Eric Hanssen
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View article: Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium
Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium Open
Sulfate-reducing bacteria import organosulfur compounds from the environment for anaerobic respiration. They contribute to human disease and are problematic in industrial settings because they produce hydrogen sulfide. Here, we demonstrate…
View article: The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily
The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily Open
Cell surface molecules play fundamental roles in cell-cell communication, attraction, or repulsion, and when expressed in neurons they are often implicated in neurological disorders. FAM171 is a family of three type-I transmembrane domain …
View article: Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes
Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes Open
The Type IX Secretion System exports proteins across the outer membrane (OM) of bacteria in the Bacteroidota phylum, however, the mechanistic details remain unknown. In Porphyromonas gingivalis the core components of the multi-protein comp…
View article: Plasmonic Color Filters Enable Label-Free Plasmon-Enhanced Array Tomography with sub-diffraction limited resolution
Plasmonic Color Filters Enable Label-Free Plasmon-Enhanced Array Tomography with sub-diffraction limited resolution Open
Three-dimensional (3D) imaging of the subcellular organisation and morphology of cells and tissues is essential for understanding biological function. Although staining is the most widely used approach for visualising biological samples un…
View article: Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta
Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta Open
Summary Mitochondria adapt their structure through fusion and fission, yet how their morphology and cristae architecture alter as cells differentiate remains unclear. The human placenta is an ideal model for studying mitochondrial diversit…
View article: Structural basis for the pore-forming activity of a complement-like toxin
Structural basis for the pore-forming activity of a complement-like toxin Open
Pore-forming proteins comprise a highly diverse group of proteins exemplified by the membrane attack complex/perforin (MACPF), cholesterol-dependent cytolysin (CDC), and gasdermin superfamilies, which all form gigantic pores (>150 angstrom…
View article: Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system
Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system Open
The Type IX Secretion System exports proteins across the outer membrane (OM) of bacteria in the Bacteroidota phylum, however, the mechanistic details remain unknown. Here, we present a ∼3.5Å cryo-EM structure of the periplasmic rings compr…
View article: Montage electron cryo-tomography with square and rectangular beams.
Montage electron cryo-tomography with square and rectangular beams. Open
View article: Adaptations of <i>Escherichia coli</i> K 12 to Synchrotron Sourced THz Radiation
Adaptations of <i>Escherichia coli</i> K 12 to Synchrotron Sourced THz Radiation Open
The biological effects of electromagnetic field (EMF) irradiation in the terahertz (THz) range remain ambiguous, despite numerous studies that have been conducted. In this paper, the metabolic response of Escherichia coli K 12 to EM…
View article: Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers Open
View article: Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice
Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice Open
The immune response against Legionella longbeachae, a causative agent of the often-fatal Legionnaires' pneumonia, is poorly understood. Here, we investigated the specific roles of tissue-resident alveolar macrophages (AMs) and infiltrating…
View article: Opposing roles of resident and infiltrating immune cells in the defence against<i>Legionella longbeachae</i>via IL-18R/IFN-γ/ROS axis
Opposing roles of resident and infiltrating immune cells in the defence against<i>Legionella longbeachae</i>via IL-18R/IFN-γ/ROS axis Open
The immune response against Legionella longbeachae , a causative agent of the often-fatal Legionnaires’ pneumonia, is poorly understood. Here we investigated the specific roles of tissue-resident alveolar macrophages (AM) and infiltrating …
View article: The Arteria Lymphatica and Lymphatic Microperforators: A Dedicated Blood Supply to Collecting Lymphatics and Their Potential Implications in Lymphedema: Anatomical Description
The Arteria Lymphatica and Lymphatic Microperforators: A Dedicated Blood Supply to Collecting Lymphatics and Their Potential Implications in Lymphedema: Anatomical Description Open
Background: Lymphedema is common after lymphatic damage in cancer treatment, with negative impacts on function and quality of life. Evidence suggests that blood vessel microvasculature is sensitive to irradiation and trauma; however, despi…
View article: The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains
The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains Open
ATP-binding cassette (ABC) transporters are ubiquitous membrane proteins responsible for the translocation of a wide diversity of substrates across biological membranes. Some of them confer multidrug or antimicrobial resistance to cancer c…
View article: Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant Open
View article: Fitting a square beam in a square camera: Novel condenser apertures for low-dose transmission electron microscopy
Fitting a square beam in a square camera: Novel condenser apertures for low-dose transmission electron microscopy Open
In transmission electron microscopy (TEM), cameras are square or rectangular but beams are round so the circular lobes irradiate adjacent areas, precluding further neighboring acquisition for beam sensitive samples. We present condenser ap…
View article: Fitting a square beam in a square camera: novel condenser apertures for low-dose transmission electron microscopy
Fitting a square beam in a square camera: novel condenser apertures for low-dose transmission electron microscopy Open
In transmission electron microscopy (TEM) cameras are square or rectangular but beams are round. With a beam size chosen to fill the camera at a given image magnification, the circular lobes of the beam will extend beyond the camera’s fiel…
View article: The effect of calcium removal from skim milk by ion exchange on the properties of the ultrafiltration retentate
The effect of calcium removal from skim milk by ion exchange on the properties of the ultrafiltration retentate Open
New processes are needed to produce concentrated milk feedstocks with tailored calcium content, due to the direct link between calcium concentration and final product texture and functionality. Skim milk treatment with cation exchange resi…
View article: Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease
Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease Open
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for …
View article: Modeling human skeletal development using human pluripotent stem cells
Modeling human skeletal development using human pluripotent stem cells Open
Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will provide insights into skeletal development and genetic skeletal disorders and will generate cells for regenerative medicine applications. Here, we…
View article: Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner Open
View article: Functionalized Gold Nanoclusters Promote Stress Response in COS‐7 Cells
Functionalized Gold Nanoclusters Promote Stress Response in COS‐7 Cells Open
Nanotoxicity Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to their unique optical and physicochemical properties. The associated nanotoxicology concerns need to be carefully considered because …
View article: Functionalized Gold Nanoclusters Promote Stress Response in COS‐7 Cells
Functionalized Gold Nanoclusters Promote Stress Response in COS‐7 Cells Open
Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to their unique optical and physicochemical properties; however, the associated nanotoxicology concerns need to be carefully considered because of t…
View article: CardioVinci: building blocks for virtual cardiac cells using deep learning
CardioVinci: building blocks for virtual cardiac cells using deep learning Open
Advances in electron microscopy (EM) such as electron tomography and focused ion-beam scanning electron microscopy provide unprecedented, three-dimensional views of cardiac ultrastructures within sample volumes ranging from hundreds of nan…
View article: Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy: an <i>in silico</i> study
Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy: an <i>in silico</i> study Open
Diabetic cardiomyopathy is a leading cause of heart failure in diabetes. At the cellular level, diabetic cardiomyopathy leads to altered mitochondrial energy metabolism and cardiomyocyte ultrastructure. We combined electron microscopy (EM)…
View article: Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes
Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes Open
View article: MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy
MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy Open
View article: Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant
Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant Open
Summary Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in numerous autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling…
View article: Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy – an in-silico study
Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy – an in-silico study Open
Summary Diabetic cardiomyopathy is a leading cause of heart failure in diabetes. At the cellular level, diabetic cardiomyopathy leads to altered mitochondrial energy metabolism and cardiomyocyte ultrastructure. We combined electron microsc…
View article: Extracellular Vesicles Secreted by Glioma Stem Cells Are Involved in Radiation Resistance and Glioma Progression
Extracellular Vesicles Secreted by Glioma Stem Cells Are Involved in Radiation Resistance and Glioma Progression Open
Glioblastoma is the most aggressive brain tumour with short survival, partly due to resistance to conventional therapy. Glioma stem cells (GSC) are likely to be involved in treatment resistance, by releasing extracellular vesicles (EVs) co…