Éric Konofal
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View article: La narcolepsie et ses traitements au siècle de Gélineau : sa contribution et son héritage
La narcolepsie et ses traitements au siècle de Gélineau : sa contribution et son héritage Open
View article: From past to future: 50 years of pharmacological interventions to treat narcolepsy
From past to future: 50 years of pharmacological interventions to treat narcolepsy Open
The history of narcolepsy research began with the pioneering work of Jean-Baptiste-Édouard Gélineau in the late 19th century. In the 1880s, Gélineau introduced the term "narcolepsy" to describe a condition characterized by sudden and uncon…
View article: 0585 A four-week randomized, double-blind, placebo-controlled, phase 2 study of mazindol ER in the treatment of narcolepsy
0585 A four-week randomized, double-blind, placebo-controlled, phase 2 study of mazindol ER in the treatment of narcolepsy Open
Introduction Mazindol is the first partial orexin 2 receptor agonist and triple monoamine reuptake inhibitor in development for the treatment of narcolepsy. A novel extended release (ER) formulation was developed to allow once-daily dosing…
View article: 0578 Clinician and Patient Global Impression in a Phase 2 Study of Mazindol (NLS-1021) in Adults with Narcolepsy Type 1 and Type 2
0578 Clinician and Patient Global Impression in a Phase 2 Study of Mazindol (NLS-1021) in Adults with Narcolepsy Type 1 and Type 2 Open
Introduction Mazindol is the first partial orexin 2 receptor agonist and triple monoamine reuptake inhibitor in development for the treatment of narcolepsy. Clinician and Patient Global Impression (CGI and PGI, respectively) for cataplexy …
View article: 0593 Functional Outcomes of Sleep Questionnaire in a phase 2 study of mazindol ER in narcolepsy
0593 Functional Outcomes of Sleep Questionnaire in a phase 2 study of mazindol ER in narcolepsy Open
Introduction Efficacy secondary outcome measure Functional Outcomes of Sleep Questionnaire, Short Version (FOSQ-10] was collected in the Phase 2 (POLARIS, NLS-1021), multicenter (n=21) study of mazindol ER in adult participants with narcol…
View article: 0595 Long-term efficacy on cataplexy attacks and excessive daytime sleepiness in open-label extension study (NLS-1022) of mazindol ER
0595 Long-term efficacy on cataplexy attacks and excessive daytime sleepiness in open-label extension study (NLS-1022) of mazindol ER Open
Introduction Mazindol ER (extended-release), the first partial orexin-2 receptor agonist and triple mono-aminergic reuptake inhibitor, has demonstrated efficacy and safety in significantly reducing excessive daytime sleepiness (EDS) and ca…
View article: 0025 Effects of NLS-4 (Lauflumide) and modafinil in a rat model of circadian rhythm and chronic severe fatigue
0025 Effects of NLS-4 (Lauflumide) and modafinil in a rat model of circadian rhythm and chronic severe fatigue Open
Introduction The chronic fatigue syndrome (CFS) is a heterogeneous disorder characterized by easy fatigability, feverishness, diffuse pains, and depression. Many COVID-19 patients expressed a long-term effect of coronavirus (long-COVID), w…
View article: NLS-3 (Levophacetoperane or (R,R) Phacetoperane): A Reverse Esterof Methylphenidate: A Literature Review
NLS-3 (Levophacetoperane or (R,R) Phacetoperane): A Reverse Esterof Methylphenidate: A Literature Review Open
Background: NLS-3 or (R, R) enantiomer of phacetoperane (levophacetoperane) is the reverse ester of methylphenidate, a well-documented psychostimulant marketed for the treatment of attention-deficit/hyperactivity disorder (ADHD) since the …
View article: Adjustment to lockdown in children and adolescents with narcolepsy in France
Adjustment to lockdown in children and adolescents with narcolepsy in France Open
View article: ADHD management during the COVID-19 pandemic: guidance from the European ADHD Guidelines Group
ADHD management during the COVID-19 pandemic: guidance from the European ADHD Guidelines Group Open
Contains fulltext : 220663.pdf (Publisher’s version ) (Open Access)
View article: Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome
Cross-sectional study of loop gain abnormalities in childhood obstructive sleep apnea syndrome Open
View article: The utility of acoustic pharyngometry and rhinometry in pediatric obstructive sleep apnea syndrome
The utility of acoustic pharyngometry and rhinometry in pediatric obstructive sleep apnea syndrome Open
View article: Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound
Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound Open
Psychostimulants are used for the treatment of excessive daytime sleepiness in a wide range of sleep disorders as well as in attention deficit hyperactivity disorder or cognitive impairment in neuropsychiatric disorders. Here, we tested in…
View article: A Double-Blind, Placebo-Controlled, Phase II Study to Determine the Efficacy, Safety, Tolerability and Pharmacokinetics of a Controlled Release (CR) Formulation of Mazindol in Adults with DSM-5 Attention-Deficit/Hyperactivity Disorder (ADHD)
A Double-Blind, Placebo-Controlled, Phase II Study to Determine the Efficacy, Safety, Tolerability and Pharmacokinetics of a Controlled Release (CR) Formulation of Mazindol in Adults with DSM-5 Attention-Deficit/Hyperactivity Disorder (ADHD) Open
View article: Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder
Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder Open
Background Behavioural interventions are recommended for use with children and young people with attention deficit hyperactivity disorder ( ADHD ); however, specific guidance for their implementation based on the best available evidence is…
View article: The European ADHD Guidelines Group replies:
The European ADHD Guidelines Group replies: Open
View article: Neurofeedback for Attention-Deficit/Hyperactivity Disorder: Meta-Analysis of Clinical and Neuropsychological Outcomes From Randomized Controlled Trials
Neurofeedback for Attention-Deficit/Hyperactivity Disorder: Meta-Analysis of Clinical and Neuropsychological Outcomes From Randomized Controlled Trials Open
View article: Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Pediatric Narcolepsy: A Cross-Sectional Study
Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Pediatric Narcolepsy: A Cross-Sectional Study Open
Pediatric patients with narcolepsy have high levels of treatment-resistant attention-deficit/hyperactivity disorder (ADHD) symptoms. The optimal treatment for ADHD symptoms in these patients warrants further evaluation in longitudinal inte…