Jun Li
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View article: Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation
Multimodal mechanisms of di (2-ethylhexyl) phthalate-induced cardiovascular-kidney-metabolic syndrome: Integrating epidemiology, network toxicology and experimental validation Open
DEHP exposure promotes CKM syndrome through coordinated disruption of metabolic (PPARG), inflammatory (PTGS2), and fibrotic (MMP2) pathways, with obesity serving as a critical effect modifier. The integrated computational and experimental …
View article: Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study
Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study Open
BACKGROUND Refractory gastroesophageal reflux disease (GERD) constitutes a significant proportion of GERD cases and presents a considerable burden in clinical practice. However, the underlying risk factors contributing to persistent and re…
View article: Low and uneven rural road lighting coverage in Africa
Low and uneven rural road lighting coverage in Africa Open
Africa’s rapid urbanization and infrastructure expansion are driving demand for road lighting across the continent. However, the current knowledge regarding road lighting coverage is fragmented. Here, we employed high-resolution nighttime …
View article: CT-based emphysema score is associated with prolonged air leak after lung resection: a retrospective cohort study
CT-based emphysema score is associated with prolonged air leak after lung resection: a retrospective cohort study Open
CT-based emphysema score is associated with PAL following lung cancer resection and may help guide intraoperative planning and patient counseling.
View article: Stiefel MD Anderson OroPharynx cancer (MDA-OPC) cohort: a single-institution, prospective longitudinal outcomes study
Stiefel MD Anderson OroPharynx cancer (MDA-OPC) cohort: a single-institution, prospective longitudinal outcomes study Open
Purpose The MD Anderson Oropharynx Cancer (MDA-OPC) cohort is a unique single-institution, prospective longitudinal cancer cohort. The cohort aims to enhance the therapeutic index of OPC management by supporting data needs for independent …
View article: Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance
Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance Open
Bacillus Calmette‐Guérin (BCG) immunotherapy is limited by resistance in ∼50% of patients, linked to tumor microenvironment (TME) angiogenesis. The work explored if BCG‐activated tumor‐associated macrophages (TAMs) drive angiogenesis via h…
View article: Primary breast diffuse large B-cell lymphoma (germinal center B-cell-like subtype): a case report and literature review
Primary breast diffuse large B-cell lymphoma (germinal center B-cell-like subtype): a case report and literature review Open
Background Primary breast lymphoma (PBL) is a rare type of extranodal lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype. Due to its nonspecific clinical and imaging features, PBL is frequently…
View article: An Energy-Efficient Multi-Objective Optimization Framework for QoS-Aware Resource Allocation in 5G Slicing Networks
An Energy-Efficient Multi-Objective Optimization Framework for QoS-Aware Resource Allocation in 5G Slicing Networks Open
This paper investigates decision optimization for wireless resource allocation and energy-efficient scheduling in multi-user, multi-task 5G network slicing scenarios. We propose a hybrid computational framework combining particle swarm opt…
View article: Epidemiology, drug resistance, and clinical risk factors of peritoneal dialysis-associated peritonitis: a five-year multicenter study
Epidemiology, drug resistance, and clinical risk factors of peritoneal dialysis-associated peritonitis: a five-year multicenter study Open
Background Peritoneal dialysis-associated peritonitis (PDAP) remains a major complication in long-term dialysis patients, leading to significant morbidity and healthcare burden. This study aimed to investigate the microbial spectrum, antim…
View article: High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics
High-concentration L-methionine as a potent antioxidant for oxidation resistance and stability enhancement in high-concentration antibody therapeutics Open
The development of high-concentration monoclonal antibody (mAb) formulations for subcutaneous administration is faces critical stability challenges, particularly oxidation and aggregation, which compromise efficacy and safety. While antiox…
View article: MurreNet: Modeling Holistic Multimodal Interactions Between Histopathology and Genomic Profiles for Survival Prediction
MurreNet: Modeling Holistic Multimodal Interactions Between Histopathology and Genomic Profiles for Survival Prediction Open
Cancer survival prediction requires integrating pathological Whole Slide Images (WSIs) and genomic profiles, a challenging task due to the inherent heterogeneity and the complexity of modeling both inter- and intra-modality interactions. C…
View article: Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble
Preoperative prediction of major adverse outcomes after total arch replacement in acute type A aortic dissection based on machine learning ensemble Open
A machine learning model was developed and validated to predict postoperative complications in patients with acute type A aortic dissection (ATAAD) who underwent total arch replacement combined with frozen elephant trunk (TAR + FET), with …
View article: Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance
Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance Open
Breast cancer is the most common malignancy among women worldwide, with drug therapy playing a crucial role in its treatment. In recent years, poly ADP-ribose polymerase (PARP) inhibitors, such as Olaparib, have shown significant efficacy …
View article: Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment
Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment Open
Pancreatic cancer remains one of the most lethal malignancies in the digestive system, with limited available drugs and a need for improved efficacy. This unmet clinical need highlights the urgency to discover novel, highly efficient small…
View article: Hemodialysis pathway types influence wound healing complications and survival in end-stage renal disease patients in a retrospective cohort study
Hemodialysis pathway types influence wound healing complications and survival in end-stage renal disease patients in a retrospective cohort study Open
This study evaluates the impact of different hemodialysis access types—central venous catheter (CVC), arteriovenous graft (AVG), and autologous arteriovenous fistula (AVF)—on wound healing, complication rates, and long-term survival in pat…
View article: Exploratory Algorithms to Aid in Risk of Malignancy Prediction for Indeterminate Pulmonary Nodules
Exploratory Algorithms to Aid in Risk of Malignancy Prediction for Indeterminate Pulmonary Nodules Open
Background/Objectives: Lung cancer screening can reduce patient mortality. Multiple issues persist including timely management of patients with a radiologically defined indeterminate pulmonary nodule (IPN), which carries unknown pathologic…
View article: Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024
Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024 Open
Background Herpes zoster severely impacts patients’ quality of life and therapeutic results. This research utilized data from the FDA Adverse Event Reporting System (FAERS) to examine the prevalence and attributes of drug-induced herpes zo…
View article: AI-Driven Drug Discovery for Breast Cancer Based on ERBB2 Identified Through Network Pharmacology and GEO Data Analysis
AI-Driven Drug Discovery for Breast Cancer Based on ERBB2 Identified Through Network Pharmacology and GEO Data Analysis Open
Purpose: Breast cancer (BC) is the most prevalent malignancy in women, with current treatments showing limited efficacy and significant side effects. This study aimed to identify therapeutic targets and candidate compounds for BC therapy u…
View article: RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer
RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer Open
Background Resistance to paclitaxel‐based chemotherapy is the major obstacle in triple‐negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whe…
View article: Assessment of the efficacy and safety of pudendal nerve block in post-hemorrhoidectomy pain: A meta-analysis of randomized controlled trials
Assessment of the efficacy and safety of pudendal nerve block in post-hemorrhoidectomy pain: A meta-analysis of randomized controlled trials Open
Hemorrhoid surgeries often result in significant postoperative anal pain, challenging the recovery process. This meta-analysis assessed the efficacy and safety of the pudendal nerve block (PNB), a targeted anesthesia technique, in alleviat…