Eric Sanders‐Buell
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View article: Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor
Distinct memory CD4 <sup>+</sup> T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor Open
Background Low HIV-1 infection level in the central memory CD4 + T cell subset is a hallmark of both non-progressive HIV infection and non-pathogenetic SIV infection in the natural hosts. However, an important gap in knowledge is whether C…
View article: High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa
High peak viraemia followed by spontaneous HIV‐1 control in women living with HIV‐1 subtype A1 in East Africa Open
Introduction Cases of spontaneous control of HIV‐1 can help define strategies to induce remission. Since the identification of viral control in the absence of treatment typically occurs after a prolonged period post‐HIV‐1 diagnosis, our kn…
View article: SIV monoclonal antibody administration spanning treatment interruption in macaques delays viral rebound and selects escape variants
SIV monoclonal antibody administration spanning treatment interruption in macaques delays viral rebound and selects escape variants Open
HIV-1 envelope broadly neutralizing antibodies represent a promising component of HIV-1 cure strategies. To evaluate the therapeutic efficacy of combination monoclonal antibodies (mAbs) in a rigorous nonhuman primate model, we tested diffe…
View article: Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG
Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG Open
The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudov…
View article: Prevalence of <i>Mycoplasma genitalium</i> Infection and Macrolide and Fluoroquinolone Resistance Mutations Among US Air Force Service Members With HIV, 2016–2020
Prevalence of <i>Mycoplasma genitalium</i> Infection and Macrolide and Fluoroquinolone Resistance Mutations Among US Air Force Service Members With HIV, 2016–2020 Open
Background Mycoplasma genitalium (MG) infection is a public health concern due to antimicrobial resistance (AMR). Data are limited on repeat MG infection and AMR among US Air Force service members with HIV. Methods US Air Force service mem…
View article: Prevalence of<i>Mycoplasma genitalium</i>infection and macrolide and fluoroquinolone resistance mutations among U.S. Air Force service members living with HIV, 2016-2020
Prevalence of<i>Mycoplasma genitalium</i>infection and macrolide and fluoroquinolone resistance mutations among U.S. Air Force service members living with HIV, 2016-2020 Open
Background Mycoplasma genitalium (MG) infection is of public health concern due to antimicrobial resistance (AMR). Data are limited on repeat MG infection and AMR among United States Air Force (USAF) service members (SMs) living with human…
View article: Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States
Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States Open
Subtype B HIV-1 has been the primary driver of the HIV-1 epidemic in the United States (U.S.) for over forty years and is also a prominent subtype in the Americas, Europe, Australia, the Middle East and North Africa. In this study, the neu…
View article: Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study
Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study Open
Institute of Human Virology, National Institutes of Health, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Thai Red Cross AIDS Research Centre, Gilead Sciences, Merck, and ViiV Healthcare.
View article: Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype Open
Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, detection was not at the earliest stages of acute infection. Here, we identified an X4-tropi…
View article: Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo
Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo Open
Host restriction factors play key roles in innate antiviral defense, but it remains poorly understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic analysis to identify host factors associated with HIV-1 c…
View article: Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines Among Sexual and Gender Minorities Living With and Without HIV-1 from Lagos, Nigeria
Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines Among Sexual and Gender Minorities Living With and Without HIV-1 from Lagos, Nigeria Open
Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections have not been sufficiently characterized for sexual and gender minorities (S…
View article: Evolution of Antibody Responses in HIV-1 CRF01_AE Acute Infection: Founder Envelope V1V2 Impacts the Timing and Magnitude of Autologous Neutralizing Antibodies
Evolution of Antibody Responses in HIV-1 CRF01_AE Acute Infection: Founder Envelope V1V2 Impacts the Timing and Magnitude of Autologous Neutralizing Antibodies Open
Development of an effective HIV-1 vaccine will be facilitated by better understanding the dynamics between the founder virus and the early humoral responses. Variations between subtypes may influence the evolution of immune responses and s…
View article: Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting
Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting Open
The CCR5 (R5) to CXCR4 (X4) coreceptor switch in natural HIV-1 infection is associated with faster progression to AIDS, but the underlying mechanisms remain unclear. The difficulty in capturing the earliest moment of coreceptor switch in v…
View article: Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission
Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission Open
Introduction Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. Methods In this stud…
View article: HIV-1 infections with multiple founders associate with the development of neutralization breadth
HIV-1 infections with multiple founders associate with the development of neutralization breadth Open
Eliciting broadly neutralizing antibodies (bnAbs) is a cornerstone of HIV-1 vaccine strategies. Comparing HIV-1 envelope (env) sequences from the first weeks of infection to the breadth of antibody responses observed several years after in…
View article: Limited Evidence for a Relationship between HIV-1 Glycan Shield Features in Early Infection and the Development of Neutralization Breadth
Limited Evidence for a Relationship between HIV-1 Glycan Shield Features in Early Infection and the Development of Neutralization Breadth Open
A major goal of HIV-1 vaccine research is to design vaccine candidates that elicit potent broadly neutralizing antibodies (bNAbs). Different viral features have been associated with the development of bNAbs, including the glycan shield on …
View article: RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection
RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection Open
The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1’s high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the eff…
View article: Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses
Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses Open
[This corrects the article DOI: 10.1371/journal.ppat.1009101.].
View article: Factors influencing estimates of HIV-1 infection timing using BEAST
Factors influencing estimates of HIV-1 infection timing using BEAST Open
While large datasets of HIV-1 sequences are increasingly being generated, many studies rely on a single gene or fragment of the genome and few comparative studies across genes have been done. We performed genome-based and gene-specific Bay…
View article: RV144 HIV-1 vaccination impacts post-infection antibody responses
RV144 HIV-1 vaccination impacts post-infection antibody responses Open
The RV144 vaccine efficacy clinical trial showed a reduction in HIV-1 infections by 31%. Vaccine efficacy was associated with stronger binding antibody responses to the HIV Envelope (Env) V1V2 region, with decreased efficacy as responses w…
View article: Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection Open
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with F…
View article: Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria
Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria Open
Detection of HSIL was low. Although HR-HPV was abundant, HSIL development also depends on the duration of HR-HPV infections and the anoscopist's level of experience. As our cohort ages and the anoscopist becomes more skilled, detection of …
View article: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection
Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection Open
In order to inform the rational design of HIV-1 preventive and cure interventions it is critical to understand the events occurring during acute HIV-1 infection (AHI). Using viral deep sequencing on six participants from the early capture …
View article: Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound
Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound Open
Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutel…