Eric R. Gremmer
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View article: Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells
Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells Open
View article: <i>In Vitro</i> Assessment of Translocation and Toxicological Effects of Nicotine and Ethyl Maltol from e-Cigarettes Using Air–Liquid Interface-Cultured Bronchial Epithelial Cells
<i>In Vitro</i> Assessment of Translocation and Toxicological Effects of Nicotine and Ethyl Maltol from e-Cigarettes Using Air–Liquid Interface-Cultured Bronchial Epithelial Cells Open
Introduction: The use of e-cigarettes is increasing rapidly. As only scant information is available on the toxicological hazard of inhaling flavoring compounds in e-liquids, we assessed effects of the widely used flavoring ethyl maltol on …
View article: Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test
Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test Open
View article: Transferability and reproducibility of exposed air-liquid interface co-culture lung models
Transferability and reproducibility of exposed air-liquid interface co-culture lung models Open
View article: 97 Transferability and Reproducibility of Exposed Air-Liquid Interface co-Culture Lung Models
97 Transferability and Reproducibility of Exposed Air-Liquid Interface co-Culture Lung Models Open
The establishment of reliable and robust in vitro models for hazard assessment, moving away from animal testing, requires evaluation of model transferability and reproducibility. Lung models that can be exposed via the air, by means of an …
View article: Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function
Smoking-Associated Exposure of Human Primary Bronchial Epithelial Cells to Aldehydes: Impact on Molecular Mechanisms Controlling Mitochondrial Content and Function Open
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formald…
View article: An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials
An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials Open
View article: Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action
Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action Open
This case study of a complex mixture inducing craniofacial malformations in zebrafish embryos shows that dose addition can adequately predicted the cumulative effect of a mixture of multiple substances at low doses, irrespective of the (ex…
View article: Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures
Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures Open
View article: An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing Open
For toxicity testing of airborne particles, air-liquid interface (ALI) exposure systems have been developed for in vitro tests in order to mimic realistic exposure conditions. This puts specific demands on the cell culture models. Many cel…
View article: Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures
Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures Open
View article: Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos
Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos Open
View article: Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds
Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds Open
View article: Is current risk assessment of non-genotoxic carcinogens protective?
Is current risk assessment of non-genotoxic carcinogens protective? Open
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With…
View article: Effects of Higher Doses of Vitamin E on Toxicity and Inflammation
Effects of Higher Doses of Vitamin E on Toxicity and Inflammation Open
View article: Is current risk assessment of non-genotoxic carcinogens protective?
Is current risk assessment of non-genotoxic carcinogens protective? Open
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With…
View article: Multi-omics approaches confirm metal ions mediate the main toxicological pathways of metal-bearing nanoparticles in lung epithelial A549 cells
Multi-omics approaches confirm metal ions mediate the main toxicological pathways of metal-bearing nanoparticles in lung epithelial A549 cells Open
Our analyses confirm that the dissolution of metal ions mediates the main toxicological pathways of silver and zinc oxide nanoparticles.
View article: Is current risk assessment of non-genotoxic carcinogens protective?
Is current risk assessment of non-genotoxic carcinogens protective? Open
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With…
View article: Tissue-Specific Effects of Vitamin E Supplementation
Tissue-Specific Effects of Vitamin E Supplementation Open
A multivitamin and mineral supplementation study of 6 weeks was conducted with male and female mice. The control group received a standard dose of vitamins and minerals of 1× the Recommended Daily Intake (RDI), whereas a second group recei…
View article: Developmental immunotoxicity testing of 4-methyl anisole
Developmental immunotoxicity testing of 4-methyl anisole Open