Explanipedia

Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis Open

Jennifer A. Simonovich, Sabrina L. Macias, Mingqi Zhou, Michael A. Portelli, I. C. Verma , et al. · 2025

Notch-activated basophils support intestinal CD4+ T cell fate and function during Trichuris muris infection Open

Lauren M. Webb, Lindsey Warner, Eric Y. Helm, Bridget Mooney, Pavithra Sundaravaradan , et al. · 2025

Nutrition impact on ILC3 maintenance and function centers on a cell-intrinsic CD71–iron axis Open

Lifeng Xiong, Eric Y. Helm, Joseph Dean, Na Sun, Felix R. Jimenez , et al. · 2023

Bcl11b regulates multipotency and effector programs in intestinal resident memory CD8+ T cells Open

Τόμας Ζελένκα, Eric Y. Helm, Valeriu B. Cismasiu, Shamima Islam, Leonardo Silvane , et al. · 2023

Tissue-resident memory CD8+ T cells (Trm) reside in non-lymphoid tissues and provide potent protection from re-infection. They are multipotent and have diverse functions, including effector roles during re-infection. Using a series of RNA-…

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase Open

Evelyn Bracho-Sanchez, Fernanda Regina Godoy Rocha, Sean K. Bedingfield, Brittany D. Partain, Sabrina L. Macias , et al. · 2023

Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells Open

Eric Y. Helm, Τόμας Ζελένκα, Valeriu B. Cismasiu, Shamima Islam, Leonardo Silvane , et al. · 2023

The networks of transcription factors (TFs) that control intestinal-resident memory CD8 + T (T RM ) cells, including multipotency and effector programs, are poorly understood. In this work, we investigated the role of the TF Bcl11b in T RM…

Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor Open

Eric Y. Helm, Liang Zhou · 2023

The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins. Altho…

The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8+ T cell differentiation and function Open

Joseph Dean, Eric Y. Helm, Zheng Fu, Lifeng Xiong, Na Sun , et al. · 2023

The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of CD4⁺ T cells; however, its cell-intrinsic role in CD8⁺ T cells remains elusive. Herein we show that Ahr acts as a promoter of resident …

Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice Open

Alexander J. Kwiatkowski, Eric Y. Helm, Joshua M. Stewart, Theodore T. Drashansky, Jonathan Cho , et al. · 2022

Antigen-specific therapies hold promise for treating autoimmune diseases such as multiple sclerosis while avoiding the deleterious side effects of systemic immune suppression due to delivering the disease-specific antigen as part of the tr…

Treatment with an Antigen-Specific Dual Microparticle System Reverses Advanced Multiple Sclerosis in Mice Open

Alexander J. Kwiatkowski, Eric Y. Helm, Joshua M. Stewart, Theodore T. Drashansky, Jonathan Cho , et al. · 2022

Antigen-specific therapies hold promise for treating autoimmune diseases such as multiple sclerosis while avoiding the deleterious side effects of systemic immune suppression. In this study, an antigen-specific dual-sized microparticle (dM…

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells Open

Myung‐Chul Kim, Nicholas Borcherding, Kawther Khalid Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma , et al. · 2021

Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation Open

Evelyn Bracho-Sanchez, Fernanda Regina Godoy Rocha, Sean K. Bedingfield, Brittany D. Partain, Maigan A. Brusko , et al. · 2021

Summary paragraph Chronic inflammation underlies the onset, progression and associated pain of numerous diseases.( 1 ) Current anti-inflammatory treatments administered systemically are associated with moderate-to-severe side effects, whil…

BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program Open

Theodore T. Drashansky, Eric Y. Helm, Nina B. Curkovic, Jaimee Cooper, Pingyan Cheng , et al. · 2021

The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation Open

Tim D. Holmes, Ram Vinay Pandey, Eric Y. Helm, Heinrich Schlums, Hongya Han , et al. · 2021

Epigenetic and functional analyses of human NK cells identify a role for Bcl11b in canonical and adaptive NK cell differentiation.

BCL11B Regulates Arterial Stiffness and Related Target Organ Damage Open

Jeff Arni C. Valisno, Joel May, Kuldeep Singh, Eric Y. Helm, Lisia Venegas , et al. · 2021

Rationale: BCL11B (B-cell leukemia 11b) is a transcription factor known as an essential regulator of T lymphocytes and neuronal development during embryogenesis. A genome-wide association study showed that a gene desert region downstream o…

Bcl11b prevents fatal autoimmunity by promoting T reg cell program and constraining innate lineages in T reg cells Open

Theodore T. Drashansky, Eric Y. Helm, Zhiguang Huo, Nina B. Curkovic, Preet Kumar , et al. · 2019

Lack of Bcl11b in T reg cells causes fatal autoimmunity and altered T reg cell program and identity.

Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation Open

Jonathan Cho, Zhiwei Xu, Upasana Parthasarathy, Theodore T. Drashansky, Eric Y. Helm , et al. · 2019

Reinterpreting recent thymic emigrant function: defective or adaptive? Open

Cody A. Cunningham, Eric Y. Helm, Pamela J. Fink · 2017

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