Eric Larsen
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View article: Factors associated with central nervous system relapse after b-acute lymphoblastic leukemia: A Children's oncology group report
Factors associated with central nervous system relapse after b-acute lymphoblastic leukemia: A Children's oncology group report Open
Introduction: While advancements in treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL), through incorporation of novel agents such as blinatumomab, have resulted in remarkable improvements in disease-free survival (Gupta, N…
View article: Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B
Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B Open
Summary Polymorphisms that affect chr21 gene expression have significance for both variable severity in Down syndrome and common multifactorial conditions. Results here demonstrate “selective homolog silencing” in cells from even one indiv…
View article: 32 | METABOLIC‐ONLY RESPONSE ASSESSMENT ALLOWS RADIATION OMISSION FOR MAJORITY WITH CLASSICAL HODGKIN LYMPHOMA AND MAINTAINS EXCELLENT OUTCOMES: A PHC PHASE 2 STUDY cHOD17
32 | METABOLIC‐ONLY RESPONSE ASSESSMENT ALLOWS RADIATION OMISSION FOR MAJORITY WITH CLASSICAL HODGKIN LYMPHOMA AND MAINTAINS EXCELLENT OUTCOMES: A PHC PHASE 2 STUDY cHOD17 Open
View article: Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia
Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia Open
PURPOSE Although cure rates for childhood acute lymphoblastic leukemia (ALL) exceed 90%, ALL remains a leading cause of cancer death in children. Half of relapses arise in children initially classified with standard-risk (SR) disease. MATE…
View article: Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children’s Oncology Group Report
Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children’s Oncology Group Report Open
Current strategies to treat pediatric acute lymphoblastic leukemia rely on risk stratification algorithms using categorical data. We investigated whether using continuous variables assigned different weights would improve risk stratificati…
View article: Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232
Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232 Open
View article: Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group
Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group Open
PURPOSE Patients with Down syndrome (DS) and B-ALL experience increased rates of relapse, toxicity, and death. We report results for patients with DS B-ALL enrolled on Children's Oncology Group trials between 2003 and 2019. METHODS We anal…
View article: Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children
Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children Open
View article: Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials
Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children's Oncology Group cohort trials Open
View article: Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia Open
Importance Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Hepatotoxic effects, including hyperbilirubinemia and elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, are common during…
View article: Sex‐based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group report
Sex‐based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group report Open
Background Boys with acute lymphoblastic leukemia (ALL) have historically experienced inferior survival compared to girls. This study determined whether sex‐based disparities persist with contemporary therapy and whether patterns of treatm…
View article: <i>Notes from the Field:</i> Outbreak of COVID-19 Among a Highly Vaccinated Population Aboard a U.S. Navy Ship After a Port Visit — Reykjavik, Iceland, July 2021
<i>Notes from the Field:</i> Outbreak of COVID-19 Among a Highly Vaccinated Population Aboard a U.S. Navy Ship After a Port Visit — Reykjavik, Iceland, July 2021 Open
View article: ZNF146/OZF and ZNF507 target LINE-1 sequences
ZNF146/OZF and ZNF507 target LINE-1 sequences Open
Repetitive sequences including transposable elements and transposon-derived fragments account for nearly half of the human genome. While transposition-competent transposable elements must be repressed to maintain genomic stability, mutated…
View article: Perceived Efficacy, Reduced Prescription Drug Use, and Minimal Side Effects of Cannabis in Patients with Chronic Orthopedic Pain
Perceived Efficacy, Reduced Prescription Drug Use, and Minimal Side Effects of Cannabis in Patients with Chronic Orthopedic Pain Open
Introduction: Although cannabis is widely used for the treatment of chronic pain, most research relies on patient self-report and few studies have objectively quantified its efficacy and side effects. Extant inventories for measurin…
View article: Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children’s Oncology Group Study AALL0232
Outcomes in adolescent and young adult patients (16 to 30 years) compared to younger patients treated for high-risk B-lymphoblastic leukemia: report from Children’s Oncology Group Study AALL0232 Open
View article: ZNF146/OZF and ZNF507 target LINE-1 sequences
ZNF146/OZF and ZNF507 target LINE-1 sequences Open
Repetitive sequences including transposable elements (TEs) and transposon-derived fragments account for nearly half of the human genome. While transposition-competent TEs must be repressed to maintain genomic stability, mutated and fragmen…
View article: Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation
Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation Open
PURPOSE Brentuximab vedotin, an effective anti-CD30 antibody-drug conjugate approved for use in adults with classical Hodgkin lymphoma (HL), was introduced in this frontline trial to reduce prescribed radiation in children and adolescents …
View article: Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity
Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity Open
We conducted the first human leukocyte antigen (HLA) allele and genome‐wide association study to identify loci associated with hypersensitivity reactions exclusively to the PEGylated preparation of asparaginase (pegaspargase) in racially d…
View article: Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group Open
Purpose To characterize academic and adaptive skill outcomes in survivors of high‐risk B‐lineage acute lymphoblastic leukemia (HR B‐ALL). Methods Participants were 178 patients enrolled on a nontherapeutic clinical trial that aimed to char…
View article: Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia
Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia Open
Adolescents and young adults (AYAs) with acute lymphoblastic leukemia have improved outcomes when treated with pediatric-inspired regimens. CALGB 10403 was the largest prospective study to evaluate the feasibility of using a pediatric regi…
View article: Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations
Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations Open
View article: Association of<i>GATA3</i>Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia
Association of<i>GATA3</i>Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia Open
Background Minimal residual disease (MRD) after induction therapy is one of the strongest prognostic factors in childhood acute lymphoblastic leukemia (ALL), and MRD-directed treatment intensification improves survival. Little is known abo…
View article: Impact of Intrathecal Triple Therapy Versus Intrathecal Methotrexate on Disease-Free Survival for High-Risk B-Lymphoblastic Leukemia: Children’s Oncology Group Study AALL1131
Impact of Intrathecal Triple Therapy Versus Intrathecal Methotrexate on Disease-Free Survival for High-Risk B-Lymphoblastic Leukemia: Children’s Oncology Group Study AALL1131 Open
PURPOSE The high-risk stratum of Children’s Oncology Group Study AALL1131 was designed to test the hypothesis that postinduction CNS prophylaxis with intrathecal triple therapy (ITT) including methotrexate, hydrocortisone, and cytarabine w…
View article: Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group
Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group Open
PURPOSE Asparaginase (ASNase) is an important component of acute lymphoblastic leukemia (ALL) treatment, but is often discontinued because of toxicity. Erwinia chrysanthemi ASNase ( Erwinia) substitution was approved in 2011 for allergic r…
View article: HLA Haplotype DRB1*07:01-DQA1*02:01-DQB1*02:02 Predicts Pegaspargase Hypersensitivity
HLA Haplotype DRB1*07:01-DQA1*02:01-DQB1*02:02 Predicts Pegaspargase Hypersensitivity Open
View article: Excellent Outcome for Pediatric Patients with High Risk Hodgkin Lymphoma with Brentuximab Vedotin and Risk Adapted Residual Node Radiation
Excellent Outcome for Pediatric Patients with High Risk Hodgkin Lymphoma with Brentuximab Vedotin and Risk Adapted Residual Node Radiation Open
View article: Masked hypodiploidy: Hypodiploid acute lymphoblastic leukemia (ALL) mimicking hyperdiploid ALL in children: A report from the Children's Oncology Group
Masked hypodiploidy: Hypodiploid acute lymphoblastic leukemia (ALL) mimicking hyperdiploid ALL in children: A report from the Children's Oncology Group Open
View article: P766 Slings and arrows of syphilis surveillance: the department of defense experience with administrative case finding
P766 Slings and arrows of syphilis surveillance: the department of defense experience with administrative case finding Open
Background Routine surveillance of Military Health System (MHS) data provides actionable information on STI rates. National increases in syphilis rates led to the publication of a 2015 MHS syphilis analysis demonstrating a significant rise…
View article: Impact of corticosteroid pretreatment in pediatric patients with newly diagnosed B-lymphoblastic leukemia: a report from the Children’s Oncology Group
Impact of corticosteroid pretreatment in pediatric patients with newly diagnosed B-lymphoblastic leukemia: a report from the Children’s Oncology Group Open
View article: No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy
No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy Open
Background/Objectives Anthracyclines are used in induction therapy of pediatric acute lymphoblastic leukemia (ALL) and are known to generate oxidative stress; whether this translates into enhanced antileukemic activity or hemolytic effects…