Eric M. Wier
YOU?
Author Swipe
View article: RNase L represses hair follicle regeneration through altered innate immune signaling
RNase L represses hair follicle regeneration through altered innate immune signaling Open
Mammalian injury responses are predominantly characterized by fibrosis and scarring rather than functional regeneration. This limited regenerative capacity in mammals could reflect a loss of proregeneration programs or active suppression b…
View article: On‐Chip Reconstitution of Uniformly Shear‐Sensing 3D Matrix‐Embedded Multicellular Blood Microvessel
On‐Chip Reconstitution of Uniformly Shear‐Sensing 3D Matrix‐Embedded Multicellular Blood Microvessel Open
Preclinical human‐relevant modeling of organ‐specific vasculature offers a unique opportunity to recreate pathophysiological intercellular, tissue‐tissue, and cell‐matrix interactions for a broad range of applications. Here, this work pres…
View article: Supplementary Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Supplementary Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis Open
Supplementary data contain Supplementary Table 1-3 and Supplementary Figures 1-11.
View article: Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis Open
Chronic and low-grade inflammation associated with persistent bacterial infections has been linked to colon tumor development; however, the impact of transient and self-limited infections in bacterially driven colon tumorigenesis has remai…
View article: Supplementary Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Supplementary Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis Open
Supplementary data contain Supplementary Table 1-3 and Supplementary Figures 1-11.
View article: Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Data from Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis Open
Chronic and low-grade inflammation associated with persistent bacterial infections has been linked to colon tumor development; however, the impact of transient and self-limited infections in bacterially driven colon tumorigenesis has remai…
View article: Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism
Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1α signaling and glutamine metabolism Open
Tissue injury induces metabolic changes in stem cells, which likely modulate regeneration. Using a model of organ regeneration called wound-induced hair follicle neogenesis (WIHN), we identified skin-resident bacteria as key modulators of …
View article: 29. Mechanical Stretch Mobilizes Lgr6+ Epidermal Stem Cells to Drive Skin Growth
29. Mechanical Stretch Mobilizes Lgr6+ Epidermal Stem Cells to Drive Skin Growth Open
Purpose: Current research in the field of wound regeneration has identified distinct populations of stem cells within specific skin components that regularly replenish the epidermis and hair follicles. The purpose of this study was to iden…
View article: Mechanical tension mobilizes Lgr6 <sup>+</sup> epidermal stem cells to drive skin growth
Mechanical tension mobilizes Lgr6 <sup>+</sup> epidermal stem cells to drive skin growth Open
Uniquely among mammalian organs, skin is capable of marked size change in adults, yet the mechanisms underlying this notable capacity are unclear. Here, we use a system of controlled tissue expansion in mice to uncover cellular and molecul…
View article: 29. MECHANICAL STRETCH MOBILIZES LGR6+ EPIDERMAL STEM CELLS TO DRIVE SKIN GROWTH
29. MECHANICAL STRETCH MOBILIZES LGR6+ EPIDERMAL STEM CELLS TO DRIVE SKIN GROWTH Open
PURPOSE: To uncover cellular and molecular determinants of skin growth with the goal of designing future therapies for conditions of excess or inadequate skin. Current research in the field has identified distinct populations of stem cells…
View article: Neutrophil extracellular traps impair regeneration
Neutrophil extracellular traps impair regeneration Open
Fibrosis is a major health burden across diseases and organs. To remedy this, we study wound‐induced hair follicle neogenesis (WIHN) as a model of non‐fibrotic healing that recapitulates embryogenesis for de novo hair follicle morphogenesi…
View article: Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis
Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis Open
Chronic and low-grade inflammation associated with persistent bacterial infections has been linked to colon tumor development; however, the impact of transient and self-limited infections in bacterially driven colon tumorigenesis has remai…
View article: Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease Open
IgE induced by type 2 immune responses in atopic dermatitis is implicated in the progression of atopic dermatitis to other allergic diseases, including food allergies, allergic rhinitis, and asthma. However, the keratinocyte-derived signal…
View article: Neutrophil extracellular traps impair regeneration
Neutrophil extracellular traps impair regeneration Open
Fibrosis is a major health burden across diseases and organs. To remedy this, we study wound induced hair follicle regeneration (WIHN) as a model of non-fibrotic healing that recapitulates embryogenesis for de novo hair follicle morphogene…
View article: Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 Open
How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regene…
View article: Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice
Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice Open
Previously we reported that Src-associated-substrate-during-mitosis-of-68kDa (Sam68/KHDRBS1) is pivotal for DNA damage-stimulated NF-κB transactivation of anti-apoptotic genes (Fu et al., 2016). Here we show that Sam68 is critical for geno…
View article: Author response: Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice
Author response: Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Previously we reported that Src-associated-substrate-during-…
View article: Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation
Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation Open
The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. However, the precise mechanisms t…
View article: Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in <i>Apc</i><sup>min716/+</sup> mice
Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in <i>Apc</i><sup>min716/+</sup> mice Open
Animal models of colon cancer are widely used to understand the molecular mechanisms and pathogenesis of the disease. These animal models require a substantial investment of time and traditionally necessitate the killing of the animal to m…
View article: Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation Open
Nuclear factor kappa B (NF-κB)-mediated transcription is an important mediator for cellular responses to DNA damage. Genotoxic agents trigger a 'nuclear-to-cytoplasmic' NF-κB activation signaling pathway; however, the early nuclear signali…
View article: Author response: Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
Author response: Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Nuclear factor kappa B (NF-κB)-mediated transcr…