Explanipedia

Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study Open

Sten de Schrijver, Emiel Vanhulle, Anne Ingenbleek, Leonidas Alexakis, Caroline Klint Johannesen , et al. · 2025

Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023. Methods Aggregated data were …

Outcomes of Enterococcus faecalis infective endocarditis according to MIC of amoxicillin: a multicentric study Open

Hermann Do Rego, Yousra Kherabi, Stéphane Corvec, Chloé Plouzeau-Jayle, Coralie Bouchiat , et al. · 2024

Background The incidence of Enterococcus faecalis infective endocarditis is increasing over time. Data on the impact of minimum inhibitory concentration (MIC) of amoxicillin on treatment outcomes are scarce. The objective of this study was…

Effectiveness of temocillin in treatment of non-urinary tract infections caused by ESBL-producing Enterobacterales and risk factors for failure Open

Christel Mamona Kilu, Camille Menvielle, Aldo Cataldi, Antoine Hamon, Clara Duran , et al. · 2024

Objectives To describe the real-life use of temocillin for non-urinary tract infections, to assess its effectiveness in infections caused by ESBL-producing Enterobacterales, and to identify risk factors for treatment failure. Method Retros…

Oligella spp.: A systematic review on an uncommon urinary pathogen Open

Éric Farfour, Marc Vasse, Alexandre Vallée · 2024

Background Oligella is an uncommon Gram-negative coccobacillus that was first thought to belong to the urogenital tract. The genus Oligella comprises two species that were recovered from various samples worldwide. Methods We perform a syst…

Can Haematological Parameters Discriminate COVID-19 from Influenza? Open

Sahar Gnaba, Dmitry Sukhachev, Tiffany Pascreau, Félix Ackermann, Frédérique Delcominette , et al. · 2023

Symptoms of COVID-19 are similar to the influenza virus, but because treatments and prognoses are different, it is important to accurately and rapidly differentiate these diseases. The aim of this study was to evaluate whether the analysis…

Impact of revised breakpoints on the categorization of susceptibility of Enterobacterales to temocillin Open

Éric Farfour, Cécile Le Brun, Nicolas Degand, Emeline Riverain, Aurélien Dinh , et al. · 2023

Background To harmonize with the EUCAST breakpoints, the French Society of Microbiology introduced a change in the inhibition diameter breakpoint (17 mm versus 20 mm previously) of temocillin. We assessed the impact of the new breakpoints …

Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open

Camille Roquencourt, Hélène Salvator, Emmanuelle Bardin, Elodie Lamy, Éric Farfour , et al. · 2023

Background Although rapid screening for and diagnosis of coronavirus disease 2019 (COVID-19) are still urgently needed, most current testing methods are long, costly or poorly specific. The objective of the present study was to determine w…

Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19 Open

Camille Roquencourt, Hélène Salvator, Emmanuelle Bardin, Elodie Lamy, Éric Farfour , et al. · 2023

Background Although rapid screening for and diagnosis of COVID-19 are still urgently needed, most current testing methods are either long, costly, and/or poorly specific. The objective of the present study was to determine whether or not a…

Impact of COVID-19 pandemic on blood culture practices and bacteremia epidemiology Open

Éric Farfour, Valentin Clichet, Gauthier Péan de Ponfilly, Étienne Carbonnelle, Marc Vasse · 2023

Rarely Encountered Gram-Negative Rods and Lung Transplant Recipients: A Narrative Review Open

Éric Farfour, Antoine Roux, Édouard Sage, Hélène Revillet, Marc Vasse , et al. · 2023

The respiratory tract of lung transplant recipients (LTR) is likely to be colonized with non-fermentative Gram-negative rods. As a consequence of the improvements in molecular sequencing and taxonomy, an increasing number of bacterial spec…

Inquilinus limosus Bacteremia in Lung Transplant Recipient after SARS-CoV-2 Infection Open

Éric Farfour, M. Zrounba, Antoine Roux, Hélène Revillet, Alexandre Vallée , et al. · 2023

Inquilinus limosus is an environmental bacterium associated with respiratory tract colonization in cystic fibrosis patients. We report a case of I. limosus bacteremia in a patient in France who received a lung transplant and experienced ch…

Stratification of COVID-19 Severity Using SeptiCyte RAPID, a Novel Host Immune Response Test Open

Victor Gravrand, François Mellot, Félix Ackermann, Marie‐Christine Ballester, Benjamin Zuber , et al. · 2023

SeptiCyte® RAPID is a gene expression assay measuring the relative expression levels of host response genes PLA2G7 and PLAC8, indicative of a dysregulated immune response during sepsis. As severe forms of COVID-19 may be considered viral s…

Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales Open

Agnès B. Jousset, Sandrine Bernabeu, Cécile Emeraud, Rémy A. Bonnin, A. Lomont , et al. · 2023

Overall, C/T showed good activity against wild-type Enterobacterales, AmpC producers, and ESBL-producing Escherichia coli but is less active against ESBL-producing Klebsiella pneumoniae, and CRE. E-test® led to an underestimation of the MI…

Prognostic value of cellular population data in patients with COVID-19 Open

Marc Vasse, Dmitry Sukhachev, Marie‐Christine Ballester, Frédérique Delcominette, François Mellot , et al. · 2023

SARS-CoV-2 viability and viral RNA persistence on microbiological agar plates Open

Éric Farfour, S. Lebourgeois, Houssem Redha Chenane, C. Charpentier, T. Pascreau , et al. · 2022

Temporal dynamics of RSV shedding and genetic diversity in adults during the COVID-19 pandemic in a French hospital, early 2021 Open

Romain Coppée, Houssem Redha Chenane, Antoine Bridier‐Nahmias, Colas Tchérakian, Émilie Catherinot , et al. · 2022

Human respiratory syncytial virus (RSV) is responsible of lower respiratory tract infections which may be severe in infants, elderly and immunocompromised adults. Europe and North-American countries have observed a massive reduction of RSV…

Stratification of COVID-19 severity using SeptiCyte RAPID, a novel host immune response test Open

Victor Gravrand, François Mellot, Félix Ackermann, Marie‐Christine Ballester, Benjamin Zuber , et al. · 2022

SeptiCyte ® RAPID is a gene expression assay measuring the relative expression levels of host response genes PLA2G7 and PLAC8, indicative of a dysregulated immune response during sepsis. As severe forms of COVID-19 may be considered viral …

Discrimination of Escherichia coli, Shigella flexneri, and Shigella sonnei using lipid profiling by MALDI‐TOF mass spectrometry paired with machine learning Open

Jade Pizzato, Wenhao Tang, Sandrine Bernabeu, Rémy A. Bonnin, Emmanuelle Bille , et al. · 2022

Matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry (MALDI‐TOF MS) has become a staple in clinical microbiology laboratories. Protein‐profiling of bacteria using this technique has accelerated the identification of…

Impact of COVID-19 on Subclinical Placental Thrombosis and Maternal Thrombotic Factors Open

Marie Carbonnel, Camille Daclin, Morgan Tourne, Emmanuel Roux, Mathilde Le-Marchand , et al. · 2022

Background: In the context of the SARS-CoV-2 pandemic, our interest was to evaluate the effect of COVID-19 during pregnancy on placenta and coagulation factors. Methods: a prospective cohort study between January and July 2021 of 55 pregna…

Evaluation of Four Fully Integrated Molecular Assays for the Detection of Respiratory Viruses during the Co-Circulation of SARS-CoV-2, Influenza and RSV Open

Éric Farfour, Thomas Yung, Robin Baudoin, Marc Vasse · 2022

Background: The clinical presentation of viral respiratory infections is unspecific. We assessed the performances of two new RT-PCR, the Idylla™ SARS-CoV-2 and the Idylla™ SARS-CoV2/Flu/RSV, and two isothermal amplification assays, the ID …

Monkeypox virus: A novel sexually transmitted disease? A case report from France Open

Alexandre Vallée, Éric Farfour, David Zucman · 2022

Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France Open

Éric Farfour, Laurent Dortet, Thomas Guillard, N. Chatelain, Agathe Poisson , et al. · 2022

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered fro…

COVID-19 reinfection after pregnancy Open

L Gobin, Alexandre Vallée, David Zucman, Marie Carbonnel, J. Laperrelle , et al. · 2022

Trend in Respiratory Viruses’ Activity in the COVID-19 Area Open

Éric Farfour, Lamia Rouabah, Pauline Bargain, Marion Lecuru, Stuti Gera Denis-Petit , et al. · 2022

An Immunogenicity Report for the Comparison between Heterologous and Homologous Prime-Boost Schedules with ChAdOx1-S and BNT162b2 Vaccines Open

Alexandre Vallée, Marc Vasse, Laurence Mazaux, Brigitte Bonan, C Amiel , et al. · 2021

Background: There is a small amount of immunological data on COVID-19 heterologous vaccination schedules in humans. We assessed the immunogenicity of BNT162b2 (Pfizer/BioNTech) administered as a second dose in healthcare workers primed wit…

P–793 Validation of French in vitro fertilization (IVF) guideline during Covid–19 pandemic by the research of Sars-Cov–2 RNA in the follicular fluid (FF) after egg retrieval Open

Camille Fossard, Éric Farfour, Achraf Benammar, Meryem Filali, Jessica Vandame , et al. · 2021

Study question Is it possible to find viral Sars-Cov–2 RNA in FF of women undergoing treatment during Covid–19 pandemic that may compromise gamete and embryo safety? Summary answer No viral RNA was detected in tested FF of women undergoing…

The high frequency of anti-PF4/heparin antibodies in patients with COVID-19 is neither related to heparin treatment or to an increased incidence of thrombosis Open

Tiffany Pascreau, Marie‐Christine Ballester, Patrick Van Dreden, Sara Zia-Chahabi, Benjamin Zuber , et al. · 2021

Article The high frequency of anti-PF4/heparin antibodies in patients with COVID-19 is neither related to heparin treatment or to an increased incidence of thrombosis was published on October 1, 2021 in the journal Clinical Chemistry and L…

Trends in asymptomatic STI among HIV-positive MSM and lessons for systematic screening Open

Éric Farfour, Svetlane Dimi, Olivier Chassany, S. Fouéré, Nadia Valin , et al. · 2021

The burden of STIs is particularly high in HIV-infected MSM patients. A recent increase in STIs prevalence has been noticed in the US and western European countries. We aim to assess trends in asymptomatic STIs following the publication of…

Validation of the French IVF guidelines during the COVID-19 pandemic Open

Marine Poulain, Camille Fossard, Achraf Benammar, Éric Farfour, S. D. U. M. Ranga , et al. · 2021

A high blood endocan profile during COVID-19 distinguishes moderate from severe acute respiratory distress syndrome Open

Tiffany Pascreau, Colas Tchérakian, Benjamin Zuber, Éric Farfour, Marc Vasse , et al. · 2021

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