Eric M. Mulhall
YOU?
Author Swipe
View article: PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models
PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models Open
Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and progressive blindness in the form of retinitis pigmentosa. In this study, we ex…
View article: PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F
PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F Open
Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and progressive blindness in the form of retinitis pigmentosa. In this study, we ex…
View article: Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F
Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F Open
Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene ( PCDH15 ), is characterized by congenital deafness, lack of balance, and progressive blindness. In hair cells, the receptor cells of the inner ear, PCDH15 i…
View article: The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and Deafness
The Dynamic Strength of the Hair-Cell Tip Link Reveals Mechanisms of Hearing and Deafness Open
Our senses of hearing and balance rely on the extraordinarily sensitive molecular machinery of the inner ear to convert deflections as small as the width of a single carbon atom 1,2 into electrical signals that the brain can process 3 . In…
View article: The K <sup>+</sup> channel K <sub>IR</sub> 2.1 functions in tandem with proton influx to mediate sour taste transduction
The K <sup>+</sup> channel K <sub>IR</sub> 2.1 functions in tandem with proton influx to mediate sour taste transduction Open
Significance Among the five basic tastes, sour is one of the least understood. Notably, the sour receptor remains to be identified, and molecular mechanisms by which sour stimuli are detected are largely not known. Previous work has shown …