Eric M. Chapman
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View article: Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes
Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes Open
The purpose of this study was to determine important genes, functions, and networks contributing to the pathobiology of cerebral cavernous malformation (CCM) from transcriptomic analyses across 3 species and 2 disease genotypes. Sequencing…
View article: Elucidating the Mechanism by which KRI-1/CCM1 Regulates Apoptosis Cell Non-Autonomously in Caenorhabditis elegans
Elucidating the Mechanism by which KRI-1/CCM1 Regulates Apoptosis Cell Non-Autonomously in Caenorhabditis elegans Open
Programmed cell death initiated by genotoxic stress requires signalling from surrounding tissues, yet such mechanisms are poorly understood. The C. elegans germline is a powerful model to study cell non-autonomous regulation of apoptosis, …
View article: Interrogating the ccm-3 Gene Network
Interrogating the ccm-3 Gene Network Open
Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1-3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans …