Eric J. Rubin
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View article: High-throughput cytological profiling uncovers genotype-phenotype associations in Mycobacterium tuberculosis clinical isolates.
High-throughput cytological profiling uncovers genotype-phenotype associations in Mycobacterium tuberculosis clinical isolates. Open
Understanding the functional impact of bacterial genetic diversity is crucial for linking pathogen variants to clinical outcomes. Here, we introduce a high-throughput cytological profiling pipeline optimized for Mycobacterium tuberculosis …
View article: Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i>
Ribosomal protection as a linezolid resistance mechanism in <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus has emerged as a significant pulmonary pathogen characterized by its resistance to most first-line antimycobacterial drugs. Recent investigations have highlighted the clinical efficacy of including the oxazolidinone…
View article: High-throughput cytological profiling uncovers genotype-phenotype associations in <i>Mycobacterium tuberculosis</i> clinical isolates
High-throughput cytological profiling uncovers genotype-phenotype associations in <i>Mycobacterium tuberculosis</i> clinical isolates Open
Understanding the functional impact of bacterial genetic diversity is crucial for linking pathogen variants to clinical outcomes. Here, we introduce a high-throughput cytological profiling pipeline optimized for Mycobacterium tuberculosis …
View article: The Role of β-Lactam Antibiotics in Treating <i>Mycobacterium abscessus</i> : From Laboratory Insights to Clinical Applications and the Case for Clinical Trials
The Role of β-Lactam Antibiotics in Treating <i>Mycobacterium abscessus</i> : From Laboratory Insights to Clinical Applications and the Case for Clinical Trials Open
Mycobacterium abscessus (Mab) is a highly drug-resistant non-tuberculous mycobacterium that presents major treatment challenges, particularly in individuals with structural lung disease. Although historically considered ineffective, β-lact…
View article: Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis
Structure-Guided Development of a Potent BioA Inhibitor Validates Biotin Synthesis Inhibition as a Therapeutic Strategy for Tuberculosis Open
Structure-guided optimization was applied to develop a potent and selective inhibitor of the aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis. Strategic modifications of a screening hit enhanced potency and pharmacokine…
View article: A transcriptional plasticity-aware framework for RNA-seq differential expression analysis
A transcriptional plasticity-aware framework for RNA-seq differential expression analysis Open
Differential expression (DE) analysis based on transcriptomic data provides a genome-wide assessment of gene responsiveness. We recently characterized transcriptional plasticity (TP)—the variability of gene expression in response to enviro…
View article: RNA polymerase-mediated regulation of intrinsic antibiotic resistance and bacterial cell division
RNA polymerase-mediated regulation of intrinsic antibiotic resistance and bacterial cell division Open
ASBTRACT Rifampin is a frontline antibiotic that inhibits the RNA polymerase of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Unlike most antibiotics, rifampin has an unusual ability to shorten the duration of…
View article: Exploring β-lactam interactions with DacB1: unraveling optimal therapies for combating drug-resistant <i>Mycobacterium tuberculosis</i>
Exploring β-lactam interactions with DacB1: unraveling optimal therapies for combating drug-resistant <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) continues to pose a global public health threat, exacerbated by rising drug-resistant strains of Mycobacterium tuberculosis (Mtb). DacB1, a D,D-carboxypeptidase critical in Mtb peptidoglycan biosynthesis, is a promising t…
View article: Novel C5α-substituted carbapenems enhance <i>Mycobacterium abscessus</i> killing via selective target binding and reduced hydrolysis by Bla <sub>Mab</sub>
Novel C5α-substituted carbapenems enhance <i>Mycobacterium abscessus</i> killing via selective target binding and reduced hydrolysis by Bla <sub>Mab</sub> Open
Mycobacterium abscessus ( Mab ) poses significant clinical challenges and underscores the urgent need for safer and more effective treatments, including β-lactams. Among currently available carbapenems, imipenem is widely used to treat Mab…
View article: Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus
Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus Open
Mycobacterium abscessus is a pulmonary pathogen that exhibits intrinsic resistance to antibiotics, but the factors driving this resistance are incompletely understood. Insufficient intracellular drug accumulation could explain broad-spectr…
View article: Predatory journals: What can we do to protect their prey?
Predatory journals: What can we do to protect their prey? Open
In this Editorial, representatives of the International Committee of Medical Editors discuss the need for multi-stakeholder involvement to recognize and counter the actions of predatory journals.
View article: Activation Mechanism and Structural Assembly of the <i>Mycobacterium tuberculosis</i> ClpP1P2 Protease and Its Associated ATPases
Activation Mechanism and Structural Assembly of the <i>Mycobacterium tuberculosis</i> ClpP1P2 Protease and Its Associated ATPases Open
Supramolecular assemblies are integral to cellular biochemical processes, relying on their dynamic nature to fulfill essential functions. The protease ClpP1P2, paired with ATPase partners ClpC1 or ClpX, is vital for the survival of Mycobac…
View article: Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in <i>Mycobacterium tuberculosis</i>
Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in <i>Mycobacterium tuberculosis</i> Open
In an era of increasing resistance, new and effective strategies are needed for antibiotic discovery. Whole-cell active screens yield candidate compounds lacking mechanism-of-action (MOA) information and thus do not provide biological insi…
View article: P-775. Unlocking Synergistic Potency: Dual Action of β-Lactam and β-Lactamase Inhibitor in Combating <i>Mycobacterium abscessus</i> through β-Lactamase Inhibition and Multi-Target Receptor Inactivation
P-775. Unlocking Synergistic Potency: Dual Action of β-Lactam and β-Lactamase Inhibitor in Combating <i>Mycobacterium abscessus</i> through β-Lactamase Inhibition and Multi-Target Receptor Inactivation Open
Background Mycobacterium abscessus (Mab) poses significant clinical challenges, leading to chronic pulmonary disease in immunocompromised patients. Current treatment involve amikacin (AMK), which is toxic, highlighting the imperative for s…
View article: Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models
Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models Open
Human challenge experiments could accelerate tuberculosis vaccine development. This requires a safe Mycobacterium tuberculosis (Mtb) strain that can both replicate in the host and be reliably cleared. Here we genetically engineered Mtb str…
View article: Transposon-sequencing across multiple <i>Mycobacterium abscessus</i> isolates reveals significant functional genomic diversity among strains
Transposon-sequencing across multiple <i>Mycobacterium abscessus</i> isolates reveals significant functional genomic diversity among strains Open
Mycobacterium abscessus (Mab ) is a clinically significant pathogen and a highly genetically diverse species due to its large accessory genome. The functional consequence of this diversity remains unknown mainly because, to date, functiona…
View article: Durlobactam in combination with β-lactams to combat <i>Mycobacterium abscessus</i>
Durlobactam in combination with β-lactams to combat <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus ( Mab ) presents significant clinical challenges. This study evaluated the synergistic effects of a β-lactam and β-lactamase inhibitor combination against Mab and explored the underlying mechanisms. Synergy was asse…
View article: Deep learning-based prediction of chemical accumulation in a pathogenic mycobacterium
Deep learning-based prediction of chemical accumulation in a pathogenic mycobacterium Open
Drugs must accumulate at their target site to be effective, and inadequate uptake of drugs is a substantial barrier to the design of potent therapies. This is particularly true in the development of antibiotics, as bacteria possess numerou…
View article: Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in<i>Mycobacterium abscessus</i>
Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in<i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus is a pulmonary pathogen that exhibits intrinsic resistance to antibiotics, but the factors driving this resistance are incompletely understood. Insufficient intracellular drug accumulation could explain broad-spectr…
View article: Inflammation unites diverse acute and chronic diseases
Inflammation unites diverse acute and chronic diseases Open
Background Inflammation and immunity contribute pivotally to diverse acute and chronic diseases. Inflammatory pathways have become increasingly targets for therapy. Yet, despite substantial similarity in mechanisms and pathways, the scient…
View article: Reducing the Risks of Nuclear War: The Role of Health Professionals
Reducing the Risks of Nuclear War: The Role of Health Professionals Open
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