Yusheng Zhang
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View article: Yin-dan-ping-gan Capsule mitigates CCL 4 -induced liver fibrosis via activating PPAR γ/GPX4 signaling and suppressing ferroptosis
Yin-dan-ping-gan Capsule mitigates CCL 4 -induced liver fibrosis via activating PPAR γ/GPX4 signaling and suppressing ferroptosis Open
Background: Liver fibrosis is a major global public health issue that is only getting worse. The underlying molecular mechanisms of Yindanpinggan Capsule (YDPG), a traditional Chinese medication, are still unknown, although it has shown no…
View article: Optimization of Magnetic Finishing Process and Surface Quality Research for Inner Wall of MP35N Cobalt–Chromium Alloy Vascular Stent Tubing Based on Plasma-Fused Al2O3 Magnetic Abrasives
Optimization of Magnetic Finishing Process and Surface Quality Research for Inner Wall of MP35N Cobalt–Chromium Alloy Vascular Stent Tubing Based on Plasma-Fused Al2O3 Magnetic Abrasives Open
To solve the manufacturing problem of the efficient removal of multi-scale surface defects (wrinkles, cracks, scratches, etc.) on the inner wall of MP35N cobalt–chromium alloy vascular stents, this study proposes a collaborative optimizati…
View article: Concentration and source changes of nitrous acid (HONO) during the COVID-19 lockdown in Beijing
Concentration and source changes of nitrous acid (HONO) during the COVID-19 lockdown in Beijing Open
Nitrous acid (HONO) is an important precursor of OH radicals which affects not only the sinks of primary air pollutants but also the formation of secondary air pollutants, but its source closure in the atmosphere is still controversial due…
View article: Supplementary material to "Concentration and source changes of HONO during the COVID-19 lockdown in Beijing"
Supplementary material to "Concentration and source changes of HONO during the COVID-19 lockdown in Beijing" Open
Boundary layer height Ceilometer (CL51) 60 s 50 m 10% Nitrate ToF-ACSM 600 s 0.021 µg m -3 5% Sulfate ToF-ACSM 600 s 0.018 µg m -3 5% Chloride ToF-ACSM 600 s 0.011 µg m -3 5%
View article: Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes
Mild synthesis of ultra-bright carbon dots with solvatochromism for rapid lipid droplet monitoring in varied physiological processes Open
Lipid droplets (LDs) participating in various cellular activities and are increasingly being emphasized. Fluorescence imaging provides powerful tool for dynamic tracking of LDs, however, most current LDs probes remain inconsistent performa…
View article: Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma
Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma Open
Approximately 20% of head and neck squamous cell carcinomas (HNSCCs) exhibit reduced methylation on lysine 36 of histone H3 (H3K36me) due to mutations in histone methylase NSD1 or a lysine-to-methionine mutation in histone H3 (H3K36M). Whe…
View article: Epigenetic mechanisms driving the pathogenesis of systemic lupus erythematosus, systemic sclerosis and dermatomyositis
Epigenetic mechanisms driving the pathogenesis of systemic lupus erythematosus, systemic sclerosis and dermatomyositis Open
Autoimmune connective tissue disorders, including systemic lupus erythematosus, systemic sclerosis (SSc) and dermatomyositis (DM), often manifest with debilitating cutaneous lesions and can result in systemic organ damage that may be life‐…
View article: Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma
Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma Open
Approximately 20% of head and neck squamous cell carcinomas (HNSCC) exhibit reduced methylation on lysine 36 of histone H3 (H3K36me) due to mutations in histone methylase NSD1 or a lysine-to-methionine mutation in histone H3 (H3K36M). Whet…
View article: NTIRE 2023 Quality Assessment of Video Enhancement Challenge
NTIRE 2023 Quality Assessment of Video Enhancement Challenge Open
This paper reports on the NTIRE 2023 Quality Assessment of Video Enhancement Challenge, which will be held in conjunction with the New Trends in Image Restoration and Enhancement Workshop (NTIRE) at CVPR 2023. This challenge is to address …
View article: Mild oxidative stress protects against chemotherapy-induced hair loss
Mild oxidative stress protects against chemotherapy-induced hair loss Open
Chemotherapy induces hair loss in most cancer patients who undergo treatment, which causes them significant psychosocial trauma. Scalp cooling has demonstrated some efficacy in attenuating chemotherapy-induced alopecia, but response rate v…
View article: Dust emission reduction enhanced gas-to-particle conversion of ammonia in the North China Plain
Dust emission reduction enhanced gas-to-particle conversion of ammonia in the North China Plain Open
Ammonium salt is an important component of particulate matter with aerodynamic diameter less than 2.5 µm (PM 2.5 ) and has significant impacts on air quality, climate, and natural ecosystems. However, a fundamental understanding of the con…
View article: TBX1 regulates myogenic differentiation by activating the TGFβ-Smad2/3 pathway in myoblasts
TBX1 regulates myogenic differentiation by activating the TGFβ-Smad2/3 pathway in myoblasts Open
TBX1 is systematically conserved in the T-box transcription factor family and regulates craniofacial muscle development during various stages of myogenesis, including commitment, proliferation, terminal differentiation, and survival. Howev…
View article: Seasonal variation in oxygenated organic molecules in urban Beijing and their contribution to secondary organic aerosol
Seasonal variation in oxygenated organic molecules in urban Beijing and their contribution to secondary organic aerosol Open
Oxygenated organic molecules (OOMs) are crucial for atmospheric new particle formation and secondary organic aerosol (SOA) growth. Therefore, understanding their chemical composition, temporal behavior, and sources is of great importance. …
View article: Epimedin C Alleviates Glucocorticoid-Induced Suppression of Osteogenic Differentiation by Modulating PI3K/AKT/RUNX2 Signaling Pathway
Epimedin C Alleviates Glucocorticoid-Induced Suppression of Osteogenic Differentiation by Modulating PI3K/AKT/RUNX2 Signaling Pathway Open
Secondary osteoporosis is triggered mostly by glucocorticoid (GC) therapy. Dexamethasone (DEX) was reported to inhibit osteogenic differentiation in zebrafish larvae and MC3T3-E1 cells in prior research. In this research, we primarily exam…
View article: Population pharmacokinetics of polymyxin B and dosage strategy in critically ill patients with/without continuous renal replacement therapy
Population pharmacokinetics of polymyxin B and dosage strategy in critically ill patients with/without continuous renal replacement therapy Open
Polymyxin B is served as a last-line agent for Carbapenem-resistant organisms (CRO) infections. This study aimed to establish a population pharmacokinetic (PK) model in patients with/without continuous renal replacement therapy (CRRT), to …
View article: Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways
Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Open
Androgenetic alopecia (“AGA”) is the most prevalent type of progressive hair loss, causing tremendous psychological and social stress in patients. However, AGA treatment remains limited in scope. The pathogenesis of androgenetic alopecia i…
View article: CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke Open
Background: Acute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Prediction of penumbra existence after AIS is crucial for making decision on reperfusion therapy. Yet a fast, inexpensive, simple, and noninv…
View article: Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly
Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly Open
In this study, we explored the precise mechanisms underlying the receptor for advanced glycation end products (RAGE)‐mediated neuronal loss and behavioral dysfunction induced by hyperglycemia. We used immunoprecipitation (IP) and GST pull‐…
View article: Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke
Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke Open
Ischemic stroke (IS) is a multifactorial disease caused by the interaction of multiple environmental and genetic risk factors, and it is the most common cause of disability. The immune microenvironment and inflammatory response participate…
View article: Ammonium nitrate promotes sulfate formation through uptake kinetic regime
Ammonium nitrate promotes sulfate formation through uptake kinetic regime Open
Although the anthropogenic emissions of SO2 have decreased significantly in China, the decrease in SO42- in PM2.5 is much smaller than that of SO2. This implies an enhanced formation rate of SO42- in the ambient air, and the mechanism is s…
View article: The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation
The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation Open
Polycomb complexes have traditionally been prescribed roles as transcriptional repressors, though increasing evidence demonstrate they can also activate gene expression. However, the mechanisms underlying positive gene regulation mediated …
View article: Comment on acp-2021-289
Comment on acp-2021-289 Open
Abstract. Although the anthropogenic emissions of SO2 have decreased significantly in China, the decrease in SO42- in PM2.5 is much smaller than that of SO2. This implies an enhanced formation rate of SO42- in the ambient air, and the mech…
View article: Ammonium nitrate promotes sulfate formation through uptake kinetic regime
Ammonium nitrate promotes sulfate formation through uptake kinetic regime Open
Although the anthropogenic emissions of SO2 have decreased significantly in China, the decrease in SO42− in PM2.5 is much smaller than that of SO2. This implies an enhanced formation rate of SO42− in the ambient air, and the mechanism is s…
View article: Epigenetic mechanisms in breast cancer therapy and resistance
Epigenetic mechanisms in breast cancer therapy and resistance Open
The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent the main treatment modality. Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since …
View article: Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation
Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation Open
Ischemic cerebral infarction represents a significant cause of disability and death worldwide. Caspase-1 is activated by the NLRP3/ASC pathway and inflammasomes, thus triggering pyroptosis, a programmed cell death. In particular, this deat…
View article: Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway
Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway Open
Parkinson's disease (PD) is a common neurodegenerative disease with global health and economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction and oxidative stress are reported to participate in the pathologica…