Eric G. Sheu
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View article: How does AI compare to the experts in a Delphi setting: simulating medical consensus with large language models
How does AI compare to the experts in a Delphi setting: simulating medical consensus with large language models Open
Background: Several attempts have been made to enhance decision-making capabilities of large language models (LLMs) through debate and collaboration, simulating human-like deliberative processes. However, limited research exists on whether…
View article: Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease
Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease Open
Aim Metabolic bariatric surgery (MBS) improves histological endpoints in steatotic liver disease (SLD), but data on longer‐term clinical outcomes in this population are scarce. Here, we assessed the impact of MBS on hepatic and extrahepati…
View article: Evaluating National Trends in Bleeding Associated with Metabolic Bariatric Surgery over 7 Years
Evaluating National Trends in Bleeding Associated with Metabolic Bariatric Surgery over 7 Years Open
Background Post-operative bleeding is a known complication after metabolic bariatric surgery (MBS). This study evaluates the national trends in the rates of bleeding, factors associated with bleeding, and impact of bleeding complication on…
View article: Alterations in glucocorticoid homeostasis following sleeve gastrectomy
Alterations in glucocorticoid homeostasis following sleeve gastrectomy Open
Elevated intra-tissue levels of active glucocorticoids in obese patients are associated with insulin resistance, diabetes, impaired immune regulation, and other adverse effects. Sleeve gastrectomy (SG) induces significant weight loss and i…
View article: FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity Open
Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated diseases. However, there are no scalable approaches to comprehensively assess the diverse FFAs circulating in human plasma. Furthermore, a…
View article: FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity Open
Summary Cellular exposure to free fatty acids (FFA) is implicated in the pathogenesis of obesity-associated diseases. However, studies to date have assumed that a few select FFAs are representative of broad structural categories, and there…
View article: Sleeve gastrectomy promotes colitis-associated colorectal cancer in a murine model via a modified gut microbiome
Sleeve gastrectomy promotes colitis-associated colorectal cancer in a murine model via a modified gut microbiome Open
Colorectal cancer (CRC) remains the third leading cause of cancer death in the United States with an alarming rise among young (<50-years-old) patients. 1 Epidemiologically, obesity appears to be a risk factor for CRC. 1 Although bariatric…
View article: Low density, high impact? Neutrophil changes in obesity and bariatric surgery
Low density, high impact? Neutrophil changes in obesity and bariatric surgery Open
The worldwide obesity pandemic continues to worsen, with an estimated 650 million adults with obesity according to the World Health Organization's most recent 2016 estimate.1 While the morbidity of metabolic diseases, such as type 2 diabet…
View article: Early Changes in Immune Cell Count, Metabolism, and Function Following Sleeve Gastrectomy: A Prospective Human Study
Early Changes in Immune Cell Count, Metabolism, and Function Following Sleeve Gastrectomy: A Prospective Human Study Open
Objective To characterize longitudinal changes in blood biomarkers, leukocyte composition, and gene expression following laparoscopic sleeve gastrectomy (LSG). Background LSG is an effective treatment for obesity, leading to sustainable we…
View article: Restored TDCA and valine levels imitate the effects of bariatric surgery
Restored TDCA and valine levels imitate the effects of bariatric surgery Open
Background: Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. Methods: Metabolic profilin…
View article: Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery
Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery Open
Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. We performed sleeve-gastrectomies (SGx)…
View article: Lipid metabolism_ primers.xlsx
Lipid metabolism_ primers.xlsx Open
Supplementary Table 1. Forward and reverse quantitative polymerase chain reaction (qPCR) primers for measuring relative expression levels of genes involved in fatty acid uptake (CD36, FABP2, FATP1, FATP4) and fatty acid β-oxidation (CPT1A,…
View article: Lo_Human_Sleeve_SuppTable01.xlsx
Lo_Human_Sleeve_SuppTable01.xlsx Open
Supplementary Table 1. A set of 337 transcripts that demonstrated a significant change in whole blood gene expression in six subjects three months after laparoscopic sleeve gastrectomy compared to the baseline pre-operative state (false di…
View article: Lo_Human_Sleeve_SuppTable02.xlsx
Lo_Human_Sleeve_SuppTable02.xlsx Open
Supplementary Table 2. Forward and reverse quantitative polymerase chain reaction (qPCR) primers for measuring the expression of six candidate genes of interest (ID1, IFNE, IGF2, MMP15, PDPK2P, SLCO2A1) related to surgical weight loss. Ubi…
View article: Early changes in immune cell metabolism and function are a hallmark of sleeve gastrectomy: a prospective human study
Early changes in immune cell metabolism and function are a hallmark of sleeve gastrectomy: a prospective human study Open
Objective To characterize longitudinal changes in blood biomarkers, leukocyte composition, and gene expression following laparoscopic sleeve gastrectomy (LSG). Background LSG is an effective treatment for obesity, leading to sustainable we…
View article: Weight and organ specific immune cell profiling of Sleeve Gastrectomy
Weight and organ specific immune cell profiling of Sleeve Gastrectomy Open
Sleeve gastrectomy (SG) has profound, immediate weight-loss independent effects on obesity related diabetes (T2D). Our prior studies have shown that immunologic remodeling may play a part in this metabolic improvement. However, to date, li…
View article: Sleeve gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss
Sleeve gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss Open
Sleeve gastrectomy (SG) induces weight loss-independent improvements in glucose homeostasis by unknown mechanisms. We sought to identify the metabolic adaptations responsible for these improvements. Nonobese C57BL/6J mice on standard chow …
View article: Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects
Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects Open
Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is consistently associated with increased levels of the incretin hormone GLP-1 and changes in overall levels of circulating bile acids. The levels of individu…
View article: Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss
Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss Open
Objective Sleeve gastrectomy (SG) induces weight-loss independent improvements in glucose homeostasis by unknown mechanisms. We sought to identify the metabolic adaptations responsible for these improvements. Methods Non-obese C57Bl6/J mic…