Eric M. Karp
YOU?
Author Swipe
INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia Open
SUMMARY INPP5D, the gene encoding SHIP1, is genetically associated with Alzheimer’s disease (AD) risk and plays a central role in regulating immune function. Here, we aimed to elucidate the mechanism by which SHIP1 mediates its role in sup…
Counter-current chromatography for lignin monomer–monomer and monomer–oligomer separations from reductive catalytic fractionation oil Open
Counter-current chromatography is an effective unit operation for simultaneous aromatic monomer–monomer and monomer–oligomer separations from oil derived from reductive catalytic fractionation of lignocellulosic biomass.
View article: Solid–liquid separation of lignocellulosic sugars from biomass by rotating ceramic disc filtration
Solid–liquid separation of lignocellulosic sugars from biomass by rotating ceramic disc filtration Open
A simple, low energy, and productive filtration method to clarify biomass hydrolysate to enable biochemical and thermochemical pathways to biofuels and biochemicals.
View article: Liquid–liquid extraction for <i>in situ</i> carboxylic acid recovery <i>via</i> continuous membrane-based emulsion separations
Liquid–liquid extraction for <i>in situ</i> carboxylic acid recovery <i>via</i> continuous membrane-based emulsion separations Open
A membrane-based emulsion separator can enable continuous solvent extraction in bioprocessing separations with substantially improved demulsification and mass transfer rates, including where emulsion formation is a challenge.
Systems and methods for producing nitriles Open
An aspect of the present disclosure is a method that includes a first reacting a molecule from at least one of a carboxylic acid, an ester of a carboxylic acid, and/or an anhydride with ammonia to form a nitrile, where the first reacting i…
Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels Open
Hybrid processes, featuring biological conversion of lignocellulose to small molecules followed by chemo-catalytic conversion to larger molecules suitable for difficult-to-electrify transport modes, are a promising route to biomass-derived…
View article: Separation of bio-based glucaric acid <i>via</i> antisolvent crystallization and azeotropic drying
Separation of bio-based glucaric acid <i>via</i> antisolvent crystallization and azeotropic drying Open
A downstream process was developed for producing pure monopotassium glucarate and crystalline glucaric acid from a fermentation broth.
View article: Recovery of low molecular weight compounds from alkaline pretreatment liquor <i>via</i> membrane separations
Recovery of low molecular weight compounds from alkaline pretreatment liquor <i>via</i> membrane separations Open
Lignin is an abundant renewable resource that is a promising substrate for upgrading to fuels and chemicals.
View article: Novel Approaches to the Isolation of Glucaric Acid from Fermentation Broth. Final report
Novel Approaches to the Isolation of Glucaric Acid from Fermentation Broth. Final report Open
Kalion has successfully demonstrated a fermentation route using glucose as the feedstock. This game-changing technology allows Kalion to economically produce large-scale quantities of high-purity glucaric acid products. Kalion has also dev…
Correction: Adipic acid production from lignin Open
Correction for ‘Adipic acid production from lignin’ by Derek R. Vardon et al. , Energy Environ. Sci. , 2015, 8 , 617–628, https://doi.org/10.1039/C4EE03230F.
Process intensification for the biological production of the fuel precursor butyric acid from biomass Open
The production of fuels from lignocellulosic biomass is key to reduce our reliance on petroleum and to promote a sustainable bioeconomy. Butyric acid (BA) is a promising chemical precursor for the production of renewable diesel and jet fue…
Separations Consortium: Lignin Rich Stream Fractionation and Purification Open
In support of the Bioenergy Technologies Office in converting lignin to fuels and chemicals, this project develops scalable separations based on membranes and Electordeionization (EDI) to recover low molecular weight (LMW) compounds from l…
Energy and techno-economic analysis of bio-based carboxylic acid recovery by adsorption Open
Recent works have established bio-based carboxylic acids as adaptable precursors to renewable biofuels and chemicals.
Making Carbon Fiber Renewable Open
Carbon fiber is an amazing lightweight material for cars and planes but currently made with the chemical acrylonitrile that is produced from an energy-intensive process that produces hydrogen cyanide. Scientists at NREL discovered a ground…
View article: Bioprocessing Separations Consortium Three-Year Overview: Technical Advances, Process Economics Influence, and State of the Science
Bioprocessing Separations Consortium Three-Year Overview: Technical Advances, Process Economics Influence, and State of the Science Open
The Bioprocessing Separations Consortium solves separations challenges that are unique to bioprocessing. To do this, the Consortium uses two methods: applying existing technologies to new challenges and developing new technologies that may…
View article: Bioprocessing Separations Consortium: Three-Year Overview - Technical Advances, Process Economics Influence, and State of the Science
Bioprocessing Separations Consortium: Three-Year Overview - Technical Advances, Process Economics Influence, and State of the Science Open
The Bioprocessing Separations Consortium solves separations challenges that are unique to bioprocessing. To do this, the Consortium uses two methods: applying existing technologies to new challenges and developing new technologies that may…
<i>In situ</i> product recovery of bio-based ethyl esters <i>via</i> hybrid extraction-distillation Open
In situ product recovery (ISPR) of bio-based chemicals from microbial cultivation is a means to improve titer, rate, and yield because it alleviates end product inhibition.
Post-Fermentation Recovery of Biobased Carboxylic Acids Open
Carboxylic acids are common products produced from the bioconversion of renewable feedstocks. In these processes the separation of the acid product from fermentation broth is the most energy and cost intensive unit operation. Thus, the dev…
View article: Catalytic amino acid production from biomass-derived intermediates
Catalytic amino acid production from biomass-derived intermediates Open
Significance Today, amino acids are primarily manufactured via microbial cultivation processes, which are costly, are time consuming, and require extensive separations processes. As an alternative, chemocatalytic approaches to produce amin…
Emulsion polymerization of acrylonitrile in aqueous methanol Open
A new method of acrylonitrile polymerization offers the opportunity to improve both the sustainability and overall economics of renewable carbon fiber precursor production.
<i>In situ</i> recovery of bio-based carboxylic acids Open
The economics of chemical and biological processes is often dominated by the expense of downstream product separations from dilute product streams.
Demonstration of parallel algal processing: production of renewable diesel blendstock and a high-value chemical intermediate Open
Demonstration of a novel integrated algal biomass conversion process for fuels and chemicals.
Renewable acrylonitrile production Open
A sweet source to make acrylonitrile Much of the attention directed toward displacing petroleum feedstocks with biomass has focused on fuels. However, there are also numerous opportunities in commodity chemical production. One such candida…
Mixed Carboxylic Acid Production by Megasphaera elsdenii from Glucose and Lignocellulosic Hydrolysate Open
Volatile fatty acids (VFAs) can be readily produced from many anaerobic microbes and subsequently utilized as precursors to renewable biofuels and biochemicals. Megasphaera elsdenii represents a promising host for production of VFAs, butyr…
Gradient Elution Moving Boundary Electrophoresis Enables Rapid Analysis of Acids in Complex Biomass-Derived Streams Open
Biomass conversion processes such as pretreatment, liquefaction, and pyrolysis often produce complex mixtures of intermediates that are a substantial challenge to analyze rapidly and reliably. To characterize these streams more comprehensi…
Reductive Catalytic Fractionation of Corn Stover Lignin Open
Reductive catalytic fractionation (RCF) has emerged as an effective biomass pretreatment strategy to depolymerize lignin into tractable fragments in high yields. We investigate the RCF of corn stover, a highly abundant herbaceous feedstock…