Eric Fujimura
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View article: Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses
Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses Open
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping…
View article: Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1 Open
Significance The PD-1/PD-L1 immunoinhibitory axis plays a key role in immune evasion of cancer cells, and therapies targeting PD-1/PD-L1 show high efficacy in certain cancer types. Understanding how cancer drivers regulate immune surveilla…
View article: Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality Open
SARS-CoV-2 (CoV2) antibody therapies, including COVID-19 convalescent plasma (CCP), monoclonal antibodies, and hyperimmune globulin, are among the leading treatments for individuals with early COVID-19 infection. The functionality of conva…
View article: Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality Open
COVID-19 convalescent plasma, particularly plasma with high-titer SARS-CoV-2 (CoV2) antibodies, has been successfully used for treatment of COVID-19. The functionality of convalescent plasma varies greatly, but the association of antibody …
View article: Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity Open
Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infe…