C. Eric Elmquist
YOU?
Author Swipe
View article: Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA
Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA Open
Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. Among many forms of…
View article: DNA Sequence Modulates the Conformation of the Food Mutagen 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline in the Recognition Sequence of the <i>Nar</i>I Restriction Enzyme<sup>,</sup>
DNA Sequence Modulates the Conformation of the Food Mutagen 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline in the Recognition Sequence of the <i>Nar</i>I Restriction Enzyme<sup>,</sup> Open
The conformations of C8-dG adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) positioned in the C-X1-G, G-X2-C, and C-X3-C contexts in the C-G1-G2-C-G3-C-C recognition sequence of the NarI restriction enzyme were compared, using the o…
View article: Conformational Differences of the C8-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ) within the <i>Nar</i>I Recognition Sequence
Conformational Differences of the C8-Deoxyguanosine Adduct of 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ) within the <i>Nar</i>I Recognition Sequence Open
2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is a highly mutagenic heterocyclic amine found in cooked meats. The major DNA adduct of IQ is at the C8-position of dGuo. We have previously reported the incorporation of the C8-IQ adduct into o…
View article: Base-Displaced Intercalated Structure of the Food Mutagen 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline in the Recognition Sequence of the <i>Nar</i>I Restriction Enzyme, a Hotspot for −2 bp Deletions
Base-Displaced Intercalated Structure of the Food Mutagen 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline in the Recognition Sequence of the <i>Nar</i>I Restriction Enzyme, a Hotspot for −2 bp Deletions Open
The solution structure of the oligodeoxynucleotide 5'-d(CTCGGCXCCATC)-3'.5'-d(GATGGCGCCGAG)-3' containing the heterocyclic amine 8-[(3-methyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-2'-deoxyguanosine adduct (IQ) at the third guanine in the N…