Navneet Singh
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View article: Sorption dynamics of six per- and polyfluoroalkyl substances in estuarine sediments: The role of particle size distribution and salinity in low organic carbon sediments
Sorption dynamics of six per- and polyfluoroalkyl substances in estuarine sediments: The role of particle size distribution and salinity in low organic carbon sediments Open
Per- and polyfluoroalkyl substances (PFAS) are a family of synthetic organofluorine compounds; many are widespread environmental contaminants. Estuarine sediments can serve as both long-term sinks, and secondary sources for PFAS, by potent…
View article: Isolated Pulmonary IgG4-related Disease Presenting as Cavitary Lung Lesions and Mass Formation, Treated with Rituximab Monotherapy
Isolated Pulmonary IgG4-related Disease Presenting as Cavitary Lung Lesions and Mass Formation, Treated with Rituximab Monotherapy Open
View article: Exploring the Therapeutic Landscape of <i>Sorbaria tomentosa</i>: A Phytochemical and Pharmacological Perspective
Exploring the Therapeutic Landscape of <i>Sorbaria tomentosa</i>: A Phytochemical and Pharmacological Perspective Open
Sorbaria tomentosa, commonly known as the Himalayan Sorbaria, is a deciduous wild perennial shrub belonging to the Rosaceae family. It has long been used in herbal treatments in many regions of Asia for its potential therapeutic benefits. …
View article: Liquid biopsy in hepatobiliary and pancreatic cancers: A paradigm shift in early detection, prognostic stratification, and perioperative monitoring
Liquid biopsy in hepatobiliary and pancreatic cancers: A paradigm shift in early detection, prognostic stratification, and perioperative monitoring Open
BACKGROUND Hepatobiliary and pancreatic cancers are among the most lethal malignancies due to late-stage diagnosis and limited treatment options. Liquid biopsy has emerged as a minimally invasive tool for early cancer detection, prognosis,…
View article: Cardiac dysfunction in transfusion‐dependent β‐thalassaemia: Insights into <i>apolipoprotein E</i> genotypes and iron metrics in a north Indian cohort
Cardiac dysfunction in transfusion‐dependent β‐thalassaemia: Insights into <i>apolipoprotein E</i> genotypes and iron metrics in a north Indian cohort Open
View article: 153P Predictors of resistance to single-agent chemotherapy in low-risk gestational trophoblastic neoplasia with FIGO score 5-6
153P Predictors of resistance to single-agent chemotherapy in low-risk gestational trophoblastic neoplasia with FIGO score 5-6 Open
View article: 152P Pregnancy after gestational trophoblastic neoplasia: Navigating fertility post-chemotherapy
152P Pregnancy after gestational trophoblastic neoplasia: Navigating fertility post-chemotherapy Open
View article: Role of salivary Insulin-like Growth Factor-1 (IGF-1) in the regulation of biomechanical process following mandibular advancement with a twin block appliance-a prospective observational study
Role of salivary Insulin-like Growth Factor-1 (IGF-1) in the regulation of biomechanical process following mandibular advancement with a twin block appliance-a prospective observational study Open
View article: Clinical Outcomes and Success Factors of Pterygoid Implants in the Posterior Atrophic Maxilla: A Prospective Study
Clinical Outcomes and Success Factors of Pterygoid Implants in the Posterior Atrophic Maxilla: A Prospective Study Open
Introduction Pterygoid implants serve as an alternative for rehabilitating a posterior atrophic maxilla without requiring extensive bone grafting or sinus augmentation. This study aimed to evaluate the clinical outcomes and success rates o…
View article: Comparative Assessment of Clinical Outcomes in Flapless and Flapped Implant Surgical Techniques: A Prospective Cohort Study
Comparative Assessment of Clinical Outcomes in Flapless and Flapped Implant Surgical Techniques: A Prospective Cohort Study Open
Flapless implant placement was associated with significantly lower postoperative pain and more favorable soft tissue healing with reduced PD at six months than the flap technique. However, both approaches demonstrated comparable changes in…
View article: Concentrations of per- and polyfluoroalkyl substances in estuarine systems can vary greatly within tidal cycles
Concentrations of per- and polyfluoroalkyl substances in estuarine systems can vary greatly within tidal cycles Open
Per and poly-fluoroalkyl substances are currently of concern due to their widespread occurrence, resistance to degradation and potential toxicity. Major efforts are underway worldwide to assess environmental concentrations of PFAS, but mos…
View article: Film Review of 'Margarita with a Straw'- Exploration of Sexuality by a Woman with Disability
Film Review of 'Margarita with a Straw'- Exploration of Sexuality by a Woman with Disability Open
Cinema is a tool for positive social change within social work. It is a powerful tool for challenging deeply rooted social stereotypes in society. Cinema would provide a robust and in-depth portrayal of the lives of women with disabilities…
View article: An Endobronchial Aspergilloma Concealing Metastatic Renal Cell Carcinoma of the Bronchus: A Case Report
An Endobronchial Aspergilloma Concealing Metastatic Renal Cell Carcinoma of the Bronchus: A Case Report Open
View article: 645. Rapid Versus Conservative Tuberculosis De-isolation Policy Impact Assessment: Province-wide Retrospective Review of 2017-2020, British Columbia, Canada
645. Rapid Versus Conservative Tuberculosis De-isolation Policy Impact Assessment: Province-wide Retrospective Review of 2017-2020, British Columbia, Canada Open
Background Tuberculosis (TB) remains a significant global health threat. Upon diagnosis, patients with pulmonary TB are required to undergo specific isolation precautions to prevent further disease transmission. Current practice typically …
View article: Hydroxycitrate-loaded exosomes demonstrate enhanced therapeutic efficacy against lung adenocarcinoma by inhibiting the metabolic enzyme ATP citrate lyase
Hydroxycitrate-loaded exosomes demonstrate enhanced therapeutic efficacy against lung adenocarcinoma by inhibiting the metabolic enzyme ATP citrate lyase Open
Exosomes isolated from bovine milk were loaded with potassium hydroxycitrate and surface-conjugated with folate. This formulation (Exo-KH) exhibited high loading efficiency, sustained drug release, and enhanced therapeutic efficacy in vivo…
View article: Adult pleuropulmonary blastoma: Report of two cases of an extremely rare entity
Adult pleuropulmonary blastoma: Report of two cases of an extremely rare entity Open
The uncommon malignant dysontogenetic neoplasm known as pleuropulmonary blastoma (PPB) typically affects children. It forms a part of the pulmonary sarcomatoid carcinoma family and is frequently distinguished by a biphasic form with both m…
View article: Toxicity of the organic UV filter oxybenzone to the brown macroalga Hormosira banksii and the green macroalga Ulva lactuca
Toxicity of the organic UV filter oxybenzone to the brown macroalga Hormosira banksii and the green macroalga Ulva lactuca Open
Oxybenzone (BP-3), a common sunscreen ingredient, has been detected in marine ecosystems and shown to be toxic to various marine species, raising environmental concerns. However, its effects on macroalgae remain largely unknown. This study…
View article: A Case of Mediastinal Lymphoma that was Missed on EBUS-TBNA but Correctly Diagnosed after EBUS-TBCNB
A Case of Mediastinal Lymphoma that was Missed on EBUS-TBNA but Correctly Diagnosed after EBUS-TBCNB Open
View article: Malignant pleural mesothelioma: The disdained member of thoracic oncology!
Malignant pleural mesothelioma: The disdained member of thoracic oncology! Open
Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos exposure. The ban on asbestos has helped to lower the incidence, but in developing countries…
View article: Computed Tomography Spectrum of Complications in Usual Interstitial Pneumonia Pattern in a Tertiary Care Hospital: A Descriptive Cross- sectional Study
Computed Tomography Spectrum of Complications in Usual Interstitial Pneumonia Pattern in a Tertiary Care Hospital: A Descriptive Cross- sectional Study Open
Introduction: Idiopathic pulmonary fibrosis is the most prevalent form of interstitial lung disease, which presents as usual interstitial pneumonia on histopathology and imaging. It leads to significant lung scarring, damage, and fibrosis …
View article: Lung cancer in Asia: the impact of climate change
Lung cancer in Asia: the impact of climate change Open
The escalating global threat of climate change is becoming more evident. The climate crisis intersects with another major challenge: lung cancer. With Asia already bearing half the global cancer burden, the impact of climate-related events…
View article: Exposure to PFAS contaminated urban wetland water causes similar metabolic alterations to laboratory-based exposures in the freshwater amphipod Austrochiltonia subtenuis
Exposure to PFAS contaminated urban wetland water causes similar metabolic alterations to laboratory-based exposures in the freshwater amphipod Austrochiltonia subtenuis Open
Assessing the harm caused by pollutants in urban ecosystems remains a significant challenge. Traditional ecotoxicological endpoints are often not sensitive enough to detect the effects of toxicants at environmentally relevant concentration…
View article: segcsvd<sub>WMH</sub>: A convolutional neural network-based tool for quantifying white matter hyperintensities in heterogeneous patient cohorts
segcsvd<sub>WMH</sub>: A convolutional neural network-based tool for quantifying white matter hyperintensities in heterogeneous patient cohorts Open
White matter hyperintensities (WMH) of presumed vascular origin are an MRI-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with accelerated cognitive decline and increased risk of stroke and dementia, and are co…
View article: HGG-29. INTEGRATED MOLECULAR PROFILING OF &gt;2000 PAEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA TUMOURS AND &gt;100 PATIENT-DERIVED MODELS
HGG-29. INTEGRATED MOLECULAR PROFILING OF >2000 PAEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMA TUMOURS AND >100 PATIENT-DERIVED MODELS Open
BACKGROUND Paediatric-type diffuse high-grade glioma (PDHGG) is recognised in the WHO2021 CNS Tumour Classification as biologically distinct from ‘adult-types’, and comprises four major categories based on distinct biology and clinical pre…
View article: Cancer Trials Ecosystem in India—Ready for Prime Time?
Cancer Trials Ecosystem in India—Ready for Prime Time? Open
Executing global clinical trials for cancer is a long, expensive, and complex undertaking. While selecting countries global studies, sponsors must consider several aspects including patient pool, quality of trained investigators, competing…
View article: Charting the Course of Targeted α Therapy With First-in-Human, Postadministration Image-Guided Dosimetry and Response Assessment of 212Pb-VMT-α-NET in Metastatic Neuroendocrine Tumors
Charting the Course of Targeted α Therapy With First-in-Human, Postadministration Image-Guided Dosimetry and Response Assessment of 212Pb-VMT-α-NET in Metastatic Neuroendocrine Tumors Open
212 Pb emerges as a compelling in vivo α-particle generator for targeted α therapy due to its favorable half-life ( t 1/2 = 10.6 hours) aligning with the biological half-lives of small peptides and its potent α-particle emissions within th…
View article: Assessing the impact of immobilisation on the bioavailability of PFAS to plants in contaminated Australian soils
Assessing the impact of immobilisation on the bioavailability of PFAS to plants in contaminated Australian soils Open
Per- and polyfluoroalkyl substances (PFAS) have become a key concern to both environmental and human health due to their extreme persistence in the environment and their ability to bioaccumulate in plants, animals, and humans. In this meso…
View article: The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the M Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer
The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the M Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer Open
View article: Economic Evaluation of Targeted Therapies for Anaplastic Lymphoma Kinase– and ROS1 Fusion–Positive Non–Small Cell Lung Cancer in India
Economic Evaluation of Targeted Therapies for Anaplastic Lymphoma Kinase– and ROS1 Fusion–Positive Non–Small Cell Lung Cancer in India Open
PURPOSE Targeted therapies, such as crizotinib and ceritinib, have shown promising results in treating non–small cell lung cancer (NSCLC) with specific oncogenic drivers like anaplastic lymphoma kinase ( ALK), c-ros ( ROS1) oncogene, etc. …
View article: Association between genetic polymorphisms in SLC19A1, SLCO1B1 and SLCO1B3 genes predicts survival and toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy
Association between genetic polymorphisms in SLC19A1, SLCO1B1 and SLCO1B3 genes predicts survival and toxicity in North Indian lung cancer patients undergoing platinum-based doublet chemotherapy Open
Aims: SLC transporters are expressed in lungs and are essential membrane proteins responsible for the transport of wide range of chemotherapeutic drugs. Polymorphisms in SLC19A1, SLCO1B1, and SLCO1B3 gene in North Indian lung cancer patien…