Eric P. Zorrilla
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View article: Global index of lifestyle quality and non-suicidal self-injury in the SESSAMO project: a Spanish adolescents cohort
Global index of lifestyle quality and non-suicidal self-injury in the SESSAMO project: a Spanish adolescents cohort Open
Adolescents’ failure to embrace healthy lifestyles constitutes a serious public health issue, such that its relationship to non-suicidal self-injury (NSSI) merits further research. The aim of the study was to ascertain the association betw…
View article: Psychopathological profiles of adolescent presenting to emergency departments following a suicide attempt: A comprehensive analysis
Psychopathological profiles of adolescent presenting to emergency departments following a suicide attempt: A comprehensive analysis Open
Identifying symptom profiles among adolescents who have attempted suicide provides a valuable framework for guiding suicide prevention and personalized interventions. These findings support the use of tailored approaches, such as DBT-A or …
View article: Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use
Scoping review of biological and psychosocial pathways that lead from childhood adversity to early-onset substance use Open
Background and objectives Substance use in children and adolescents exposed to childhood adversity is a recognized risk factor for adverse outcomes in mental and physical health. However, few studies focus on the specific mechanisms that l…
View article: Short Research Article: Independent association between household income and family adversity and bipolar disorder in adolescence and young adulthood – a registry‐data study in the Basque Country
Short Research Article: Independent association between household income and family adversity and bipolar disorder in adolescence and young adulthood – a registry‐data study in the Basque Country Open
Background The objective of this study was to estimate separately the excess risk associated with household income and head of household employment status (as an index of family adversity) as socioeconomic risk factors for the incidence of…
View article: Influence of polygenic risk for schizophrenia and cannabis use on cognition
Influence of polygenic risk for schizophrenia and cannabis use on cognition Open
Introduction There is increasing scientific evidence linking the influence of cannabis on the onset of a first psychotic episode (FEP). However, this association may not always be one-way when studying the relationship between cannabis use…
View article: Inflammatory biomarkers and risk factors in depression: a longitudinal study in adults
Inflammatory biomarkers and risk factors in depression: a longitudinal study in adults Open
Introduction Depression is a chronic and recurrent mental condition, causing a high burden of disease, functional impairment, and significant economic costs worldwide. Objectives To compare the neuropsychological profile, inflammation, and…
View article: Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia
Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia Open
Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculati…
View article: Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT‐BD Study
Are Adults With Bipolar Disorder at Increased Cardiovascular Risk due to Their Physical, Biochemical, and Physiological Profiles? The FINEXT‐BD Study Open
Introduction Bipolar disorder (BD) is associated with considerable morbidity and premature mortality, mainly due to somatic causes. This study aims to determine some physical, exercise capacity–related physiological variables and biochemic…
View article: Peripheral inflammation and neurocognitive functioning in early psychosis: Specific associations of TNF-α and IL-6 with social cognition
Peripheral inflammation and neurocognitive functioning in early psychosis: Specific associations of TNF-α and IL-6 with social cognition Open
Background Cognitive deficits and immune system dysregulation are core features of psychotic disorders. Among inflammatory markers, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) have been linked to both psychosis pathophysi…
View article: Efficacy of a brief psychological intervention for adolescents with recent suicide attempt: A randomized clinical trial
Efficacy of a brief psychological intervention for adolescents with recent suicide attempt: A randomized clinical trial Open
Background Adolescents are at a heightened risk of suicide reattempts following hospital discharge, but few evidence-based interventions exist. This study evaluated the efficacy of the self-awareness of mental health (SAM) program combined…
View article: All-cause mortality risk in long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis
All-cause mortality risk in long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis Open
Patients with schizophrenia receiving antipsychotic treatment present lower mortality rates than those who do not. However, the non-adherence rate is high, which can be partially addressed using long-acting injectable (LAI) antipsychotics.…
View article: Validation of the Spanish Childhood Trauma Questionnaire-Short Form in adolescents with suicide attempts
Validation of the Spanish Childhood Trauma Questionnaire-Short Form in adolescents with suicide attempts Open
Background Child maltreatment is associated with a higher probability of mental disorders and suicidal behavior in adolescence. Therefore, accurate psychometric instruments are essential to assess this. Objective To validate the Spanish ve…
View article: Probing the oral-brain connection: Oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes
Probing the oral-brain connection: Oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes Open
The role of the oral microbiome in mental health has recently been appreciated within the proposed oral-brain axis. This study examined the structure and composition of the salivary microbiome in a large-scale population-based cohort of in…
View article: Areas of interest and sentiment analysis towards second generation antipsychotics, lithium and mood stabilizing anticonvulsants: Unsupervised analysis using Twitter
Areas of interest and sentiment analysis towards second generation antipsychotics, lithium and mood stabilizing anticonvulsants: Unsupervised analysis using Twitter Open
This study emphasizes the importance of social media research in understanding user perceptions of SRD and BD treatments. The results provide valuable insights for clinicians when considering how patients and the general public view and co…
View article: Efficacy and Safety of Calcifediol in Young Adults with Vitamin D Deficiency: A Phase I, Multicentre, Clinical Trial—POSCAL Study
Efficacy and Safety of Calcifediol in Young Adults with Vitamin D Deficiency: A Phase I, Multicentre, Clinical Trial—POSCAL Study Open
Vitamin D deficiency is highly prevalent, and recent evidence suggests a possible association between vitamin D deficiency and various health conditions. The aim of this study was to assess monthly calcifediol treatments for vitamin D defi…
View article: SESSAMO, follow-up of secondary students to assess mental health and obesity: a cohort study
SESSAMO, follow-up of secondary students to assess mental health and obesity: a cohort study Open
During last decades, a departure from health-related lifestyles has been observed among adolescents. Evidence reports that healthy lifestyles could be predictors of better mental health status. The aims of the SESSAMO Project are: 1) to as…
View article: Mediating role of allostatic load in psychiatric patients exposed to maltreatment: a study from a young Spanish sample
Mediating role of allostatic load in psychiatric patients exposed to maltreatment: a study from a young Spanish sample Open
Child maltreatment (CM) is usually a chronic stress condition on which the child constantly deals with inner fear and elevated distress. This experience can damage the adaptive stress-response systems, as the HPA axis [1], affecting also o…
View article: Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder? Open
To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptom…
View article: Complex post-traumatic stress disorder (CPTSD) of ICD-11 in youths with childhood maltreatment: Associations with age of exposure and clinical outcomes
Complex post-traumatic stress disorder (CPTSD) of ICD-11 in youths with childhood maltreatment: Associations with age of exposure and clinical outcomes Open
Gathering information on type and age of exposure to CM is clinically useful to understand the complexity of psychiatric symptoms observed in youths. Inclusion of the CPTSD diagnosis should increase the implementation of early specific int…
View article: Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents
Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents Open
Background As mental health in adulthood is related to mental status during adolescence, school-based interventions have been proposed to improve resilience. The objective of this study was to build a simulation model representing the natu…