Eric Wimmer
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View article: Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line <sup>19</sup>F NMR analyses and optimization algorithms
Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line <sup>19</sup>F NMR analyses and optimization algorithms Open
A continuous flow synthesis of FGIN-1-27 has been developed using enabling technologies such as real-time in-line benchtop 19 F NMR analysis and an optimization algorithm.
View article: Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor
Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor Open
Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C−H arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous self‐optimizing flow platform was used to efficiently optimiz…
View article: Comparing Gas–Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform
Comparing Gas–Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform Open
The hazardous nature of molecular oxygen can be mitigated with the use of flow reactors of small size, which in turn accelerate the gas-to-liquid mass transfer rate. In this contribution, we describe a reconfigurable automated flow platfor…
View article: Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis
Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis Open
Naturally occurring benzoxanthenones, which belong to the vast family of lignans, are promising biologically relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this manuscript, we d…
View article: An Autonomous Self-Optimizing Flow Reactor for the Synthesis of Natural Product Carpanone
An Autonomous Self-Optimizing Flow Reactor for the Synthesis of Natural Product Carpanone Open
A modular autonomous flow reactor combining monitoring technologies with a feedback algorithm is presented for the synthesis of the natural product carpanone. The autonomous self-optimizing system, controlled via MATLAB, was designed as a …
View article: Frontispiece: Zeolite‐Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal‐Doped Zeolite‐Catalyzed Steps
Frontispiece: Zeolite‐Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal‐Doped Zeolite‐Catalyzed Steps Open
Zeolite-Based Organic Synthesis (ZeoBOS) This new concept is described for the efficient access to structurally complex and functionalized molecules and illustrated with the total synthesis of acortatarin A, a unique antioxidant natural pr…