Explanipedia

GDF15 mediates inflammation-associated bone loss through a brain-bone axis 4055 Open

Dirk Elewaut, Renee Vandercruyssen, Ján Deván, Peggy Jacques, Stefan Dudli , et al. · 2025

Description Metabolic mediators play an important role in regulating chronic inflammation in the body. Here we report an unexpected role for GDF15 (Growth Differentiation Factor 15), a central mediator of food intake, in inflammation-assoc…

SUN-145 Effects of Progestogen Supplementation in Feminizing Hormone Therapy: A Mouse Model of Adolescent Gender Transition Open

Salvatore Blanco, Oriana Nobus, Toke Liekens, Lieve Verlinden, Ingrid Stockmans , et al. · 2025

Disclosure: S. Calvo Blanco: None. O. Nobus: None. T. Liekens: None. L. Verlinden: None. I. Stockmans: None. K. Moermans: None. F. Stappers: None. L. Crombez: None. C. Vercruysse: None. K. Van Belleghem: None. S. Lamon: None. E. Gracey: No…

A cell atlas of human and mouse synovium from early and advanced stages of knee osteoarthritis: BHLHE40 regulates fibroblast activation Open

Kabriya Thavaratnam, Eric Gracey, A. Ratneswaran, Jason S. Rockel, Shabana Vohra , et al. · 2025

Osteoarthritis (OA) is a destructive joint disease affecting multiple tissues, including synovium. Previous studies have identified some distinct fibroblast subtypes within synovium; however, the characterization of fibroblast subsets duri…

AI-driven histologic analysis of human Achilles tendinopathy provides a roadmap to unravel pathogenesis Open

Guillaume Planckaert, Arne Burssens, Flore Stappers, Julie Coudenys, Sofía Demolder , et al. · 2025

Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis Open

Hayley Peters, Pratibha Potla, Jason S. Rockel, Teodora Tockovska, Chiara Pastrello , et al. · 2024

Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis Open

Hayley Peters, Pratibha Potla, Jason S. Rockel, Teodora Tockovska, Chiara Pastrello , et al. · 2024

Objectives In this study, we employ a multi-omic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine differences in the IFP based on knee osteoarthri…

GDF15 mediates inflammation-associated bone loss through a brain-bone axis Open

Dirk Elewaut, Renée Van der Cruyssen, Ján Deván, Irina Heggli, Dominik Bürri , et al. · 2024

Metabolic mediators play an important role in regulating inflammation(1). Rheumatoid arthritis and spondyloarthritis are common inflammatory diseases of the joint, aggravated in context of obesity(2). These patients experience systemic bon…

GDF15 mediates inflammation-associated bone loss through a brain-bone axis Open

Renée Van der Cruyssen, Ján Deván, Irina Heggli, Dominik Bürri, Djoere Gaublomme , et al. · 2023

SUMMARY Metabolic mediators play an important role in regulating chronic inflammation in the body. Here we report an unexpected role for GDF15 (Growth Differentiation Factor 15), a central mediator of food intake, in inflammation-associate…

Sterile triggers drive joint inflammation in TNF‐ and IL ‐1β‐dependent mouse arthritis models Open

Alexandra Thiran, Ιωάννα Πέττα, Gillian Blancke, Marie Thorp, Guillaume Planckaert , et al. · 2023

Sterile triggers drive joint inflammation in TNF and IL-1β dependent mouse arthritis models Open

Alexandra Thiran, Ιωάννα Πέττα, Gillian Blancke, Marie Thorp, Guillaume Plankaert , et al. · 2023

Arthritis is the most common extra-intestinal complication in inflammatory bowel disease (IBD). Conversely, arthritis patients are at risk for developing IBD and often display subclinical gut inflammation. These observations suggest a shar…

RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells Open

Céline Mortier, Eric Gracey, Julie Coudenys, Teddy Manuello, Tine Decruy , et al. · 2023

Objective Divergent therapeutic outcomes on different disease domains have been noted with IL-23 and IL-17A-blockade in PsA. Therefore, elucidating the role of RORγt, the master regulator of type 17 immune responses, is of potential therap…

Cell Behavior Changes and Enzymatic Biodegradation of Hybrid Electrospun Poly(3‐hydroxybutyrate)‐Based Scaffolds with an Enhanced Piezoresponse after the Addition of Reduced Graphene Oxide Open

Roman V. Chernozem, Igor O. Pariy, Maria A. Surmeneva, Vladimir V. Shvartsman, Guillaume Planckaert , et al. · 2022

This is the first comprehensive study of the impact of biodegradation on the structure, surface potential, mechanical and piezoelectric properties of poly(3‐hydroxybutyrate) (PHB) scaffolds supplemented with reduced graphene oxide (rGO) as…

From Science to Success? Targeting Tyrosine Kinase 2 in Spondyloarthritis and Related Chronic Inflammatory Diseases Open

Dominika Hromadová, Dirk Elewaut, Robert D. Inman, Birgit Strobl, Eric Gracey · 2021

Spondyloarthritis (SpA) is a family of inflammatory arthritic diseases, which includes the prototypes of psoriatic arthritis and ankylosing spondylitis. SpA is commonly associated with systemic inflammatory diseases, such as psoriasis and …

Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints Open

Zuzanna Łukasik, Eric Gracey, Koen Venken, Christopher T. Ritchlin, Dirk Elewaut · 2021

Several lines of evidence point towards the central role of IL-23 as a crucial inflammatory mediator in the pathogenesis of SpA—a group of inflammatory arthritic diseases whose symptoms span the skin, gastrointestinal tract and joints. Whi…

GEF-H1 Is Required for Colchicine Inhibition of Neutrophil Rolling and Recruitment in Mouse Models of Gout Open

Noah Fine, Eric Gracey, Ioannis D. Dimitriou, José La Rose, Michael Glogauer , et al. · 2020

Gout is a painful arthritic inflammatory disease caused by buildup of monosodium urate (MSU) crystals in the joints. Colchicine, a microtubule-depolymerizing agent that is used in prophylaxis and treatment of acute gout flare, alleviates t…

Publisher Correction: Revisiting the gut–joint axis: links between gut inflammation and spondyloarthritis Open

Eric Gracey, Lars Vereecke, Dermot McGovern, Mareike Fröhling, Georg Schett , et al. · 2020

TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis Open

Eric Gracey, Dominika Hromadová, Melissa Lim, Zoya Qaiyum, Michael Zeng , et al. · 2020

Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and peripheral joints. Ankylosing spondylitis (AS) is the prototypic form of SpA in which progressive disease can lead to fusion of the spine. Therapeuticall…

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis Open

Eric Gracey, Arne Burssens, Isabelle Cambré, Georg Schett, Rik Lories , et al. · 2020

Response to: ‘Gut-derived CD8+ tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients’ by Guggino et al Open

Zoya Qaiyum, Eric Gracey, Yuchen Yao, Robert D. Inman · 2019

Erratum: CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima Open

Mark Roufaiel, Eric Gracey, Allan Siu, Su-Ning Zhu, Andrew Lau , et al. · 2017

Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis Open

Eric Gracey, Zoya Qaiyum, John Kuruvilla, Robert D. Inman · 2016

To the Editor: Tumor necrosis factor inhibitors (TNFi) are widely used for the treatment of ankylosing spondylitis (AS), with infliximab (IFX) being approved by the US Food and Drug Administration for AS in 2004. Adverse event rates remain…

IL-10 Production Is Critical for Sustaining the Expansion of CD5+ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice Open

Yuriy Baglaenko, Kieran Manion, Nan‐Hua Chang, Eric Gracey, Christina Loh , et al. · 2016

The development and progression of systemic lupus erythematosus is mediated by the complex interaction of genetic and environmental factors. To decipher the genetics that contribute to pathogenesis and the production of pathogenic autoanti…

Pulmonary Chlamydia muridarum challenge activates lung interstitial macrophages which correlate with IFN‐γ production and infection control in mice Open

Eric Gracey, Yuriy Baglaenko, Nadia Prayitno, Nico van Rooijen, Ali Akram , et al. · 2015

Protective immunity to the pathogen Chlamydia is dependent on a robust IFN‐γ response generated by innate and adaptive lymphocytes. Here we assess the role of the macrophage in orchestrating a protective response in vivo to the murine path…

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