Erica E. Vine
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View article: Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract
Dendritic cells and HIV transmission: roles and subsets of antigen-presenting cells in the human anogenital tract Open
Dendritic cells (DCs) are potent antigen-presenting cells and play a key role in facilitating the sexual transmission of HIV, functioning as a delivery system responsible for trafficking the virus from exposed barrier sites to their key ta…
View article: Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV
Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV Open
AXL + Siglec-6 + dendritic cells (ASDC) are novel myeloid DCs which can be subdivided into CD11c + and CD123 + expressing subsets. We showed for the first time that these two ASDC subsets are present in inflamed human anogenital tissues wh…
View article: Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines
Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines Open
Next-generation vaccines may be delivered via the skin and mucosa. The stratified squamous epithelium (SSE) represents the outermost layer of the skin (epidermis) and type II mucosa (epithelium). Langerhans cells (LCs) have been considered…
View article: An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission
An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission Open
The initial immune response to HIV determines transmission. However, due to technical limitations we still do not have a comparative map of early mucosal transmission events. By combining RNAscope, cyclic immunofluorescence, and image anal…
View article: SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity Open
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune components in longitudinal blood and respiratory samples from hospi…
View article: An <i>in situ</i> quantitative map of initial human colorectal HIV transmission
An <i>in situ</i> quantitative map of initial human colorectal HIV transmission Open
The initial immune response to HIV is critical in determining transmission. However, due to technical limitations we still do not have a comparative map of early mucosal transmission events. We combined RNAscope, cyclic-immunofluorescence …
View article: HIV transmitting mononuclear phagocytes; integrating the old and new
HIV transmitting mononuclear phagocytes; integrating the old and new Open
In tissue, mononuclear phagocytes (MNP) are comprised of Langerhans cells, dendritic cells, macrophages and monocyte-derived cells. They are the first immune cells to encounter HIV during transmission and transmit the virus to CD4 T cells …
View article: An <i>in situ</i> Quantitative Map of Initial Human Colorectal HIV Transmission
An <i>in situ</i> Quantitative Map of Initial Human Colorectal HIV Transmission Open
View article: Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue
Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue Open
The human intestine contains numerous mononuclear phagocytes (MNP), including subsets of conventional dendritic cells (cDC), macrophages (Mf) and monocytes, each playing their own unique role within the intestinal immune system and homeost…
View article: Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells Open