Explanipedia

A novel workflow for 3D imaging and spatial analysis of nerves in bone Open

Allison L Horenberg, Eric Z. Zeng, Yunke Ren, Tanishk Sinha, Emith Uyanwatte , et al. · 2025

Peripheral sensory and sympathetic nerves innervating bony tissues are of interest for their role in modulating bone function and responding to physiologic stimuli. However, due to their filamentous structure and small diameter, peripheral…

3D imaging reveals changes in the neurovascular architecture of the murine calvarium with aging Open

Allison L. Horenberg, Yunke Ren, Eric Z. Zeng, Alexandra N. Rindone, Arvind P. Pathak , et al. · 2025

Calvarial nerves, along with vasculature, influence skull formation during development and following injury, but it remains unclear how calvarial nerves are spatially distributed during postnatal growth and aging. Studying the spatial dist…

A Novel Workflow for 3d Imaging and Spatial Analysis of Nerves in Bone Open

Allison L Horenberg, Eric Z. Zeng, Yunke Ren, Tanishk Sinha, Emith Uyanwatte , et al. · 2025

Surface Engineering of Auxetic Scaffolds for Neural and Vascular Differentiation from Human Pluripotent Stem Cells Open

Xingchi Chen, Chang Liu, Matthew Wadsworth, Eric Z. Zeng, Tristan P. Driscoll , et al. · 2022

Auxetic materials are the materials that can display negative Poisson's ratio that describes the degree to which a material contracts (or expands) transversally when axially strained. Human stem cells sense the mechanical properties of the…

Bioreactor expansion reconfigures metabolism and extracellular vesicle biogenesis of human adipose-derived stem cells in vitro Open

Richard Jeske, Xingchi Chen, Shaoyang Ma, Eric Z. Zeng, Tristan P. Driscoll , et al. · 2022

Bioengineering Human Pluripotent Stem Cell-Derived Retinal Organoids and Optic Vesicle-Containing Brain Organoids for Ocular Diseases Open

Peggy Arthur, Laureana Muok, Aakash Nathani, Eric Z. Zeng, Li Sun , et al. · 2022

Retinal organoids are three-dimensional (3D) structures derived from human pluripotent stem cells (hPSCs) that mimic the retina’s spatial and temporal differentiation, making them useful as in vitro retinal development models. Retinal orga…

Exosomal MicroRNAs as Novel Cell-Free Therapeutics in Tissue Engineering and Regenerative Medicine Open

Eric Z. Zeng, Isabelle Chen, Xingchi Chen, Xuegang Yuan · 2022

Extracellular vesicles (EVs) are membrane-bound vesicles (50–1000 nm) that can be secreted by all cell types. Microvesicles and exosomes are the major subsets of EVs that exhibit the cell–cell communications and pathological functions of h…

Downstream bioprocessing of human pluripotent stem cell‐derived therapeutics Open

Sébastien Sart, Chang Liu, Eric Z. Zeng, Chunhui Xu, Yan Li · 2021

With the advancement in lineage‐specific differentiation from human pluripotent stem cells (hPSCs), downstream cell separation has now become a critical step to produce hPSC‐derived products. Since differentiation procedures usually result…

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