Explanipedia

Supplementary files from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Biology

Extended methods, supplementary figures and supplementary tables.

Data S2 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Biology

Processed data for S222A+ and S222A- cells by RNA and ATAC sequencing

Data S1 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine

Table of phosphopeptides identified in a screen for primary induction failure compared to complete remission AML

Data S4 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Biology

Processed data for MRT199665 and DMSO treated OCI-AML2 cells by RNA sequencing

Data S4 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Biology

Processed data for MRT199665 and DMSO treated OCI-AML2 cells by RNA sequencing

Data S3 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine

Table of results for recombinant protein kinase screen for pS222 MEF2C

Data from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Business Biology

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. Using functional proteomics of patient AML specimens, we identified MEF2C S222 phosphorylation as a specific marker of primary chemoresistanc…

Data S2 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Biology

Processed data for S222A+ and S222A- cells by RNA and ATAC sequencing

Data S1 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine Chemistry

Table of phosphopeptides identified in a screen for primary induction failure compared to complete remission AML

Data from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. Using functional proteomics of patient AML specimens, we identified MEF2C S222 phosphorylation as a specific marker of primary chemoresistanc…

Supplementary files from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine

Extended methods, supplementary figures and supplementary tables.

Data S3 from MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2023

Medicine

Table of results for recombinant protein kinase screen for pS222 MEF2C

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia Open

Fiona C. Brown, Eric Still, Richard P. Koche, Christina Y. Yim, Sumiko Takao , et al. · 2018

Medicine Biology

In acute myeloid leukemia (AML), chemotherapy resistance remains prevalent and poorly understood. Using functional proteomics of patient AML specimens, we identified MEF2C S222 phosphorylation as a specific marker of primary chemoresistanc…

Peptidomimetic blockade of MYB in acute myeloid leukemia Open

Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona C. Brown , et al. · 2018

Biology

Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemia…

Peptidomimetic blockade of MYB in acute myeloid leukemia Open

Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona C. Brown , et al. · 2017

Biology

Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, largely due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activat…

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors Open

Anton G. Henssen, Richard P. Koche, Jiali Zhuang, Eileen Jiang, Casie Reed , et al. · 2017

Biology

Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the piggyBac transposable element derived 5 ( PGBD5 ) gene as an enzymatically active human DNA transp…

MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia Open

Fiona C. Brown, Eric Still, Paolo Cifani, Sumiko Takao, Casie Reed , et al. · 2017

Biology

HIGHLIGHTS MEF2C S222 phosphorylation is a specific marker of chemotherapy resistance in diagnostic AML patient specimens. MEF2C S222 phosphorylation is dispensable for normal hematopoiesis in mice, as established using genome editing in v…

Data S1. Human Pgbd5 Dna Transposase Promotes Site-Specific Oncogenic Mutations In Rhabdoid Tumors Open

Anton G. Henssen, Richard P. Koche, Jiali Zhuang, Eileen Jiang, Casie Reed , et al. · 2016

Biology

Supplementary data S1 for Henssen et al. " Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors"

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia Open

Fiona C. Brown, Paolo Cifani, Esther Drill, Jie He, Eric Still , et al. · 2016

Medicine Biology

Summary Cure rates of children and adults with acute myeloid leukaemia ( AML ) remain unsatisfactory partly due to chemotherapy resistance. We investigated the genetic basis of AML in 107 primary cases by sequencing 670 genes mutated in ha…

Genomics of primary chemoresistance and remission induction failure in pediatric and adult acute myeloid leukemia Open

Fiona C. Brown, Paolo Cifani, Esther Drill, Jie He, Eric Still , et al. · 2016

Medicine Biology

Despite intense efforts, the cure rates of children and adults with AML remain unsatisfactory in large part due to resistance to chemotherapy. Whilst cytogenetic risk stratification proved valuable in identifying causes of therapy failure …

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