Eric G. Sun
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View article: Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification
Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification Open
In mammalian cells, gene copy number is controlled to maintain gene expression and genome stability. However, a common molecular feature across cancer types is oncogene amplification, increasing the copy number and expression of tumor-prom…
View article: Engineered extrachromosomal oncogene amplifications promote tumorigenesis
Engineered extrachromosomal oncogene amplifications promote tumorigenesis Open
Focal gene amplifications are among the most common cancer-associated mutations1 but have proven challenging to engineer in primary cells and model organisms. Here we describe a general strategy to engineer large (more than 1 Mbp) focal am…