Huw R. Morris
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View article: Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease Open
Dementia in Lewy body diseases (LBD) is common and arises through heterogeneous and incompletely understood pathways. Evidence suggests contributions from genetic factors, including APOE ε4 genotype, co-pathology including concomitant Alzh…
View article: Exploring MAPT-containing H1 and H2 haplotypes in Parkinson’s disease across diverse populations
Exploring MAPT-containing H1 and H2 haplotypes in Parkinson’s disease across diverse populations Open
Variation at the 17q21.31 locus, which contains the gene encoding microtubule-associated protein tau ( MAPT ), has been associated with neurodegenerative disorders, including Parkinson’s disease (PD). This highly complex locus is character…
View article: Rare but Relevant? Assessing Variants in Dystonia‐Linked Genes in Parkinson's Disease
Rare but Relevant? Assessing Variants in Dystonia‐Linked Genes in Parkinson's Disease Open
Background Dystonia and Parkinson's disease (PD) exhibit clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective The aim was to assess the frequency of dystonia‐linked pathogenic variants …
View article: Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations
Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations Open
Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization…
View article: Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease
Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease Open
REM sleep behavior disorder (RBD), is a prodromal synucleinopathy affecting a subset of Parkinson’s disease (PD) patients and associated with neuropsychiatric symptoms. This study compared the genetic profiles of 13,020 PD patients with pr…
View article: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities
Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities Open
The need for more diversity in research is a widely recognized problem, especially in the genetics and genomics fields. While resolving this problem seems straightforward by recruiting and sequencing research participants from underreprese…
View article: Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes
Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes Open
Progressive supranuclear palsy (PSP) is a heterogeneous neurodegenerative disease characterised by the accumulation of misfolded 4-repeat tau within neurones and glial cells. There is limited longitudinal data on pathologically confirmed P…
View article: Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy
Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy Open
Objective Exenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof‐of‐concept clinical trial. Methods In thi…
View article: The Global Landscape of Genetic Variation in Parkinson’s disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance
The Global Landscape of Genetic Variation in Parkinson’s disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance Open
Background The genetic architecture of Parkinson’s disease (PD) varies considerably across ancestries, yet most genetic studies have focused on individuals of European descent, limiting our insights into the genetic architecture of PD at a…
View article: Rare but Relevant: Assessing Variants in Dystonia-linked Genes in Parkinson’s Disease
Rare but Relevant: Assessing Variants in Dystonia-linked Genes in Parkinson’s Disease Open
Background Dystonia and Parkinson’s disease (PD) show clinical and genetic overlap, but the relevance of dystonia gene variants in PD remains unclear. Objective To assess the frequency of dystonia-linked pathogenic variants in PD. Methods …
View article: Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study
Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study Open
© 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
View article: Clinical Diagnosis of Progressive Supranuclear Palsy (PSP): A Clinicopathological Comparison of Patients with Confirmed PSP and Clinical Mimics
Clinical Diagnosis of Progressive Supranuclear Palsy (PSP): A Clinicopathological Comparison of Patients with Confirmed PSP and Clinical Mimics Open
Background Several neurodegenerative diseases can mimic the clinical presentation of progressive supranuclear palsy (PSP), limiting accurate diagnosis during life. This has important implications for clinical practice, biomarker studies, a…
View article: Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson’s disease etiology across diverse ancestral populations
Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson’s disease etiology across diverse ancestral populations Open
Objective We conducted the first large-scale, multi-ancestral investigation of Parkinson’s disease (PD) to examine the impact of genome-wide homozygosity on disease risk and age at onset. Using genotyping, imputed, and whole-genome sequenc…
View article: The role of dopaminergic medication and specific pathway alterations in idiopathic and <i>PRKN/PINK1</i> -mediated Parkinson’s disease
The role of dopaminergic medication and specific pathway alterations in idiopathic and <i>PRKN/PINK1</i> -mediated Parkinson’s disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease, with a rapidly increasing prevalence worldwide. Biomarkers monitoring state and progression are urgently needed, and metabolomics from easily accessible biofluid…
View article: Cryo-EM structures of filaments from the brains of individuals with variants G51D and H50Q in α-synuclein
Cryo-EM structures of filaments from the brains of individuals with variants G51D and H50Q in α-synuclein Open
Gene dosage and point mutations in SNCA, the a-synuclein gene, give rise to familial forms of Parkinson’s disease and dementia with Lewy bodies; an insertion mutation in SNCA causes juvenile-onset synucleinopathy. We previously reported th…
View article: Intronic <i>FGF14</i> GAA repeat expansions impact progression and survival in multiple system atrophy
Intronic <i>FGF14</i> GAA repeat expansions impact progression and survival in multiple system atrophy Open
Partial phenotypic overlap has been suggested between multiple system atrophy and spinocerebellar ataxia 27B, the autosomal dominant ataxia caused by an intronic GAA•TTC repeat expansion in FGF14. In this study, we investigated the frequen…
View article: Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes
Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes Open
Atypical parkinsonian syndromes are distinguished from Parkinson's disease (PD) by additional neurological signs and characteristic underlying neuropathology. However, they can be diagnostically challenging, rapidly progressive and are oft…
View article: Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism
Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism Open
View article: The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population
The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population Open
LRRK2 -PD represents the most common form of autosomal dominant Parkinson’s disease. We identified the LRRK2 p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers wi…
View article: 17q21.31 locus regulates Parkinson’s disease relevant pathways through <i>KANSL1</i> activity
17q21.31 locus regulates Parkinson’s disease relevant pathways through <i>KANSL1</i> activity Open
An inversion polymorphism at the 17q21.31 locus defines the H1 and H2 haplotypes, with the former linked to multiple neurodegenerative disorders, including an increased risk of Parkinson’s disease (PD). Although the high linkage disequilib…
View article: Copy Number Variation and Haplotype Analysis of <scp>17q21.31</scp> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
Copy Number Variation and Haplotype Analysis of <span>17q21.31</span> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells Open
Background The 17q21.31 region with various structural forms characterized by the H1/H2 haplotypes and three large copy number variations (CNVs) represents the strongest risk locus in progressive supranuclear palsy (PSP). Objective To inve…
View article: Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementia
Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementia Open
Parkinson’s disease (PD) affects millions of people worldwide, and up to 40% of these patients develop dementia, profoundly affecting their quality of life. Whether Parkinson’s disease dementia (PDD) simply represents a late stage of PD or…
View article: Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial
Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial Open
National Institute for Health and Care Research and Cure Parkinson's.
View article: Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations
Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations Open
Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization…
View article: Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies
Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies Open
Although the corticobasal syndrome was originally most closely linked with the pathology of corticobasal degeneration, the 2013 Armstrong clinical diagnostic criteria, without the addition of aetiology-specific biomarkers, have limited pos…
View article: Global Perspectives on Returning Genetic Research Results in Parkinson Disease
Global Perspectives on Returning Genetic Research Results in Parkinson Disease Open
Given the differences in resources and training for RoR, as well as ethical and regulatory considerations, tailored approaches are required to ensure equitable access to RoR. Several identified strategies to enhance RoR practices include i…
View article: African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1 Open
View article: Identification of regional and cell type‐specific gene dysregulation in Progressive Supranuclear Palsy
Identification of regional and cell type‐specific gene dysregulation in Progressive Supranuclear Palsy Open
Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder involving pathological deposition of tau that includes glial inclusions and specific regional vulnerability patterns. Therapeutic developments are hampered by …
View article: CNV-Finder: Streamlining Copy Number Variation Discovery
CNV-Finder: Streamlining Copy Number Variation Discovery Open
Copy Number Variations (CNVs) play pivotal roles in the etiology of complex diseases and are variable across diverse populations. Understanding the association between CNVs and disease susceptibility is significant in disease genetics rese…
View article: Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes
Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes Open