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View article: Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network Open
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted a…
View article: The Role of Cadherin 17 (CDH17) in Cancer Progression via Wnt/β-Catenin Signalling Pathway: A Systematic Review and Meta-Analysis
The Role of Cadherin 17 (CDH17) in Cancer Progression via Wnt/β-Catenin Signalling Pathway: A Systematic Review and Meta-Analysis Open
Cadherin 17 (CDH17) is a cell adhesion glycoprotein essential for epithelial integrity. It is frequently overexpressed in various cancers, where it is associated with aggressive behaviour. While evidence indicates that CDH17 functions as a…
View article: Weight loss interventions and obesity‐associated cancers in people with type 2 diabetes and overweight/obesity: A real‐world observational study
Weight loss interventions and obesity‐associated cancers in people with type 2 diabetes and overweight/obesity: A real‐world observational study Open
Aims To evaluate whether weight‐loss interventions are associated with obesity‐associated cancers (OAC) in individuals with overweight/obesity and type 2 diabetes (T2D). Materials and Methods This retrospective cohort study utilised the Tr…
View article: Precision Prevention Studies: A Targeted Approach to Cancer Prevention
Precision Prevention Studies: A Targeted Approach to Cancer Prevention Open
Precision prevention trials are biologically driven interception studies conducted in high cancer risk groups. These are smaller, potentially faster, cheaper, and more commercially attractive than traditional large-scale population prevent…
View article: Relationship between household air pollution and lung cancer in never smokers in high-income countries: a systematic review
Relationship between household air pollution and lung cancer in never smokers in high-income countries: a systematic review Open
Objectives Lung cancer is increasingly being diagnosed in non-smokers, with mounting evidence that household air pollution is a potential factor. Environmental risk factors for lung cancer in never-smokers (LCINS) in relation to combustion…
View article: Review of Network Meta-Analyses on the Efficacy of Chemopreventive Agents on Colorectal Adenomas and Cancer
Review of Network Meta-Analyses on the Efficacy of Chemopreventive Agents on Colorectal Adenomas and Cancer Open
Background Colorectal cancer (CRC) is the third most diagnosed cancer and the second leading cause of cancer-related death worldwide. Colorectal adenomas (CRAs) are a crucial precursor for CRC and a target for preventive strategies. Recent…
View article: Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision
Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision Open
Background Hereditary adenomatous polyposis syndromes, including familial adenomatous polyposis and other rare adenomatous polyposis syndromes, increase the lifetime risk of colorectal and other cancers. Methods A team of 38 experts conven…
View article: Redox modulation of oxidatively-induced DNA damage by ascorbate enhances both in vitro and ex-vivo DNA damage formation and cell death in melanoma cells
Redox modulation of oxidatively-induced DNA damage by ascorbate enhances both in vitro and ex-vivo DNA damage formation and cell death in melanoma cells Open
Elevated genomic instability in cancer cells suggests a possible model-scenario for their selective killing via the therapeutic delivery of well-defined levels of further DNA damage. To examine this scenario, this study investigated the po…
View article: Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities
Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities Open
Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with high-q…
View article: Duration of type 2 diabetes and incidence of cancer: an observational study in England
Duration of type 2 diabetes and incidence of cancer: an observational study in England Open
ObjectiveTo investigate the association between duration of type 2 diabetes and cancer incidence.Research Design and MethodsIn the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥3…
View article: Duration of type 2 diabetes and incidence of cancer: an observational study in England
Duration of type 2 diabetes and incidence of cancer: an observational study in England Open
ObjectiveTo investigate the association between duration of type 2 diabetes and cancer incidence.Research Design and MethodsIn the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥3…
View article: A transmission chain linking<i>Mycobacterium ulcerans</i>with<i>Aedes notoscriptus</i>mosquitoes, possums and human Buruli ulcer cases in southeastern Australia
A transmission chain linking<i>Mycobacterium ulcerans</i>with<i>Aedes notoscriptus</i>mosquitoes, possums and human Buruli ulcer cases in southeastern Australia Open
In temperate southeastern Australia over the past two decades there has been a marked progressive increase in human cases of Buruli ulcer, an infection of subcutaneous tissue caused by Mycobacterium ulcerans . Native possums are the major …
View article: Supplementary Table 2 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Supplementary Table 2 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
Supplementary Table 2 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
View article: Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention Open
Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
View article: Data from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
Data from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention Open
Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich standardized bilberry extract, causes pharmacodynamic changes consistent with ch…
View article: Supplementary Tables 1-5, Methods from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Supplementary Tables 1-5, Methods from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
Supplementary Tables 1-5, Methods from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
View article: Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
View article: Data from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Data from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
In view of safety concerns surrounding the use of pharmaceuticals such as nonsteroidal anti-inflammatory drugs and tamoxifen as cancer chemopreventive agents, potentially innocuous phytochemicals derived from the diet are considered attrac…
View article: Figure S2 from <i>EGFR</i> and <i>MET</i> Amplifications Determine Response to HER2 Inhibition in <i>ERBB2</i>-Amplified Esophagogastric Cancer
Figure S2 from <i>EGFR</i> and <i>MET</i> Amplifications Determine Response to HER2 Inhibition in <i>ERBB2</i>-Amplified Esophagogastric Cancer Open
CONSORT diagram
View article: Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention Open
Perspective on this Article from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
View article: Data from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Data from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
In view of safety concerns surrounding the use of pharmaceuticals such as nonsteroidal anti-inflammatory drugs and tamoxifen as cancer chemopreventive agents, potentially innocuous phytochemicals derived from the diet are considered attrac…
View article: Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials Open
Supplementary Figure 1 from Development of Dietary Phytochemical Chemopreventive Agents: Biomarkers and Choice of Dose for Early Clinical Trials
View article: Data from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention
Data from Pilot Study of Oral Anthocyanins for Colorectal Cancer Chemoprevention Open
Naturally occurring anthocyanins possess colorectal cancer chemopreventive properties in rodent models. We investigated whether mirtocyan, an anthocyanin-rich standardized bilberry extract, causes pharmacodynamic changes consistent with ch…