Eric Hillpot
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View article: Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair
Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair Open
Aging is marked by the accumulation of senescent cells (SnCs), which contribute to tissue dysfunction and age-related diseases. Senotherapeutics, including senolytics which specifically induce lysis of SnCs and senomorphics, which suppress…
View article: SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice
SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice Open
SIRT6 is a protein deacylase, deacetylase, and mono-ADP-ribosylase (mADPr) regulating biological pathways important for longevity including DNA repair and silencing of LINE1 retrotransposons. SIRT6 knockout mice die by 30 days of age, wher…
View article: cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation Open
Aging-associated inflammation, or ‘inflammaging” is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the cytop…
Evolution of High-Molecular-Mass Hyaluronic Acid is Associated with Subterranean Lifestyle Open
Hyaluronic acid (HA) is a major component of extracellular matrix (ECM) which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (NMR, Heterocephalus glaber …
View article: DNA repair and anti-cancer mechanisms in the long-lived bowhead whale
DNA repair and anti-cancer mechanisms in the long-lived bowhead whale Open
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg 1 . Despite its very large number of cells and long lifespan, t…
Susceptibility of epithelial cells cultured from different regions of human cervix to HPV16-induced immortalization Open
Persistent infection with high-risk human papillomavirus (HPV) is a major risk factor for cervical cancer. Greater than 90% of these cancers originate in the cervical transformation zone (TZ), a narrow region of metaplastic squamous epithe…