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View article: Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop
Piezo1 activation suppresses bone marrow adipogenesis to prevent osteoporosis by inhibiting a mechanoinflammatory autocrine loop Open
With aging or osteoporosis, bone marrow adipogenesis is increased and inversely correlates with the loss of bone mass. Bone marrow adipocytes are derived from multipotent bone marrow mesenchymal stem cells (BMMSCs), which can differentiate…
View article: Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development
Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development Open
BACKGROUND: Pulmonary hypertension (PH) is a life-threatening and progressive yet incurable disease. The hallmarks of PH comprise (1) sustained contraction and (2) excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs).…
View article: Role of the mechano-sensitive ion channel Piezo1 in the regulation of the metabolism of the thermogenic brown adipocytes
Role of the mechano-sensitive ion channel Piezo1 in the regulation of the metabolism of the thermogenic brown adipocytes Open
International audience
View article: Role of the mechano-sensitive ion channel Piezo1 in the regulation of the thermogenic functions of brown adipocytes
Role of the mechano-sensitive ion channel Piezo1 in the regulation of the thermogenic functions of brown adipocytes Open
International audience
View article: Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion
Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion Open
An inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by…
View article: A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes
A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes Open
The molecular transducers conferring the benefits of chronic exercise in diabetes prevention remain to be comprehensively investigated. Herein, serum proteomic profiling of 688 inflammatory and metabolic biomarkers in 36 medication-naive o…
View article: Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects
Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects Open
Thyroid hormone (TH) is a thermogenic activator with anti-obesity potential. However, systemic TH administration has no obvious clinical benefits on weight reduction. Herein we selectively delivered triiodothyronine (T3) to adipose tissues…
View article: Pharmacological activation of PIEZO1 in human red blood cells prevents <i>Plasmodium falciparum</i> invasion
Pharmacological activation of PIEZO1 in human red blood cells prevents <i>Plasmodium falciparum</i> invasion Open
An inherited gain-of–function variant (E756 del) in the mechanosensitive cationic channel PIEZO1 was recently shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) in…
View article: Structure and function of polycystins: insights into polycystic kidney disease
Structure and function of polycystins: insights into polycystic kidney disease Open
International audience
View article: Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection
Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection Open
Hereditary xerocytosis (HX) is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. Gain-of-function (GOF) mutations in mechanosensitive Piezo1 ion channels are identified in HX pati…