Eric T. Monson
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View article: Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality
Genetic Liabilities to Neuropsychiatric Conditions in Suicide Deaths With No Prior Suicidality Open
Importance Although suicide attempt is the most robust estimator of suicide death, few individuals who attempt it go on to die by suicide (<10%), and approximately 50% of suicide deaths occur in the absence of evidence of prior atte…
View article: Defining and assessing international classification of disease suicidality phenotypes for genetic studies
Defining and assessing international classification of disease suicidality phenotypes for genetic studies Open
Lists of applicable ICD codes for SI and SA were developed that complied with C-SSRS definitions. Real-world application of ICD codes can vary substantially, perhaps dependent on clinician training and on cohort characteristics. Consistent…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
View article: Different genetic liabilities to neuropsychiatric conditions in suicides with no prior suicidality
Different genetic liabilities to neuropsychiatric conditions in suicides with no prior suicidality Open
Importance. Though suicide attempt is the most robust predictor of suicide death, few who attempt go on to die by suicide (<10%), and ∼50% of all suicide deaths occur in the absence of evidence of prior attempts. Risks in this latter group…
View article: Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group Open
Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overl…
View article: Intragenic deletions from whole genome sequencing of 1054 suicide deaths
Intragenic deletions from whole genome sequencing of 1054 suicide deaths Open
Suicide is an urgent public health crisis that claimed over 48,000 lives in the US in 2022. The importance of genetics in suicide risk has been established by classical twin and family studies, and confirmed with recent large genome-wide a…
View article: Absence of nonfatal suicidal behavior preceding suicide death reveals differences in clinical risks
Absence of nonfatal suicidal behavior preceding suicide death reveals differences in clinical risks Open
View article: Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses
Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses Open
Results identified multiple clinical comorbidities with chronic pain that differentiate suicide deaths from living control individuals with a history of diagnosed chronic pain. Our findings may help discern individuals with chronic pain wh…
View article: Diagnostic profiles among suicide decedents with and without borderline personality disorder
Diagnostic profiles among suicide decedents with and without borderline personality disorder Open
Background Borderline personality disorder (BPD) is a debilitating condition characterized by pervasive instability across multiple major domains of functioning. The majority of persons with BPD engage in self-injury and up to 10% die by s…
View article: Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies
Defining and Assessing International Classification of Disease Suicidality Phenotypes for Genetic Studies Open
Background Suicidality, including suicidal ideation (SI), attempt (SA), and death (SD), represents complex and partially overlapping phenotypes. This complexity contributes to study population heterogeneity in suicidality research, impedin…
View article: Absence of nonfatal suicidal behavior preceding suicide death reveals differences in clinical risks
Absence of nonfatal suicidal behavior preceding suicide death reveals differences in clinical risks Open
Nonfatal suicidality is the most robust predictor of suicide death. However, only ∼10% of those who survive an attempt go on to die by suicide. Moreover, ∼50% of suicide deaths occur in the absence of prior known attempts, suggesting risks…
View article: The Utah psychotropic oversight program: collaboratively addressing antipsychotic use within youth in foster care without prior authorization
The Utah psychotropic oversight program: collaboratively addressing antipsychotic use within youth in foster care without prior authorization Open
Objectives Fostered youth have increased risk of exposure to trauma. Antipsychotic medications are often utilized within the foster care system, potentially to address problematic behaviors that may be associated with trauma. The Utah Psyc…
View article: GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors Open
This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated wi…
View article: Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes
Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes Open
View article: Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies – a commentary on Lannoy et al. (2022)
Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies – a commentary on Lannoy et al. (2022) Open
Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene–environment interactions across …
View article: Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors
Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors Open
Objective Suicidal behavior is heritable and a major cause of death worldwide. Two large-scale genome-wide association studies (GWAS) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The …
View article: Assessing and Responding to the Trauma of Child Maltreatment
Assessing and Responding to the Trauma of Child Maltreatment Open
Child maltreatment is a significant risk factor for severe psychiatric outcomes in childhood and contributes to problematic symptoms that direct parents, teachers, or other invested parties to seek psychiatric intervention. With ongoing wo…
View article: Response of US psychiatric programs to the COVID-19 pandemic and the impact on trainees
Response of US psychiatric programs to the COVID-19 pandemic and the impact on trainees Open
View article: Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide
Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide Open
Suicide accounts for >800,000 deaths annually worldwide; prevention is an urgent public health issue. Identification of risk factors remains challenging due to complexity and heterogeneity. The study of suicide deaths with increased extend…
View article: Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis
Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis Open
Proper growth of dendrites is critical to the formation of neuronal circuits, but the cellular machinery that directs the addition of membrane components to generate dendritic architecture remains obscure. Here, we demonstrate that post-Go…
View article: Suicide and Psychosis: Results From a Population-Based Cohort of Suicide Death (<i>N</i>= 4380)
Suicide and Psychosis: Results From a Population-Based Cohort of Suicide Death (<i>N</i>= 4380) Open
Approximately 5% of individuals with schizophrenia die from suicide. However, suicide in psychosis is still poorly characterized, partly due to a lack of adequate population-based clinical or genetic data on suicide death. The Utah Suicide…
View article: Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors Open
View article: Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach
Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach Open
View article: Response of US Psychiatric Programs to the COVID-19 Pandemic and the Impact on Trainees
Response of US Psychiatric Programs to the COVID-19 Pandemic and the Impact on Trainees Open
Background: Medical training program and hospital response to the COVID-19 pandemic has varied greatly and has impacted trainee well-being. Which factors have specifically affected trainee wellness, however, has not yet been examined in de…
View article: Rare protein‐coding variants implicate genes involved in risk of suicide death
Rare protein‐coding variants implicate genes involved in risk of suicide death Open
Identification of genetic factors leading to increased risk of suicide death is critical to combat rising suicide rates, however, only a fraction of the genetic variation influencing risk has been accounted for. To address this limitation,…
View article: Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder
Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder Open
View article: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder
Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder Open
Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences of 3,987 unrelated …
View article: Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors
Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors Open
Suicide is a leading cause of death worldwide and non-fatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both are known to have a substantial genetic etiology, which is…
View article: A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields
A Model for Migratory B Cell Oscillations from Receptor Down-Regulation Induced by External Chemokine Fields Open
A long-standing paradigm in B cell immunology is that effective somatic hypermutation and affinity maturation require cycling between the dark zone and light zone of the germinal center. The cyclic re-entry hypothesis was first proposed ba…
View article: Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents
Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents Open
Multiple genome-wide significant loci and genes were identified and polygenic score prediction of suicide death case-control status was demonstrated, adjusting for ancestry, in independent training and test sets. Additionally, the suicide …