. The lymph node (LN) is the critical site of in vivo CLL proliferation and development of resistance to both chemotherapy and targeted ag…
Data from Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas Open
T-cell redirecting bispecific antibodies hold high promise for treatment of B-cell malignancies. B-cell maturation antigen (BCMA) exhibits high expression on normal and malignant mature B cells including plasma cells, which can be enhanced…
Supplementary Tables 1-3, Figures 1-4 from Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas Open
Supplementary Table 1. CLL Patient characteristics. Supplementary Table 2. Healthy donor characteristics. Supplementary Table 3. MM patient characteristics. Supplementary Figure 1. γ-secretase inhibition increases BCMA levels but does not …
Data from Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas Open
T-cell redirecting bispecific antibodies hold high promise for treatment of B-cell malignancies. B-cell maturation antigen (BCMA) exhibits high expression on normal and malignant mature B cells including plasma cells, which can be enhanced…
Supplementary Tables 1-3, Figures 1-4 from Redirecting T-cell Activity with Anti-BCMA/Anti-CD3 Bispecific Antibodies in Chronic Lymphocytic Leukemia and Other B-cell Lymphomas Open
Supplementary Table 1. CLL Patient characteristics. Supplementary Table 2. Healthy donor characteristics. Supplementary Table 3. MM patient characteristics. Supplementary Figure 1. γ-secretase inhibition increases BCMA levels but does not …
Ectopic expression of cGAS in <i>Salmonella typhimurium</i> enhances STING-mediated IFN-β response in human macrophages and dendritic cells Open
Background Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with …
View article: Supplementary Figure 1 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 1 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 986K, A. ABT-737 resistant CLL cells were stimulated with CD40L for 72 hours (n=4). The black line shows apoptosis levels from CLL cells detached from the feeder layer and subsequently treated with different concentrations of AB…
View article: Supplementary Figure 2 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 2 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 620K, CLL cells were stimulated with CD40L for the indicated time (24, 48 and 72 hrs). Western blots of Bfl-1 were quantified with Odyssey software in both ABT-737 sensitive (n=4) and ABT-737 resistant (n=4) CD40-stimulated CLL …
View article: Data from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Data from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
Purpose: Chronic lymphocytic leukemia (CLL) cells in lymph nodes (LN), from which relapses are postulated to originate, display an antiapoptotic profile in contrast to CLL cells from peripheral blood (PB). The BH3 mimetic ABT-737 antagoniz…
View article: Supplementary Figure 1 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 1 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 986K, A. ABT-737 resistant CLL cells were stimulated with CD40L for 72 hours (n=4). The black line shows apoptosis levels from CLL cells detached from the feeder layer and subsequently treated with different concentrations of AB…
View article: Supplementary Figure 3 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 3 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 793K, Nucleofection with Noxa siRNA or control siRNA was performed on CLL cells in the presence or absence of the proteasoom inhibitor GSI. Protein lysates were probed for Mcl-1, Noxa and �-actin. As a control, lysates of untran…
View article: Supplementary Figure 5 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 5 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 866K, CLL cells were stimulated with CD40L for 48 hrs. After detachment, cells were incubated with 10 �M or 100 �M fludarabine � Q-VD (12,5 �M), � NAC (5mM). Protein lysates were probed for Noxa, Mcl-1 and �-actin.
View article: Supplementary Figure 5 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia
Supplementary Figure 5 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia Open
PDF file - 866K, CLL cells were stimulated with CD40L for 48 hrs. After detachment, cells were incubated with 10 �M or 100 �M fludarabine � Q-VD (12,5 �M), � NAC (5mM). Protein lysates were probed for Noxa, Mcl-1 and �-actin.