Eric L. Bittman
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View article: Neuroendocrine effects of the duper mutation in Syrian hamsters: a role for Cryptochrome 1
Neuroendocrine effects of the duper mutation in Syrian hamsters: a role for Cryptochrome 1 Open
Molecular and physiological determinants of the timing of reproductive events, including the pre-ovulatory LH surge and seasonal fluctuations in fertility, are incompletely understood. We used the Cryptochrome 1 -deficient duper mutant to …
View article: Adult Neurogenesis Is Altered by Circadian Phase Shifts and the Duper Mutation in Female Syrian Hamsters
Adult Neurogenesis Is Altered by Circadian Phase Shifts and the Duper Mutation in Female Syrian Hamsters Open
Cell birth and survival in the adult hippocampus are regulated by a circadian clock. Rotating shift work and jet lag disrupt circadian rhythms and aggravate disease. Internal misalignment, a state in which abnormal phase relationships prev…
View article: The duper mutation reveals previously unsuspected functions of <i>Cryptochrome 1</i> in circadian entrainment and heart disease
The duper mutation reveals previously unsuspected functions of <i>Cryptochrome 1</i> in circadian entrainment and heart disease Open
The Cryptochrome 1 ( Cry1 )–deficient duper mutant hamster has a short free-running period in constant darkness (τ DD ) and shows large phase shifts in response to brief light pulses. We tested whether this measure of the lability of the c…
View article: <i>duper</i>is a null mutation of Cryptochrome 1 in Syrian hamsters
<i>duper</i>is a null mutation of Cryptochrome 1 in Syrian hamsters Open
Significance We successfully identified the duper allele as a null mutation of Cryptochrome 1 in Syrian hamsters. Here, we have shown the use of fast homozygosity mapping as an effective approach to identify causal mutations in mammals, de…
View article: Entrainment data Duper vs WT.xlsx
Entrainment data Duper vs WT.xlsx Open
Entrainment data collected from syrian hamsters.
View article: Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge
Circadian Function in Multiple Cell Types Is Necessary for Proper Timing of the Preovulatory LH Surge Open
The timing of the preovulatory surge of luteinizing hormone (LH), which occurs on the evening of proestrus in female mice, is determined by the circadian system. The identity of cells that control the phase of the LH surge is unclear: evid…