Eric J. Simon
YOU?
Author Swipe
View article: Approaching the holistic transcriptome—convolution and deconvolution in transcriptomics
Approaching the holistic transcriptome—convolution and deconvolution in transcriptomics Open
Tissues, organs, and entire organisms are composed of diverse cell populations, which are characterized by cell-type-specific gene activities. Bulk RNA-seq represents a robust, cost-effective, scalable method to measure gene activity at th…
View article: Single-cell landscape of peripheral immune cells in MASLD/MASH
Single-cell landscape of peripheral immune cells in MASLD/MASH Open
Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) progresses to metabolic dysfunction–associated steatohepatitis (MASH) and is a major cause of liver cirrhosis. Although liver inflammation is the hallmark feature…
View article: PPDPF is not a key regulator of human pancreas development
PPDPF is not a key regulator of human pancreas development Open
Given their capability to differentiate into each cell type of the human body, human pluripotent stem cells (hPSCs) provide a unique platform for developmental studies. In the current study, we employed this cell system to understand the r…
View article: Opioid receptors in GtoPdb v.2025.1
Opioid receptors in GtoPdb v.2025.1 Open
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn)…
View article: Diverse potential of secretome from natural killer cells and monocyte-derived macrophages in activating stellate cells
Diverse potential of secretome from natural killer cells and monocyte-derived macrophages in activating stellate cells Open
Chronic liver diseases, such as non-alcoholic steatohepatitis (NASH)-induced cirrhosis, are characterized by an increasing accumulation of stressed, damaged, or dying hepatocytes. Hepatocyte damage triggers the activation of resident immun…
View article: An optimized protocol for isolation of hepatic leukocytes retrieved from murine and NASH liver biopsies
An optimized protocol for isolation of hepatic leukocytes retrieved from murine and NASH liver biopsies Open
Immune dysregulation and inflammation by hepatic-resident leukocytes is considered a key step in disease progression of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis toward cirrhosis and hepatocellular carcinoma. Here…
View article: Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension Open
Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and r…
View article: Opioid receptors in GtoPdb v.2023.1
Opioid receptors in GtoPdb v.2023.1 Open
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn)…
View article: Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes
Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes Open
Retinopathies are multifactorial diseases with complex pathologies that eventually lead to vision loss. Animal models facilitate the understanding of the pathophysiology and identification of novel treatment options. However, each animal m…
View article: BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy Open
BI 456906 is a potent GCGR/GLP-1R dual agonist with robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
View article: Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH
Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet‐induced obese and biopsy‐confirmed mouse model of NASH Open
Non‐alcoholic steatohepatitis (NASH) has emerged as a major challenge for public health because of high global prevalence and lack of evidence‐based therapies. Most animal models of NASH lack sufficient validation regarding disease progres…
View article: Controlling the Correctness of Aggregation Operations During Sessions of Interactive Analytic Queries
Controlling the Correctness of Aggregation Operations During Sessions of Interactive Analytic Queries Open
We present a comprehensive set of conditions and rules to control the correctness of aggregation queries within an interactive data analysis session. The goal is to extend self-service data preparation and BI tools to automatically detect …
View article: Deep Learning-based Signal Detection for Uplink in LoRa-like Networks
Deep Learning-based Signal Detection for Uplink in LoRa-like Networks Open
The increasing number of devices together with uncoordinated transmissions result in a major challenge of scalability in the Internet of things. This paper deals with signal detection in the uplink of a LoRa network through a deep learning…
View article: Opioid receptors in GtoPdb v.2021.3
Opioid receptors in GtoPdb v.2021.3 Open
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn)…
View article: Elevated β-cell stress levels promote severe diabetes development in mice with MODY4
Elevated β-cell stress levels promote severe diabetes development in mice with MODY4 Open
Maturity-onset diabetes of the young (MODY) is a group of monogenetic forms of diabetes mellitus caused by mutations in genes regulating β-cell development and function. MODY represents a heterogeneous group of non-insulin-dependent diabet…
View article: Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Opioid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Open
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn)…