Eric R. Espinal
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Group B <i>Streptococcus</i> transcriptome when interacting with brain endothelial cells Open
Bacterial meningitis is a life-threatening infection of the central nervous system (CNS) that occurs when bacteria are able to cross the blood–brain barrier (BBB) or the meningeal–cerebrospinal fluid barrier (mBCSFB). The BBB and mBCSFB co…
Coxsackievirus B3 infects and disrupts human induced-pluripotent stem cell derived brain-like endothelial cells Open
Coxsackievirus B3 (CVB3) is a significant human pathogen that is commonly found worldwide. CVB3 among other enteroviruses, are the leading causes of aseptic meningo-encephalitis which can be fatal especially in young children. How the viru…
Synthesis and Characterization of Quercetin–Iron Complex Nanoparticles for Overcoming Drug Resistance Open
Quercetin, one of the major natural flavonoids, has demonstrated great pharmacological potential as an antioxidant and in overcoming drug resistance. However, its low aqueous solubility and poor stability limit its potential applications. …
Group B Streptococcus-Induced Macropinocytosis Contributes to Bacterial Invasion of Brain Endothelial Cells Open
Bacterial meningitis is defined as serious inflammation of the central nervous system (CNS) in which bacteria infect the blood–brain barrier (BBB), a network of highly specialized brain endothelial cells (BECs). Dysfunction of the BBB is a…