Erick Duan
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View article: Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan
Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan Open
Introduction Dysregulated immunity may account for an increased risk of infection and other adverse outcomes among frail hospitalised persons. The primary objective of this study is to examine whether baseline frailty is associated with th…
View article: Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation Open
Importance The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown. Objective To evaluat…
View article: Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol
Cuff leak test and airway obstruction in mechanically ventilated ICU patients (COSMIC): a pilot feasibility randomized controlled trial protocol Open
Introduction The cuff leak test (CLT) is hypothesised to help optimise extubation by assessing for laryngeal oedema which, if unrecognised and untreated, could lead to post-extubation stridor, post-extubation airway obstruction, and reintu…
View article: Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial Open
Background Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease antimicrobial resistance. We compared gut microbiome disruption and ARG carriag…
View article: Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial
Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial Open
Background Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early in-bed cycle ergometry, may improve patients’ shor…
View article: Early in-bed cycle ergometry with critically ill, mechanically ventilated patients - Statistical Analysis Plan for CYCLE (Critical care cycling to improve lower extremity strength), an international, multi-centre, randomized clinical trial (Preprint)
Early in-bed cycle ergometry with critically ill, mechanically ventilated patients - Statistical Analysis Plan for CYCLE (Critical care cycling to improve lower extremity strength), an international, multi-centre, randomized clinical trial (Preprint) Open
BACKGROUND Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early-in bed cycle ergometry, may improve patients’ sho…
View article: Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care Open
Importance Blood collection for laboratory testing in intensive care unit (ICU) patients is a modifiable contributor to anemia and red blood cell (RBC) transfusion. Most blood withdrawn is not required for analysis and is discarded. Object…
View article: <i>C</i> ritical Care C <i>yc</i> ling to Improve <i>L</i> ower <i>E</i> xtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients
<i>C</i> ritical Care C <i>yc</i> ling to Improve <i>L</i> ower <i>E</i> xtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients Open
Introduction In-bed leg cycling with critically ill patients is a promising intervention aimed at minimising immobility, thus improving physical function following intensive care unit (ICU) discharge. We previously completed a pilot random…
View article: Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach
Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach Open
OBJECTIVES: Proliferation of COVID-19 research underscored the need for improved awareness among investigators, research staff and bedside clinicians of the operational details of clinical studies. The objective was to describe the genesis…
View article: Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics
Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics Open
OBJECTIVES: Clinical research in Canada is conducted primarily in “academic” hospitals, whereas most clinical care is provided in “community” hospitals. The objective of this nested observational study was to compare patient characteristic…
View article: Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial
Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial Open
ClinicalTrials. gov, no. NCT04330690.
View article: Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study
Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study Open
PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial): NCT02462590.
View article: Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure
Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure Open
ClinicalTrials.gov Identifier: NCT04350723.
View article: Motivating factors, barriers and facilitators of participation in COVID-19 clinical research: A cross-sectional survey of Canadian community intensive care units
Motivating factors, barriers and facilitators of participation in COVID-19 clinical research: A cross-sectional survey of Canadian community intensive care units Open
Only a small proportion of COVID-19 patients in Canada have been recruited into clinical research studies. One reason is that few community intensive care units (ICUs) in Canada participate in research. The objective of this study was to e…
View article: Research interrupted: Applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic
Research interrupted: Applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic Open
Rationale: The COVID-19 pandemic disrupted non-COVID critical care trials globally as intensive care units (ICUs) prioritized patient care and COVID-specific research. The international randomized controlled trial CYCLE (Critical Care Cycl…
View article: Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards
Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards Open
PROSPERO Identifier: CRD42021245239.
View article: Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients
Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients Open
ClinicalTrials.gov Identifier: NCT02462590.
View article: Scale-up and Sustainability of a Personalized End-of-Life Care Intervention: A Longitudinal Mixed-Methods Study
Scale-up and Sustainability of a Personalized End-of-Life Care Intervention: A Longitudinal Mixed-Methods Study Open
Background: Scaling-up and sustaining healthcare interventions can be challenging. Our objective was to describe how the 3 Wishes Project (3WP), a personalized end-of-life intervention, was scaled-up and sustained in an intensive care unit…
View article: Initiating and integrating a personalized end of life care project in a community hospital intensive care unit: a mixed-method study of clinician and key stakeholder perspectives
Initiating and integrating a personalized end of life care project in a community hospital intensive care unit: a mixed-method study of clinician and key stakeholder perspectives Open
Rationale The end of life (EOL) experience in the intensive care unit (ICU) can be psychologically distressing. The 3 Wishes Project (3WP) personalizes the EOL experience by carrying out wishes for dying patients and their families. While …
View article: Participation of more community hospitals in randomized trials of treatments for COVID-19 is needed
Participation of more community hospitals in randomized trials of treatments for COVID-19 is needed Open
In their CMAJ commentary, Cheng and colleagues highlight the importance of evaluating potential COVID-19 therapies systematically within randomized controlled trials (RCTs).[1][1] In addition to cost, another limiting factor for clinical t…
View article: Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care
Fostering humanism: a mixed methods evaluation of the Footprints Project in critical care Open
Objectives The objectives of this mixed-methods study were to assess the uptake, sustainability and influence of the Footprints Project. Setting Twenty-two-bed university-affiliated ICU in Hamilton, Canada. Participants ICU patients admitt…
View article: Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT
Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT Open
Introduction Ventilator-associated pneumonia (VAP) is the most common healthcare-associated infection in critically ill patients. Prior studies suggest that probiotics may reduce VAP and other infections in critically ill patients; however…
View article: Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study
Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study Open
Introduction Diarrhoea is a frequent concern in the intensive care unit (ICU) and is associated with prolonged mechanical ventilation, increased length of ICU stay, skin breakdown and renal dysfunction. However, its prevalence, aetiology a…