Eric Steinberg
YOU?
Author Swipe
View article: Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post‐traumatic Alzheimer's disease and related dementias
Boston University Alzheimer's Disease Research Center Clinical Core: Infrastructure to facilitate research on post‐traumatic Alzheimer's disease and related dementias Open
We describe the rationale, methodology, and design of the Boston University Alzheimer's Disease Research Center (BU ADRC) Clinical Core (CC). The CC characterizes a longitudinal cohort of participants with/without brain trauma to character…
View article: Unique Pattern of White Matter Hyperintensities in Middle Age and Older Adults with History of Repetitive Head Impact Exposure
Unique Pattern of White Matter Hyperintensities in Middle Age and Older Adults with History of Repetitive Head Impact Exposure Open
Background Repetitive head impacts (RHI) from contact sports can lead to long‐term white matter injury visualized on FLAIR scans as white matter hyperintensities (WMH). The goal of this study was to preliminarily characterize the unique pa…
View article: Cased-Based Imaging Curriculum: Filling an Educa
Cased-Based Imaging Curriculum: Filling an Educa Open
versus "stable"; 3) recognize the "EM Mindset", including initial stabilization/workup and "worst-first" mentality.Curricular Design: Using Kern's model, our team of expert faculty refined topics in the CDEM Curriculum, established module …
View article: Teaching residents to teach: A pilot study for an innovative online curriculum
Teaching residents to teach: A pilot study for an innovative online curriculum Open
Introduction Resident‐as‐teacher (RAT) curricula have improved teaching behavior, ability, and confidence among resident participants. However, there are limited data on the appropriate format, length, and content. With teaching being a co…
View article: Optimal blood tau species for the detection of Alzheimer’s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study
Optimal blood tau species for the detection of Alzheimer’s disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study Open
Plasma-to-autopsy studies are essential for validation of blood biomarkers and understanding their relation to Alzheimer’s disease (AD) pathology. Few such studies have been done on phosphorylated tau (p-tau) and those that exist have made…
View article: Identifying Optimal Blood Tau Epitopes for the Detection of Alzheimer’s Disease Neuropathology: An Immunoprecipitation Mass Spectrometry and Autopsy Study
Identifying Optimal Blood Tau Epitopes for the Detection of Alzheimer’s Disease Neuropathology: An Immunoprecipitation Mass Spectrometry and Autopsy Study Open
Background Plasma‐to‐autopsy studies are essential for validation of plasma biomarkers for the detection of Alzheimer’s disease (AD). Few such studies have been done and those that exist have had limited or no comparison of the different t…
View article: 5 Antemortem Plasma GFAP Predicts Alzheimer’s Disease Neuropathological Changes
5 Antemortem Plasma GFAP Predicts Alzheimer’s Disease Neuropathological Changes Open
Objective: Blood-based biomarkers offer a more feasible alternative to Alzheimer’s disease (AD) detection, management, and study of disease mechanisms than current in vivo measures. Given their novelty, these plasma biomarkers must be asse…
View article: 4 Evaluating Plasma GFAP for the Detection of Alzheimer’s Disease Dementia
4 Evaluating Plasma GFAP for the Detection of Alzheimer’s Disease Dementia Open
Objective: Blood-based biomarkers represent a scalable and accessible approach for the detection and monitoring of Alzheimer’s disease (AD). Plasma phosphorylated tau (p-tau) and neurofilament light (NfL) are validated biomarkers for the d…
View article: Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease
Cross‐sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease Open
Introduction This study examined plasma glial fibrillary acidic protein (GFAP) as a biomarker of cognitive impairment due to Alzheimer's disease (AD) with and against plasma neurofilament light chain (NfL), and phosphorylated tau (p‐tau) 1…
View article: Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy Open
Blood-based biomarkers such as tau phosphorylated at threonine 181 (phosphorylated-tau181) represent an accessible, cost-effective and scalable approach for the in vivo detection of Alzheimer’s disease pathophysiology. Plasma-pathological …
View article: Plasma p‐tau<sub>181</sub> shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau
Plasma p‐tau<sub>181</sub> shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau Open
Introduction We examined the ability of plasma hyperphosphorylated tau (p‐tau) 181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t‐tau) and neurofilament light (NfL).…
View article: Long‐term effects of repetitive head impacts on gray matter cortical thickness
Long‐term effects of repetitive head impacts on gray matter cortical thickness Open
Background Repetitive head impact (RHI) exposure has been associated with the neurodegenerative disease chronic traumatic encephalopathy (CTE). Magnetic resonance imaging (MRI) and postmortem research suggest frontotemporal atrophy may be …
View article: Quantitative susceptibility mapping MRI reveals a relationship between iron accumulation, CDR score and cognition across the spectrum from healthy aging to Alzheimer’s disease
Quantitative susceptibility mapping MRI reveals a relationship between iron accumulation, CDR score and cognition across the spectrum from healthy aging to Alzheimer’s disease Open
Background The objective of this study was to determine if there is a relationship between iron accumulation in the various white and gray matter regions of the brain, as assessed by susceptibility changes, measured with Quantitative Susce…
View article: Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures
Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures Open
Background: The Framingham Stroke Risk Profile (FSRP) was created in 1991 to estimate 10-year risk of stroke. It was revised in 2017 (rFSRP) to reflect the modern data on vascular risk factors and stroke risk. Objective: This study examine…
View article: Supplementing Fe Exam Results For Continuous Assessment
Supplementing Fe Exam Results For Continuous Assessment Open
Concurrent with the development of specific program outcomes for ABET review, it is necessary to identify assessment vehicles for each stated outcome.One attractive assessment characteristic is the ability to compare student performance fr…
View article: Residency Leadership Lessons From the Epicenter of the COVID‐19 Surge
Residency Leadership Lessons From the Epicenter of the COVID‐19 Surge Open
Emergency medicine residency program directors (PDs) in areas hit hardest by the initial U.S. COVID‐19 pandemic surge faced novel and rapidly evolving organizational, educational, and resident wellness challenges. Despite variations in res…
View article: Assessment of Emergency Medicine Residents’ Clinical Reasoning: Validation of a Script Concordance Test
Assessment of Emergency Medicine Residents’ Clinical Reasoning: Validation of a Script Concordance Test Open
INTRODUCTION: A primary aim of residency training is to develop competence in clinical reasoning. However, there are few instruments that can accurately, reliably, and efficiently assess residents’ clinical decision-making ability. This st…
View article: In Young Adults with COVID-19, Obesity Is Associated with Adverse Outcomes
In Young Adults with COVID-19, Obesity Is Associated with Adverse Outcomes Open
Obesity appears to be an independent risk factor for poor outcomes in young patients with COVID-19. Future studies examining the clinical characteristics and risk factors of COVID-19 patients across large, diverse populations will strength…
View article: Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes
Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes Open
The goal of this study was to examine whether hippocampal volume or resting-state functional connectivity (rsFC) patterns are associated with subjective memory decline (SMD) in cognitively normal aged adults. Magnetic resonance imaging dat…
View article: Five Tips for Building a Successful Didactic Talk
Five Tips for Building a Successful Didactic Talk Open
Despite recent interest in varied teaching modalities, the didactic lecture remains a staple of emergency medicine education.1 Preparing and delivering a memorable didactic talk is no easy task. Whether you are speaking in front of a handf…
View article: Failure to detect an association between self‐reported traumatic brain injury and Alzheimer's disease neuropathology and dementia
Failure to detect an association between self‐reported traumatic brain injury and Alzheimer's disease neuropathology and dementia Open
Introduction Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Alzheimer's Coordinating Center to examine t…
View article: EXPANDING THE GERIATRIC MENTAL HEALTH WORKFORCE TO INCLUDE AGING NETWORK STAFF USING ONLINE TRAINING; HEALTHY IDEAS
EXPANDING THE GERIATRIC MENTAL HEALTH WORKFORCE TO INCLUDE AGING NETWORK STAFF USING ONLINE TRAINING; HEALTHY IDEAS Open
Background: Healthy IDEAS (HI) an evidence-based, novel model of care implemented in 26 states, significantly improves depressive symptoms using non-clinical staff. HI is endorsed by the Centers for Disease Control and National Council on …
View article: P3‐357: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS
P3‐357: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS Open
Aged cognitively normal individuals with subjective memory complaints are more likely to develop objective cognitive impairment than their counterparts without complaints. The goals of this study were to (1) investigate whether differences…
View article: IC‐P‐174: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS
IC‐P‐174: HIPPOCAMPAL VOLUME AND FUNCTIONAL CONNECTIVITY DIFFERENTIATE BETWEEN COGNITIVELY NORMAL INDIVIDUALS WITH AND WITHOUT SUBJECTIVE MEMORY COMPLAINTS Open
Aged cognitively normal individuals with subjective memory complaints are more likely to develop objective cognitive impairment than their counterparts without complaints. The goals of this study were to (1) investigate whether differences…
View article: Neuropsychiatric Symptoms and the Diagnostic Stability of Mild Cognitive Impairment
Neuropsychiatric Symptoms and the Diagnostic Stability of Mild Cognitive Impairment Open
Background: Mild cognitive impairment (MCI) is an intermediate diagnosis between normal cognition (NC) and dementia, including Alzheimer’s disease (AD) dementia. However, MCI is heterogeneous; many individuals subsequently revert to NC whi…