Eric Perkey
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View article: Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation
Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation Open
A better understanding of the mechanisms regulating CD8+ T cell differentiation is essential to develop new strategies to fight infections and cancer. Using genetic mouse models and blocking antibodies, we uncovered cellular and molecular …
View article: The follicular lymphoma and chronic lymphocytic leukemia proliferative microenvironment at single-cell resolution
The follicular lymphoma and chronic lymphocytic leukemia proliferative microenvironment at single-cell resolution Open
Lymph nodes (LNs) are secondary lymphoid organs where lymphocytes interact with antigen presenting cells to initiate adaptive immune responses within microenvironments established by resident stromal cells. LNs are also the major site of g…
View article: The Follicular Lymphoma and Chronic Lymphocytic Leukemia Proliferative Microenvironment at Single-Cell Resolution
The Follicular Lymphoma and Chronic Lymphocytic Leukemia Proliferative Microenvironment at Single-Cell Resolution Open
Introduction Lymph nodes (LNs) are secondary lymphoid organs where lymphocytes interact with antigen presenting cells to initiate adaptive immune responses within microenvironments established by resident stromal cells. LNs are also the ma…
View article: Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen
Stroma-Driven Notch2 Signaling Controls Naïve B Cell Fate By Regulating Microenvironmental Positioning within the Spleen Open
Marginal zone (MZ) B cells are naïve innate-like B cells that function as a first line of defense in the spleen within the blood-rich marginal zone. Previous research revealed a critical role for Notch2 receptors in B cells and Delta-like1…
View article: Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates Open
Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. To assess whether Notch’s…
View article: DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance
DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance Open
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Up to 40% of patients with DLBCL display refractory disease or relapse after standard chemotherapy treatment (rituximab, cyclophosphamide, doxorubici…
View article: Supplementary Table S3 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S3 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S3. Excel file containing the statistical analysis of the 184 FL targets with significant inverse correlation with BCL6.
View article: Supplementary Table S1 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S1 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S1. BCL6 target genes on FL patient samples ChIp-onChIP.
View article: Supplementary Table S2 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S2 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S2. Gene sets that are enriched among BCL6 target genes in FL samples.
View article: Supplementary Table S6 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S6 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S6. DLBCL p-values on DLBCL signatures. (See Supplementary Figure S1E).
View article: Supplementary Methods, Figures 1 - 8, Table 5 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Methods, Figures 1 - 8, Table 5 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Figure S1. BCL6 displays a specific genomic localization pattern in FL. Supplementary Figure S2. Inverse correlation between BCL6 and NOTCH2 complex genes in primary GC B-cells. Supplementary Figure S3. GC reaction is impaire…
View article: Supplementary Table S2 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S2 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S2. Gene sets that are enriched among BCL6 target genes in FL samples.
View article: Supplementary Table S7 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S7 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S7. BCL6 target genes in GCB-DLBCL. Spearman and rho. (See Supplementary Figure S1F).
View article: Supplementary Table S7 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S7 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S7. BCL6 target genes in GCB-DLBCL. Spearman and rho. (See Supplementary Figure S1F).
View article: Supplementary Table S4 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S4 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S4. p value of NOTCH2 target genes and members of its transcriptional complex that are inversely correlated to BCL6 in primary FL specimens.
View article: Data from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Data from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (FL), its biological role in this disease remains unknown. Herein, we comprehensively identify the set of gene promoters directly targeted by…
View article: Supplementary Table S9 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S9 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S9. Overlap BCL6 target genes on FL and DLBCL datasets. (See Figure 1B for full FL datasets and Supplementary Figure S1F for DLBCL datasets).
View article: Data from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Data from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (FL), its biological role in this disease remains unknown. Herein, we comprehensively identify the set of gene promoters directly targeted by…
View article: Supplementary Table S8 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S8 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S8. DLBCL p-values and rho values on GCB-DLBCL probesets for Notch2 pathway genes. (See Supplementary Figure S1G).
View article: Supplementary Table S4 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S4 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S4. p value of NOTCH2 target genes and members of its transcriptional complex that are inversely correlated to BCL6 in primary FL specimens.
View article: Supplementary Table S10 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S10 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S10. p value of NOTCH2 target genes and members of its transcriptional complex that are inversely correlated to BCL6 in primary GC B-cells.
View article: Supplementary Table S6 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S6 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S6. DLBCL p-values on DLBCL signatures. (See Supplementary Figure S1E).
View article: Supplementary Table S3 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S3 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S3. Excel file containing the statistical analysis of the 184 FL targets with significant inverse correlation with BCL6.
View article: Supplementary Table S8 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S8 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S8. DLBCL p-values and rho values on GCB-DLBCL probesets for Notch2 pathway genes. (See Supplementary Figure S1G).
View article: Supplementary Table S1 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S1 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S1. BCL6 target genes on FL patient samples ChIp-onChIP.
View article: Supplementary Table S9 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S9 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S9. Overlap BCL6 target genes on FL and DLBCL datasets. (See Figure 1B for full FL datasets and Supplementary Figure S1F for DLBCL datasets).
View article: Supplementary Methods, Figures 1 - 8, Table 5 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Methods, Figures 1 - 8, Table 5 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Figure S1. BCL6 displays a specific genomic localization pattern in FL. Supplementary Figure S2. Inverse correlation between BCL6 and NOTCH2 complex genes in primary GC B-cells. Supplementary Figure S3. GC reaction is impaire…
View article: Supplementary Table S10 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Supplementary Table S10 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells Open
Supplementary Table S10. p value of NOTCH2 target genes and members of its transcriptional complex that are inversely correlated to BCL6 in primary GC B-cells.