Eric N. Olson
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View article: Infrared Thermal Imaging Enhanced Selection Intensity for Fusarium Head Blight Resistance in Soft Winter Wheat
Infrared Thermal Imaging Enhanced Selection Intensity for Fusarium Head Blight Resistance in Soft Winter Wheat Open
Development of Fusarium head blight (FHB)‐resistant winter wheat ( Triticum aestivum L.) varieties relies heavily on visual scoring for large‐scale field evaluations. However, visual assessment of FHB symptoms remains a bottleneck in FHB r…
View article: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells Open
Generation of in vitro human induced pluripotent cell (hiPSC)-derived skeletal muscle progenitor cells (SMPCs) holds great promise for regenerative medicine for skeletal muscle wasting diseases, for example Duchenne muscular dystrophy (DMD…
View article: Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease
Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease Open
Mutations in the Lamin A ( LMNA ) gene, which encodes the Lamin A and C proteins, cause severe human diseases collectively known as laminopathies. These conditions are often devastating and lack effective therapies. In this study, we devel…
View article: Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain
Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain Open
Differentiation of smooth muscle cells (SMCs) is driven by the activation of a set of genes controlled by serum response factor (SRF), a ubiquitous transcription factor with limited intrinsic transcriptional activity. Myocardin (MYOCD) is …
View article: Gene Editing Applications as Future Cardiovascular Therapies
Gene Editing Applications as Future Cardiovascular Therapies Open
Cardiovascular disease is the leading cause of global morbidity and mortality, despite advances in pharmacological and surgical interventions. The emergence of CRISPR-Cas9 genome editing technology offers promising approaches for correctin…
View article: Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction
Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction Open
BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart disease. However, current reprogramming strategies require excessive factors due to epigenetic barriers of adult mouse …
View article: A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases
A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases Open
Neuromuscular diseases such as amyotrophic lateral sclerosis and sarcopenia cause muscle atrophy, which preferentially affects fast-twitch glycolytic myofibers. The mechanisms underlying the susceptibility of fast myofibers to disease rema…
View article: Equivalence between Capillary Blood and Venous Blood Test Results Using Miniaturized Assays and Novel Collection Methods to Support Routine Bloodwork
Equivalence between Capillary Blood and Venous Blood Test Results Using Miniaturized Assays and Novel Collection Methods to Support Routine Bloodwork Open
Background Capillary blood testing has potential to improve accessibility and adherence for routine tests. Due to historical challenges with sample volume and quality, capillary blood is rarely used for diagnostic testing. These studies pr…
View article: Genomic Editing of a Pathogenic Sequence Variant in <i>ACTA2</i> Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice
Genomic Editing of a Pathogenic Sequence Variant in <i>ACTA2</i> Rescues Multisystemic Smooth Muscle Dysfunction Syndrome in Mice Open
BACKGROUND: Vascular smooth muscle cells (SMCs), the predominant cell type in the aortic wall, play a crucial role in maintaining aortic integrity, blood pressure, and cardiovascular function. Vascular SMC contractility and function depend…
View article: SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics
SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics Open
Hospitalized participants initially develop higher anti-SARS-CoV-2 antibody titers that decline faster relative to non-hospitalized participants. While anti-N titers fall below control levels in some participants, anti-RBD titers remain ab…
View article: Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSCs-derived myogenic progenitor cells
Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSCs-derived myogenic progenitor cells Open
Summary Generation of in vitro induced pluripotent cells (hiPSCs)-derived skeletal muscle progenitor cells (SMPCs) holds great promise for regenerative medicine for skeletal muscle wasting diseases, as for example Duchenne Muscular Dystrop…
View article: A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution Open
Cancer cachexia is a prevalent and often fatal wasting condition that cannot be fully reversed with nutritional interventions. Muscle atrophy is a central component of the syndrome, but the mechanisms whereby cancer leads to skeletal muscl…
View article: Coactivator condensation drives cardiovascular cell lineage specification
Coactivator condensation drives cardiovascular cell lineage specification Open
During development, cells make switch-like decisions to activate new gene programs specifying cell lineage. The mechanisms underlying these decisive choices remain unclear. Here, we show that the cardiovascular transcriptional coactivator …
View article: CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway
CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway Open
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases. The long-term event-free survival rate for patients with high-grad…
View article: Digital Transformation and AI in Energy Systems: Applications, Challenges, and the Path Forward
Digital Transformation and AI in Energy Systems: Applications, Challenges, and the Path Forward Open
The integration of digital technologies like Machine Learning (ML), Artificial Intelligence (AI), and the Internet of Things is transforming energy systems. This digital transformation aims to enhance efficiency, sustainability, and resili…
View article: SARS-CoV-2 Humoral Immune Responses in Convalescent Individuals Over 12 Months Reveal Severity-Dependent Antibody Dynamics
SARS-CoV-2 Humoral Immune Responses in Convalescent Individuals Over 12 Months Reveal Severity-Dependent Antibody Dynamics Open
Background Understanding the kinetics and longevity of antibody responses to SARS-CoV-2 is critical to informing strategies toward reducing Coronavirus disease 2019 (COVID-19) reinfections, and improving vaccination and therapy approaches.…
View article: DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters
DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters Open
BACKGROUND: The p.Arg14del variant of the PLN (phospholamban) gene causes cardiomyopathy, leading to severe heart failure. Calcium handling defects and perinuclear PLN aggregation have both been suggested as pathological drivers of this di…
View article: RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing
RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing Open
Aims RNA binding proteins play essential roles in mediating RNA splicing and are key post-transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA binding protein with multiple splicing) is crucial for cardiac…
View article: CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model
CRISPR-Cas9 base editing of pathogenic CaMKIIδ improves cardiac function in a humanized mouse model Open
Cardiovascular diseases are the most common cause of worldwide morbidity and mortality, highlighting the necessity for advanced therapeutic strategies. Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is a prominent inducer of variou…
View article: Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice
Elimination of CaMKIIδ Autophosphorylation by CRISPR-Cas9 Base Editing Improves Survival and Cardiac Function in Heart Failure in Mice Open
BACKGROUND: Cardiovascular diseases are the main cause of worldwide morbidity and mortality, highlighting the need for new therapeutic strategies. Autophosphorylation and subsequent overactivation of the cardiac stress-responsive enzyme Ca…
View article: Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy
Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy Open
Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of …
View article: #4286 ACCUMULATION OF MALADAPTIVE TUBULAR EPITHELIAL CELLS (TECS) IS UBIQUITOUS IN CKD AND REPRESENTS A COMMON INITIATING MECHANISM OF DISEASE PROGRESSION
#4286 ACCUMULATION OF MALADAPTIVE TUBULAR EPITHELIAL CELLS (TECS) IS UBIQUITOUS IN CKD AND REPRESENTS A COMMON INITIATING MECHANISM OF DISEASE PROGRESSION Open
Background and Aims Interstitial fibrosis, tubular atrophy and inflammation are common final pathways to end-stage kidney disease (ESKD), contributing to progressive nephron loss and functional decline in most chronic kidney diseases (CKD)…